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CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [ Ochotona princeps (American pika) ]

Gene ID: 101536661, updated on 18-Sep-2024

Summary

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Gene symbol
CAD
Gene description
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Gene type
protein coding
RefSeq status
MODEL
Organism
Ochotona princeps
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Ochotonidae; Ochotona
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2023_07 current mOchPri1.hap1 (GCF_030435755.1) 8 NC_080839.1 (63550241..63571622, complement)
102 previous assembly OchPri4.0 (GCF_014633375.1) 2 NC_050537.1 (20551658..20572815)

Chromosome 8 - NC_080839.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene solute carrier family 30 member 3 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene solute carrier family 5 member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aspartate carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of carbamoyl-phosphate synthase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CAD protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030435755.1-RS_2023_07

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOchPri1.hap1

Genomic

  1. NC_080839.1 Reference mOchPri1.hap1

    Range
    63550241..63571622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_058668150.1 → XP_058524133.1  CAD protein isoform X1

  2. XM_004582671.3 → XP_004582728.1  CAD protein isoform X2

    Conserved Domains (14) summary
    cd01744
    Location:178 → 354
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    PRK09060
    Location:1429 → 1810
    PRK09060; dihydroorotase; Validated
    COG0505
    Location:1 → 359
    CarA; Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism, Nucleotide transport and metabolism]
    PRK00856
    Location:1920 → 2224
    pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
    cd01316
    Location:1460 → 1806
    CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
    cd01423
    Location:1313 → 1438
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01369
    Location:391 → 1440
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00185
    Location:2072 → 2221
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    pfam00988
    Location:2 → 138
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02729
    Location:1925 → 2065
    OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
    pfam02786
    Location:514 → 716
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    pfam02787
    Location:801 → 921
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain
    pfam10573
    Location:1831 → 1884
    UPF0561; uncharacterized protein family UPF0561
    cl17255
    Location:1048 → 1248
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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