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VPS4A vacuolar protein sorting 4 homolog A [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100661089, updated on 11-Apr-2024

Summary

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Gene symbol
VPS4A
Gene description
vacuolar protein sorting 4 homolog A
See related
EnsemblRapid:ENSLAFG00000008828
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 21 NC_087362.1 (48475222..48486670, complement)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573468.1 (10516234..10527669)

Chromosome 21 - NC_087362.1Genomic Context describing neighboring genes Neighboring gene nucleolar pre-rRNA processing protein NIP7 Neighboring gene component of oligomeric golgi complex 8 Neighboring gene peptide deformylase, mitochondrial Neighboring gene syntrophin beta 2 Neighboring gene uncharacterized LOC135228366 Neighboring gene UTP4 small subunit processome component Neighboring gene chromosome transmission fidelity factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vacuole organization IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087362.1 Reference mLoxAfr1.hap2

    Range
    48475222..48486670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023556612.2 → XP_023412380.1  vacuolar protein sorting-associated protein 4A isoform X2

    UniProtKB/TrEMBL
    G3T2L5
    Conserved Domains (2) summary
    COG0464
    Location:26 → 347
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:373 → 433
    Vps4_C; Vps4 C terminal oligomerization domain

  2. XM_023556613.2 → XP_023412381.1  vacuolar protein sorting-associated protein 4A isoform X3

    UniProtKB/TrEMBL
    G3T2L5
    Conserved Domains (3) summary
    COG0464
    Location:13 → 288
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam09336
    Location:314 → 374
    Vps4_C; Vps4 C terminal oligomerization domain
    cl00299
    Location:1 → 19
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

  3. XM_003417046.4 → XP_003417094.1  vacuolar protein sorting-associated protein 4A isoform X1

    UniProtKB/TrEMBL
    G3T2L5, G3U2Q7
    Related
    ENSLAFP00000022115.1, ENSLAFT00000033269.2
    Conserved Domains (5) summary
    cd02678
    Location:4 → 79
    MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
    PTZ00454
    Location:4 → 348
    PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
    pfam00004
    Location:163 → 293
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:374 → 434
    Vps4_C; Vps4 C terminal oligomerization domain
    cl21455
    Location:126 → 182
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version

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