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PLCG2 phospholipase C gamma 2 [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102117471, updated on 1-Aug-2024

Summary

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Gene symbol
PLCG2
Gene description
phospholipase C gamma 2
See related
Ensembl:ENSMFAG00000042565
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 20 NC_088394.1 (77612429..77851649)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 20 NC_052274.1 (68511689..68702799)

Chromosome 20 - NC_088394.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC135968728 Neighboring gene c-Maf inducing protein Neighboring gene uncharacterized LOC123570498 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene hydroxysteroid 17-beta dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
phospholipase C, gamma 2 (phosphatidylinositol-specific)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088394.1 Reference T2T-MFA8v1.0

    Range
    77612429..77851649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_065536926.1 → XP_065392998.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    UniProtKB/TrEMBL
    A0A2K5W153, A0A7N9I9Q2

  2. XM_005592638.4 → XP_005592695.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    See identical proteins and their annotated locations for XP_005592695.1

    UniProtKB/TrEMBL
    A0A2K5W153, A0A7N9I9Q2
    Related
    ENSMFAP00000030810.1
    Conserved Domains (10) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311 → 458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641 → 744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840 → 910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22 → 140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:926 → 1031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475 → 510
    PH-like; Pleckstrin homology-like domain

  3. XM_045382340.2 → XP_045238275.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    UniProtKB/TrEMBL
    A0A2K5W153, A0A7N9I9Q2
    Conserved Domains (10) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311 → 458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641 → 744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840 → 910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22 → 140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:926 → 1031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475 → 510
    PH-like; Pleckstrin homology-like domain

  4. XM_015443020.3 → XP_015298506.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

    UniProtKB/TrEMBL
    A0A7N9I9Q2
    Conserved Domains (8) summary
    cd00275
    Location:994 → 1120
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:244 → 391
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:574 → 677
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:460 → 560
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:706 → 760
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:773 → 843
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cl14615
    Location:859 → 964
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:1 → 73
    PH-like; Pleckstrin homology-like domain

  5. XM_065536927.1 → XP_065392999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

    UniProtKB/TrEMBL
    A0A7N9I9Q2

  6. XM_015443021.3 → XP_015298507.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

    UniProtKB/TrEMBL
    A0A7N9I9Q2
    Conserved Domains (8) summary
    cd00275
    Location:994 → 1120
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:244 → 391
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:574 → 677
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:460 → 560
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:706 → 760
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:773 → 843
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cl14615
    Location:859 → 964
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:1 → 73
    PH-like; Pleckstrin homology-like domain

  7. XM_065536928.1 → XP_065393000.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A7N9CCZ4
Nucleotide Protein
Heading Accession and Version

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