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EPAS1 endothelial PAS domain protein 1 [ Saimiri boliviensis (Bolivian squirrel monkey) ]

Gene ID: 101052563, updated on 8-Mar-2024

Summary

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Gene symbol
EPAS1
Gene description
endothelial PAS domain protein 1
See related
EnsemblRapid:ENSSBOG00000022669
Gene type
protein coding
RefSeq status
MODEL
Organism
Saimiri boliviensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Saimiriinae; Saimiri
Orthologs
human mouse all
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Genomic context

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See EPAS1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
16
Annotation release Status Assembly Chr Location
102 current BCM_Sbol_2.0 (GCF_016699345.1) Unplaced Scaffold NW_024100918.1 (101902208..101989370, complement)

NW_024100918.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit E2 Neighboring gene transmembrane protein 247 Neighboring gene ras-related protein Rab-5C-like Neighboring gene protein kinase C epsilon

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_024100918 Unplaced Scaffold Reference BCM_Sbol_2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
endothelial PAS domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Saimiri boliviensis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCM_Sbol_2.0 Primary Assembly

Genomic

  1. NW_024100918.1 Reference BCM_Sbol_2.0 Primary Assembly

    Range
    101902208..101989370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003926750.3 → XP_003926799.1  endothelial PAS domain-containing protein 1

    UniProtKB/TrEMBL
    A0A2K6SWJ6
    Related
    ENSSBOP00000011746.1, ENSSBOT00000028532.2
    Conserved Domains (6) summary
    smart00091
    Location:86 → 147
    PAS; PAS domain
    cd00083
    Location:12 → 68
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:241 → 340
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:254 → 341
    PAS_3; PAS fold
    pfam08778
    Location:830 → 866
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:514 → 546
    HIF-1; Hypoxia-inducible factor-1
Nucleotide Protein
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