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PDE8A phosphodiesterase 8A [ Odobenus rosmarus divergens (Pacific walrus) ]

Gene ID: 101367637, updated on 8-Mar-2024

Summary

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Gene symbol
PDE8A
Gene description
phosphodiesterase 8A
Gene type
protein coding
RefSeq status
MODEL
Organism
Odobenus rosmarus divergens (sub-species: divergens)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae; Odobenus
Orthologs
human mouse all
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Genomic context

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See PDE8A in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
101 current Oros_1.0 (GCF_000321225.1) Unplaced Scaffold NW_004450348.1 (587437..735760, complement)

NW_004450348.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene ribosomal protein S17 Neighboring gene solute carrier family 28 member 1 Neighboring gene alpha kinase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004450348.1 Unplaced Scaffold Reference Oros_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Odobenus rosmarus divergens Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Oros_1.0 Primary Assembly

Genomic

  1. NW_004450348.1 Reference Oros_1.0 Primary Assembly

    Range
    587437..735760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004398265.1 → XP_004398322.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    UniProtKB/TrEMBL
    A0A2U3VSX9
    Conserved Domains (4) summary
    COG0745
    Location:88 → 175
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:515 → 767
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 24
    PDE8; PDE8 phosphodiesterase
    cl19078
    Location:89 → 175
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

  2. XM_004398264.1 → XP_004398321.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    UniProtKB/TrEMBL
    A0A2U3VSP7
    Conserved Domains (6) summary
    COG0745
    Location:88 → 175
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    cd00130
    Location:236 → 330
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:561 → 813
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 24
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:232 → 330
    PAS_9; PAS domain
    cl19078
    Location:89 → 175
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
Nucleotide Protein
Heading Accession and Version

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