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sos2 son of sevenless homolog 2 (Drosophila) [ Oryzias latipes (Japanese medaka) ]

Gene ID: 101168334, updated on 8-Mar-2024

Summary

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Gene symbol
sos2
Gene description
son of sevenless homolog 2 (Drosophila)
See related
EnsemblRapid:ENSORLG00000009137
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 22
Exon count:
22
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 22 NC_019880.2 (1362230..1390731)
102 previous assembly ASM31367v1 (GCF_000313675.1) 22 NC_019880.1 (676057..699140)

Chromosome 22 - NC_019880.2Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase-like 1 (CDC2-related kinase) Neighboring gene distal membrane arm assembly component 2 like Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized LOC105356878 Neighboring gene cyclin-dependent kinase inhibitor 3 Neighboring gene cornichon family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2
Names
SOS Ras/Rho guanine nucleotide exchange factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019880.2 Reference ASM223467v1 Primary Assembly

    Range
    1362230..1390731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023951616.1 → XP_023807384.1  son of sevenless homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A3P9GXG5
    Related
    ENSORLP00000079691.1, ENSORLT00000084197.1
    Conserved Domains (5) summary
    smart00229
    Location:595 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:777 → 1016
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:437 → 543
    PH-like; Pleckstrin homology-like domain
    cl23830
    Location:57 → 168
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_023951617.1 → XP_023807385.1  son of sevenless homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A3P9GXG5, H2LZ87
    Related
    ENSORLP00000011459.2, ENSORLT00000011460.3
    Conserved Domains (5) summary
    smart00229
    Location:595 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:777 → 1016
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:437 → 543
    PH-like; Pleckstrin homology-like domain
    cl23830
    Location:57 → 168
    Histone; Core histone H2A/H2B/H3/H4
Nucleotide Protein
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