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NEFL neurofilament light chain [ Canis lupus familiaris (dog) ]

Gene ID: 100856220, updated on 8-Mar-2024

Summary

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Official Symbol
NEFLprovided by VGNC
Official Full Name
neurofilament light chainprovided by VGNC
Primary source
VGNC:VGNC:43724
See related
Ensembl:ENSCAFG00845014438
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See NEFL in Genome Data Viewer
Location:
chromosome: 25
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (32662329..32667982)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (33046764..33052425)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (32633319..32638980)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (32617778..32623430)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (32467208..32472860)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC111092438 Neighboring gene neurofilament medium chain Neighboring gene proteasome subunit alpha type-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog. Perino J, et al. Neurosci Lett, 2021 Jan 23. PMID 33359734, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog.
    Title: Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural constituent of postsynaptic intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in neurofilament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: neurofilament light polypeptide; neurofilament light polypeptide
Names
neurofilament, light polypeptide 68kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    32662329..32667982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435391.1 → XP_038291319.1  neurofilament light polypeptide

    UniProtKB/TrEMBL
    A0A8C0QZW7, A0A8C0TAX3, A0A8I3NI39, A0A8P0SE45
    Related
    ENSCAFP00845020363.1, ENSCAFT00845025840.1
    Conserved Domains (2) summary
    pfam00038
    Location:89 → 400
    Filament; Intermediate filament protein
    pfam04732
    Location:9 → 88
    Filament_head; Intermediate filament head (DNA binding) region

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    32617778..32623430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510330.1 → XP_038366258.1  neurofilament light polypeptide

    Conserved Domains (2) summary
    pfam00038
    Location:89 → 400
    Filament; Intermediate filament protein
    pfam04732
    Location:9 → 88
    Filament_head; Intermediate filament head (DNA binding) region

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    32467208..32472860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638097.1 → XP_038494025.1  neurofilament light polypeptide

    Conserved Domains (2) summary
    pfam00038
    Location:89 → 400
    Filament; Intermediate filament protein
    pfam04732
    Location:9 → 88
    Filament_head; Intermediate filament head (DNA binding) region

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    32633319..32638980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038573781.1 → XP_038429709.1  neurofilament light polypeptide

    UniProtKB/TrEMBL
    A0A8C0QZW7, A0A8C0TAX3, A0A8I3NI39, A0A8P0SE45
    Conserved Domains (2) summary
    pfam00038
    Location:89 → 400
    Filament; Intermediate filament protein
    pfam04732
    Location:9 → 88
    Filament_head; Intermediate filament head (DNA binding) region

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    33046764..33052425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003639880.5 → XP_003639928.2  LOW QUALITY PROTEIN: neurofilament light polypeptide

    UniProtKB/TrEMBL
    A0A8P0SE45
    Conserved Domains (2) summary
    pfam00038
    Location:89 → 400
    Filament; Intermediate filament protein
    pfam04732
    Location:9 → 88
    Filament_head; Intermediate filament head (DNA binding) region
Nucleotide Protein
Heading Accession and Version

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