Kcnn3 potassium calcium-activated channel subfamily N member 3 [Cavia porcellus (domestic guinea pig)] - Gene

Summary

Gene symbol: Kcnn3
Gene description: potassium calcium-activated channel subfamily N member 3
See related: Ensembl:ENSCPOG00000015718
Gene type: protein coding
RefSeq status: MODEL
Organism: Cavia porcellus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	mCavPor4.1 (GCF_034190915.1)	Unplaced Scaffold	NW_026947489.1 (40271617..40426277)
103	previous assembly	Cavpor3.0 (GCF_000151735.1)	Unplaced Scaffold	NT_176409.1 (15653764..15799458, complement)

NW_026947489.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Properties of SK3 channel-expressing PDGFRalpha (+) cells in the rodent urinary bladder
Title: Properties of SK3 channel-expressing PDGFRα (+) cells in the rodent urinary bladder.
SK3 channels were localized in heart ventricle mitochondria. A splice variant SK3.1 was found in ventricular cells. CaCl2 induced mK(+) influx. There was a greater fall in membrane potential (DeltaPsim), and enhanced cell death with simulated cell injury after silencing SK3.1 with siRNA.Agonists protected against ischemia-reperfusion injury in isolated hearts.
Title: Identity and function of a cardiac mitochondrial small conductance Ca(2+)-activated K(+) channel splice variant.
Orai1 physically associated with SK3 to form a signaling complex in gallbladder smooth muscle. Ca(2+) entry via Orai1 activates SK3, resulting in membrane hyperpolarization in gallbladder smooth muscle.
Title: Orai1 forms a signal complex with SK3 channel in gallbladder smooth muscle.

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General gene information

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Markers

D2Wox58 (e-PCR)
- UniSTS:240055

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables small conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: small conductance calcium-activated potassium channel protein 3

Names: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

NW_026947489.1 Reference mCavPor4.1

Range

40271617..40426277

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063250434.1 → XP_063106504.1 small conductance calcium-activated potassium channel protein 3 isoform X2
XM_003475583.5 → XP_003475631.1 small conductance calcium-activated potassium channel protein 3 isoform X1

UniProtKB/TrEMBL

H0VU03

Related

ENSCPOP00000014172.3

Conserved Domains (5) summary

pfam02888
Location:550 → 622

CaMBD; Calmodulin binding domain

pfam03530
Location:262 → 369

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:457 → 536

Ion_trans_2; Ion channel

pfam14618
Location:79 → 166

DUF4452; Domain of unknown function (DUF4452)

cl09111
Location:584 → 662

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_013158996.3 → XP_013014450.1 small conductance calcium-activated potassium channel protein 3 isoform X3

See identical proteins and their annotated locations for XP_013014450.1

Conserved Domains (4) summary

pfam02888
Location:248 → 320

CaMBD; Calmodulin binding domain

pfam03530
Location:1 → 67

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:155 → 234

Ion_trans_2; Ion channel

cl09111
Location:282 → 360

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...