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Mthfr methylenetetrahydrofolate reductase [ Ictidomys tridecemlineatus (thirteen-lined ground squirrel) ]

Gene ID: 101956899, updated on 8-Mar-2024

Summary

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Gene symbol
Mthfr
Gene description
methylenetetrahydrofolate reductase
See related
EnsemblRapid:ENSSTOG00015015165
Gene type
protein coding
RefSeq status
MODEL
Organism
Ictidomys tridecemlineatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae; Xerinae; Marmotini; Ictidomys
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
103 current HiC_Itri_2 (GCF_016881025.1) Unplaced Scaffold NW_024405058.1 (34798656..34813131, complement)
102 previous assembly SpeTri2.0 (GCF_000236235.1) Unplaced Scaffold NW_004936474.1 (623438..637849, complement)

NW_024405058.1Genomic Context describing neighboring genes Neighboring gene angiotensin II receptor associated protein Neighboring gene chromosome unknown C1orf167 homolog Neighboring gene chloride voltage-gated channel 6 Neighboring gene natriuretic peptide A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methylenetetrahydrofolate reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ictidomys tridecemlineatus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HiC_Itri_2 Primary Assembly

Genomic

  1. NW_024405058.1 Reference HiC_Itri_2 Primary Assembly

    Range
    34798656..34813131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021733491.2 → XP_021589166.1  methylenetetrahydrofolate reductase isoform X4

    UniProtKB/TrEMBL
    I3MA17
    Conserved Domains (1) summary
    cl00246
    Location:57 → 623
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  2. XM_021733482.2 → XP_021589157.1  methylenetetrahydrofolate reductase isoform X4

    UniProtKB/TrEMBL
    I3MA17
    Conserved Domains (1) summary
    cl00246
    Location:57 → 623
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  3. XM_040287928.1 → XP_040143862.1  methylenetetrahydrofolate reductase isoform X1

    Conserved Domains (1) summary
    cl00246
    Location:98 → 664
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  4. XM_040287929.1 → XP_040143863.1  methylenetetrahydrofolate reductase isoform X2

    Conserved Domains (1) summary
    cl00246
    Location:98 → 657
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  5. XM_013364404.3 → XP_013219858.1  methylenetetrahydrofolate reductase isoform X3

    Related
    ENSSTOP00015018552.1, ENSSTOT00015020342.1
    Conserved Domains (1) summary
    cl00246
    Location:77 → 643
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  6. XM_040287930.1 → XP_040143864.1  methylenetetrahydrofolate reductase isoform X5

    Conserved Domains (1) summary
    cl00246
    Location:98 → 568
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
Nucleotide Protein
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