SPTBN2 spectrin beta, non-erythrocytic 2 [Felis catus (domestic cat)] - Gene

Summary

Official Symbol: SPTBN2
Official Full Name: spectrin beta, non-erythrocytic 2
Primary source: VGNC:VGNC:65660
See related: EnsemblRapid:ENSFCTG00005034067
Gene type: protein coding
RefSeq status: MODEL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: D1

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	D1	NC_058377.1 (109434813..109487901, complement)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	D1	NC_018732.3 (111669800..111709609, complement)

Chromosome D1 - NC_058377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of spectrin	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: spectrin beta chain, non-erythrocytic 2; spectrin beta, non-erythrocytic 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

NC_058377.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

Range

109434813..109487901 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_045039583.1 → XP_044895518.1 spectrin beta chain, non-erythrocytic 2 isoform X3

UniProtKB/TrEMBL

M3W7N6

Related

ENSFCTP00005062131.1, ENSFCTT00005093644.1

Conserved Domains (6) summary

smart00150
Location:2018 → 2075

SPEC; Spectrin repeats

cd00176
Location:1384 → 1588

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2221 → 2324

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:429 → 522

Spectrin; Spectrin repeat

cd21246
Location:43 → 159

CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21321
Location:173 → 291

CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
XM_011287044.4 → XP_011285346.2 spectrin beta chain, non-erythrocytic 2 isoform X3

UniProtKB/TrEMBL

M3W7N6

Conserved Domains (6) summary

smart00150
Location:2018 → 2075

SPEC; Spectrin repeats

cd00176
Location:1384 → 1588

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2221 → 2324

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:429 → 522

Spectrin; Spectrin repeat

cd21246
Location:43 → 159

CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21321
Location:173 → 291

CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
XM_023240087.2 → XP_023095855.2 spectrin beta chain, non-erythrocytic 2 isoform X3

UniProtKB/TrEMBL

M3W7N6

Related

ENSFCTP00005062126.1, ENSFCTT00005093639.1

Conserved Domains (6) summary

smart00150
Location:2018 → 2075

SPEC; Spectrin repeats

cd00176
Location:1384 → 1588

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2221 → 2324

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:429 → 522

Spectrin; Spectrin repeat

cd21246
Location:43 → 159

CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21321
Location:173 → 291

CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins
XM_019812716.3 → XP_019668275.2 spectrin beta chain, non-erythrocytic 2 isoform X1

UniProtKB/TrEMBL

M3W7N6

Conserved Domains (4) summary

smart00150
Location:442 → 535

SPEC; Spectrin repeats

COG5069
Location:64 → 454

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:1397 → 1601

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2234 → 2337

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
XM_011287043.4 → XP_011285345.2 spectrin beta chain, non-erythrocytic 2 isoform X2

UniProtKB/TrEMBL

A0A2I2U9P4

Related

ENSFCTP00005062119.1, ENSFCTT00005093631.1

Conserved Domains (6) summary

smart00150
Location:2025 → 2082

SPEC; Spectrin repeats

cd00176
Location:1391 → 1595

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:2228 → 2331

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00435
Location:436 → 529

Spectrin; Spectrin repeat

cd21246
Location:52 → 166

CH_SPTB-like_rpt1; first calponin homology (CH) domain found in the beta-I spectrin-like subfamily

cd21321
Location:180 → 298

CH_SPTBN2_rpt2; second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins