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PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Chrysemys picta bellii (western painted turtle) ]

Gene ID: 101942651, updated on 1-Aug-2024

Summary

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Gene symbol
PAICS
Gene description
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Gene type
protein coding
RefSeq status
MODEL
Organism
Chrysemys picta bellii (sub-species: bellii)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; Testudinoidea; Emydidae; Chrysemys
Orthologs
human all
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Genomic context

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Location:
chromosome: 5
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_05 current ASM1138683v2 (GCF_011386835.1) 5 NC_088795.1 (90162762..90223570, complement)
102 previous assembly Chrysemys_picta_bellii-3.0.3 (GCF_000241765.3) 4 NC_024221.1 (38209437..38270072)

Chromosome 5 - NC_088795.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 9B (putative) Neighboring gene uncharacterized LOC135983713 Neighboring gene LON peptidase N-terminal domain and ring finger 1 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene capping protein inhibiting regulator of actin dynamics

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Names
phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_011386835.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1138683v2

Genomic

  1. NC_088795.1 Reference ASM1138683v2

    Range
    90162762..90223570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042841914.2 → XP_042697848.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X4

    UniProtKB/TrEMBL
    A0AAJ7XYE1, A0AAJ7XYE8
    Conserved Domains (3) summary
    cd01416
    Location:606 → 857
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:867 → 1020
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:396 → 460
    GT1; myb-like, SANT family

  2. XM_065596868.1 → XP_065452940.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X9

    UniProtKB/TrEMBL
    A0AAJ7XYE8

  3. XM_024101677.3 → XP_023957445.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X3

    UniProtKB/TrEMBL
    A0AAJ7QR64, A0AAJ7XYE8
    Conserved Domains (3) summary
    cd01416
    Location:636 → 887
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:897 → 1050
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    pfam13837
    Location:425 → 511
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  4. XM_042841916.2 → XP_042697850.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X8

    UniProtKB/TrEMBL
    A0AAJ7XYE8, A0AAJ7XYF3
    Conserved Domains (3) summary
    cd01416
    Location:534 → 785
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:795 → 948
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    cl23759
    Location:7 → 74
    GT1; myb-like, SANT family

  5. XM_024101674.3 → XP_023957442.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

    UniProtKB/TrEMBL
    A0AAJ7QR61, A0AAJ7XYE8
    Conserved Domains (3) summary
    cd01416
    Location:668 → 919
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:929 → 1082
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
    pfam13837
    Location:457 → 543
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  6. XM_065596867.1 → XP_065452939.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X7

    UniProtKB/TrEMBL
    A0AAJ7XYE8

  7. XM_065596863.1 → XP_065452935.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1

    UniProtKB/TrEMBL
    A0AAJ7XYE8

  8. XM_065596869.1 → XP_065452941.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X10

    UniProtKB/TrEMBL
    A0AAJ7XYE8

  9. XM_065596870.1 → XP_065452942.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X11

  10. XM_065596865.1 → XP_065452937.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X5

    UniProtKB/TrEMBL
    A0AAJ7XYE8

  11. XM_065596866.1 → XP_065452938.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X6

    UniProtKB/TrEMBL
    A0AAJ7XYE8

  12. XM_005299139.5 → XP_005299196.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X13

    UniProtKB/TrEMBL
    A0AAJ7XYF2
    Conserved Domains (2) summary
    cd01416
    Location:8 → 259
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:269 → 422
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  13. XM_042841918.2 → XP_042697852.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X12

    UniProtKB/TrEMBL
    A0AAJ7XYF0
    Conserved Domains (2) summary
    cd01416
    Location:28 → 279
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:289 → 442
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
Nucleotide Protein
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