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ptpro protein tyrosine phosphatase receptor type O [ Xiphophorus maculatus (southern platyfish) ]

Gene ID: 102234137, updated on 10-Mar-2024

Summary

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Gene symbol
ptpro
Gene description
protein tyrosine phosphatase receptor type O
See related
Ensembl:ENSXMAG00000009306
Gene type
protein coding
RefSeq status
MODEL
Organism
Xiphophorus maculatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; Xiphophorus
Orthologs
human zebrafish all
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Genomic context

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See ptpro in Genome Data Viewer
Location:
chromosome: 17
Exon count:
27
Annotation release Status Assembly Chr Location
102 current X_maculatus-5.0-male (GCF_002775205.1) 17 NC_036459.1 (273159..293571)
101 previous assembly Xiphophorus_maculatus-4.4.2 (GCF_000241075.1) Unplaced Scaffold NW_005372654.1 (40191..159445, complement)

Chromosome 17 - NC_036459.1Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 2 Neighboring gene CASP2 and RIPK1 domain containing adaptor with death domain Neighboring gene DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) Neighboring gene transmembrane protein 243, mitochondrial b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in podocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of glomerular filtration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase O

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xiphophorus maculatus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference X_maculatus-5.0-male Primary Assembly

Genomic

  1. NC_036459.1 Reference X_maculatus-5.0-male Primary Assembly

    Range
    273159..293571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023350316.1 → XP_023206084.1  receptor-type tyrosine-protein phosphatase O isoform X1

    UniProtKB/TrEMBL
    M4A4E8
    Related
    ENSXMAP00000009342.2, ENSXMAT00000009356.2
    Conserved Domains (3) summary
    cd00047
    Location:969 → 1198
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437 → 527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:730 → 802
    fn3; Fibronectin type III domain

  2. XM_023350317.1 → XP_023206085.1  receptor-type tyrosine-protein phosphatase O isoform X2

    UniProtKB/TrEMBL
    M4A4E8
    Conserved Domains (3) summary
    cd00047
    Location:941 → 1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437 → 527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:730 → 802
    fn3; Fibronectin type III domain

  3. XM_023350319.1 → XP_023206087.1  receptor-type tyrosine-protein phosphatase O isoform X3

    UniProtKB/TrEMBL
    M4A4E8
    Conserved Domains (3) summary
    cd00047
    Location:929 → 1158
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437 → 527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:730 → 802
    fn3; Fibronectin type III domain
Nucleotide Protein Strain
Heading Accession and Version

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