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Pappa pappalysin 1 [ Heterocephalus glaber (naked mole-rat) ]

Gene ID: 101725271, updated on 8-Mar-2024

Summary

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Gene symbol
Pappa
Gene description
pappalysin 1
Locus tag
GW7_01800
See related
Ensembl:ENSHGLG00000019341
Gene type
protein coding
RefSeq status
MODEL
Organism
Heterocephalus glaber
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624760.1 (18842353..19078657, complement)

NW_004624760.1Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene tripartite motif containing 32 Neighboring gene uncharacterized LOC101718323 Neighboring gene uncharacterized LOC110350194 Neighboring gene uncharacterized LOC110350121

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004624760 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: pappalysin-1
Names
Pappalysin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HetGla_female_1.0 Primary Assembly

Genomic

  1. NW_004624760.1 Reference HetGla_female_1.0 Primary Assembly

    Range
    18842353..19078657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021262175.1 → XP_021117834.1  LOW QUALITY PROTEIN: pappalysin-1

    UniProtKB/TrEMBL
    G5B3H2
    Related
    ENSHGLP00000027195.1, ENSHGLT00000027436.1
    Conserved Domains (6) summary
    cd00033
    Location:1341 → 1416
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00004
    Location:1542 → 1578
    NL; Domain found in Notch and Lin-12
    TIGR02232
    Location:939 → 978
    myxo_disulf_rpt; Myxococcus cysteine-rich repeat
    smart00560
    Location:111 → 261
    LamGL; LamG-like jellyroll fold domain
    cd04275
    Location:419 → 655
    ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
    pfam00084
    Location:1410 → 1466
    Sushi; Sushi repeat (SCR repeat)
Nucleotide Protein
Heading Accession and Version

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