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PLEKHF1 pleckstrin homology and FYVE domain containing 1 [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100666952, updated on 11-Apr-2024

Summary

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Gene symbol
PLEKHF1
Gene description
pleckstrin homology and FYVE domain containing 1
See related
EnsemblRapid:ENSLAFG00000036906
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Orthologs
human mouse all
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Genomic context

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See PLEKHF1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 21 NC_087362.1 (72588308..72598914, complement)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573463.1 (13400286..13410873, complement)

Chromosome 21 - NC_087362.1Genomic Context describing neighboring genes Neighboring gene cyclin E1 Neighboring gene chromosome 21 C19orf12 homolog Neighboring gene POP4 homolog, ribonuclease P/MRP subunit Neighboring gene V-set and transmembrane domain containing 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosome to lysosome transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pleckstrin homology domain-containing family F member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087362.1 Reference mLoxAfr1.hap2

    Range
    72588308..72598914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010596127.2 → XP_010594429.1  pleckstrin homology domain-containing family F member 1

    UniProtKB/TrEMBL
    G3UCB5
    Related
    ENSLAFP00000030420.1, ENSLAFT00000061098.1
    Conserved Domains (3) summary
    cd01218
    Location:7 → 129
    PH_Phafin2-like; Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain
    cd15754
    Location:148 → 211
    FYVE_PKHF1; FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1) and similar proteins
    pfam00169
    Location:39 → 131
    PH; PH domain

  2. XM_064274119.1 → XP_064130189.1  pleckstrin homology domain-containing family F member 1

    Related
    ENSLAFP00000040412.1, ENSLAFT00000063623.1
Nucleotide Protein
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