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NCF2 neutrophil cytosolic factor 2 [ Bos mutus (wild yak) ]

Gene ID: 102269539, updated on 10-Mar-2024

Summary

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Gene symbol
NCF2
Gene description
neutrophil cytosolic factor 2
Locus tag
M91_14905
See related
Ensembl:ENSBMUG00000021265
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos mutus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
16
Annotation release Status Assembly Chr Location
101 current BosGru_v2.0 (GCF_000298355.1) Unplaced Scaffold NW_005393436.1 (618317..665999, complement)

NW_005393436.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106700723 Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene SMG7 nonsense mediated mRNA decay factor Neighboring gene actin related protein 2/3 complex subunit 5 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene ral guanine nucleotide dissociation stimulator like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_005393436.1 Unplaced Scaffold Reference BosGru_v2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in respiratory burst IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neutrophil cytosol factor 2
Names
Neutrophil cytosol factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bos mutus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BosGru_v2.0 Primary Assembly

Genomic

  1. NW_005393436.1 Reference BosGru_v2.0 Primary Assembly

    Range
    618317..665999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014477387.1 → XP_014332873.1  neutrophil cytosol factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A6B0RCD0
    Conserved Domains (7) summary
    cd06406
    Location:351 → 430
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244 → 297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:462 → 513
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    sd00006
    Location:37 → 65
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:71 → 98
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:71 → 150
    TPR_11; TPR repeat
    pfam13424
    Location:38 → 102
    TPR_12; Tetratricopeptide repeat

  2. XM_005893086.2 → XP_005893148.1  neutrophil cytosol factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A6B0RCD0
    Related
    ENSBMUP00000028428.1, ENSBMUT00000032761.1
    Conserved Domains (7) summary
    cd06406
    Location:350 → 429
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244 → 297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:461 → 512
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    sd00006
    Location:37 → 65
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:71 → 98
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:71 → 150
    TPR_11; TPR repeat
    pfam13424
    Location:38 → 102
    TPR_12; Tetratricopeptide repeat

  3. XM_005893085.2 → XP_005893147.1  neutrophil cytosol factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A6B0RCD0
    Related
    ENSBMUP00000028422.1, ENSBMUT00000032755.1
    Conserved Domains (7) summary
    cd06406
    Location:351 → 430
    PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
    cd11871
    Location:244 → 297
    SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    cd12046
    Location:462 → 513
    SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
    sd00006
    Location:37 → 65
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:71 → 98
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:71 → 150
    TPR_11; TPR repeat
    pfam13424
    Location:38 → 102
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein
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