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MTHFR methylenetetrahydrofolate reductase [ Orcinus orca (killer whale) ]

Gene ID: 101287316, updated on 8-Mar-2024

Summary

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Gene symbol
MTHFR
Gene description
methylenetetrahydrofolate reductase
See related
EnsemblRapid:ENSOORG00010019461
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 1 NC_064559.1 (203665986..203679302)

Chromosome 1 - NC_064559.1Genomic Context describing neighboring genes Neighboring gene natriuretic peptide A Neighboring gene chloride voltage-gated channel 6 Neighboring gene chromosome 1 C1orf167 homolog Neighboring gene angiotensin II receptor associated protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064559.1 Chromosome 1 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methylenetetrahydrofolate reductase (NADPH)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064559.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    203665986..203679302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_049707292.1 → XP_049563249.1  methylenetetrahydrofolate reductase (NADPH) isoform X2

    Related
    ENSOORP00010025786.1, ENSOORT00010029225.1

  2. XM_049707285.1 → XP_049563242.1  methylenetetrahydrofolate reductase (NADPH) isoform X2

  3. XM_049707287.1 → XP_049563244.1  methylenetetrahydrofolate reductase (NADPH) isoform X2

  4. XM_049707286.1 → XP_049563243.1  methylenetetrahydrofolate reductase (NADPH) isoform X2

  5. XM_033432963.2 → XP_033288854.1  methylenetetrahydrofolate reductase (NADPH) isoform X3

    Conserved Domains (1) summary
    cl00246
    Location:100 → 550
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

  6. XM_004272399.4 → XP_004272447.1  methylenetetrahydrofolate reductase (NADPH) isoform X1

    Related
    ENSOORP00010025780.1, ENSOORT00010029219.1
    Conserved Domains (1) summary
    cl00246
    Location:100 → 666
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
Nucleotide Protein
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