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ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 [ Mustela putorius furo (domestic ferret) ]

Gene ID: 101674677, updated on 8-Mar-2024

Summary

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Gene symbol
ARHGEF18
Gene description
Rho/Rac guanine nucleotide exchange factor 18
See related
Ensembl:ENSMPUG00000008399
Gene type
protein coding
RefSeq status
MODEL
Organism
Mustela putorius furo (sub-species: furo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Mustela
Orthologs
human mouse all
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Genomic context

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See ARHGEF18 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
35
Annotation release Status Assembly Chr Location
102 current ASM1176430v1.1 (GCF_011764305.1) Unplaced Scaffold NW_025421280.1 (35474047..35555088)
101 previous assembly MusPutFur1.0 (GCF_000215625.1) Unplaced Scaffold NW_004569306.1 (3853389..3934540, complement)

NW_025421280.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 558 Neighboring gene insulin receptor Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequencing, annotation, and characterization of the influenza ferret infectome. León AJ, et al. J Virol, 2013 Feb. PMID 23236062, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 18

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mustela putorius furo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1176430v1.1 Primary Assembly

Genomic

  1. NW_025421280.1 Reference ASM1176430v1.1 Primary Assembly

    Range
    35474047..35555088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045084559.1 → XP_044940494.1  rho guanine nucleotide exchange factor 18 isoform X2

    UniProtKB/TrEMBL
    A0A8U0V6F2
    Conserved Domains (4) summary
    cd00160
    Location:448 → 642
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:682 → 800
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1010 → 1143
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:1083 → 1235
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  2. XM_013045268.2 → XP_012900722.2  rho guanine nucleotide exchange factor 18 isoform X2

    UniProtKB/TrEMBL
    A0A8U0V6F2
    Conserved Domains (4) summary
    cd00160
    Location:448 → 642
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:682 → 800
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1010 → 1143
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:1083 → 1235
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  3. XM_013045269.2 → XP_012900723.2  rho guanine nucleotide exchange factor 18 isoform X3

    UniProtKB/TrEMBL
    A0A8U0NIG9
    Conserved Domains (4) summary
    cd00160
    Location:440 → 634
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:674 → 792
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1002 → 1135
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:1075 → 1227
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  4. XM_045084563.1 → XP_044940498.1  rho guanine nucleotide exchange factor 18 isoform X2

    UniProtKB/TrEMBL
    A0A8U0V6F2
    Conserved Domains (4) summary
    cd00160
    Location:448 → 642
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:682 → 800
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1010 → 1143
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:1083 → 1235
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  5. XM_045084554.1 → XP_044940489.1  rho guanine nucleotide exchange factor 18 isoform X1

    UniProtKB/TrEMBL
    A0A8U0V576
    Conserved Domains (4) summary
    cd00160
    Location:451 → 645
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:685 → 803
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1013 → 1146
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:1086 → 1238
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  6. XM_045084581.1 → XP_044940516.1  rho guanine nucleotide exchange factor 18 isoform X5

    UniProtKB/TrEMBL
    A0A8U0SEG5
    Conserved Domains (2) summary
    cd00160
    Location:451 → 645
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:685 → 803
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain

  7. XM_045084571.1 → XP_044940506.1  rho guanine nucleotide exchange factor 18 isoform X4

    UniProtKB/TrEMBL
    A0A8U0SCS7, M3YAI0
    Conserved Domains (4) summary
    cd00160
    Location:301 → 495
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:535 → 653
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:863 → 996
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:936 → 1088
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  8. XM_045084587.1 → XP_044940522.1  rho guanine nucleotide exchange factor 18 isoform X6

    UniProtKB/TrEMBL
    A0A8U0T951, M3YAI0
    Conserved Domains (4) summary
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:336 → 454
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:664 → 797
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:737 → 889
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  9. XM_013045270.2 → XP_012900724.2  rho guanine nucleotide exchange factor 18 isoform X6

    UniProtKB/TrEMBL
    A0A8U0T951, M3YAI0
    Conserved Domains (4) summary
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:336 → 454
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:664 → 797
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:737 → 889
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
Nucleotide Protein
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