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EPS8L2 EPS8 signaling adaptor L2 [ Ovis aries (sheep) ]

Gene ID: 101102603, updated on 6-Jun-2024

Summary

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Gene symbol
EPS8L2
Gene description
EPS8 signaling adaptor L2
See related
EnsemblRapid:ENSOARG00020012276
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 21 NC_056074.1 (46997109..47015406, complement)

Chromosome 21 - NC_056074.1Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene transaldolase 1 Neighboring gene uncharacterized LOC121817485 Neighboring gene transmembrane protein 80 Neighboring gene uncharacterized LOC105604155 Neighboring gene DEAF1 transcription factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056074.1 Chromosome 21 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8-like protein 2
Names
EPS8 like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056074.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    46997109..47015406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027959948.2 → XP_027815749.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A835ZL76
    Related
    ENSOARP00020017060.1, ENSOART00020020605.2
    Conserved Domains (3) summary
    cd09540
    Location:621 → 686
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:497 → 547
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_027959947.2 → XP_027815748.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A835ZL76
    Related
    ENSOARP00020048561.1, ENSOART00020054225.1
    Conserved Domains (3) summary
    cd09540
    Location:621 → 686
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:497 → 547
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_042237790.1 → XP_042093724.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A835ZL76
    Conserved Domains (3) summary
    cd09540
    Location:621 → 686
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:497 → 547
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48 → 178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_060404176.1 → XP_060260159.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A835ZL76

  5. XM_027959950.2 → XP_027815751.1  epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A835ZL76
    Related
    ENSOARP00020017131.2, ENSOART00020020691.2
Nucleotide Protein Strain
Heading Accession and Version

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