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PSEN2 presenilin 2 [ Felis catus (domestic cat) ]

Gene ID: 101081693, updated on 17-Aug-2024

Summary

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Official Symbol
PSEN2
Official Full Name
presenilin 2
Primary source
VGNC:VGNC:69101
See related
EnsemblRapid:ENSFCTG00005008524
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: F1
Exon count:
13
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) F1 NC_058384.1 (2663042..2686029)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) F1 NC_018739.3 (4685456..4708467)

Chromosome F1 - NC_058384.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC123382733 Neighboring gene stum, mechanosensory transduction mediator homolog Neighboring gene inositol-trisphosphate 3-kinase B Neighboring gene uncharacterized LOC123382935 Neighboring gene coenzyme Q8A Neighboring gene CDC42 binding protein kinase alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequencing and comparative genomic analysis of 1227 Felis catus cDNA sequences enriched for developmental, clinical and nutritional phenotypes. Irizarry KJ, et al. BMC Genomics, 2012 Jan 18. PMID 22257742, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-2
Names
presenilin 2 (Alzheimer disease 4)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058384.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    2663042..2686029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023247309.2 → XP_023103077.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A337S8T8
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 455
    Presenilin

  2. XM_023247308.2 → XP_023103076.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A337S8T8
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 455
    Presenilin

  3. XM_019821462.3 → XP_019677021.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A337S8T8
    Related
    ENSFCTP00005015560.1, ENSFCTT00005023816.1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  4. XM_019821463.3 → XP_019677022.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A337S8T8
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 455
    Presenilin

  5. XM_019821464.3 → XP_019677023.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A337S8T8
    Related
    ENSFCTP00005015602.1, ENSFCTT00005023888.1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 455
    Presenilin
Nucleotide Protein
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