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SCN5A sodium voltage-gated channel alpha subunit 5 [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100598395, updated on 8-Mar-2024

Summary

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Gene symbol
SCN5A
Gene description
sodium voltage-gated channel alpha subunit 5
See related
EnsemblRapid:ENSNLEG00000005433
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
29
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 4 NC_044384.1 (112845500..112946848)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 4 NC_019819.1 (113671539..113911667)

Chromosome 4 - NC_044384.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene sodium voltage-gated channel alpha subunit 11 Neighboring gene sodium voltage-gated channel alpha subunit 10 Neighboring gene uncharacterized LOC115834811 Neighboring gene uncharacterized LOC115834810 Neighboring gene 60S ribosomal protein L18a pseudogene Neighboring gene exo/endonuclease G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in AV node cell action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of atrial cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium channel protein type 5 subunit alpha
Names
sodium channel, voltage-gated, type V, alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044384.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    112845500..112946848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030812108.1 → XP_030667968.1  sodium channel protein type 5 subunit alpha isoform X8

    UniProtKB/TrEMBL
    G1R080
    Conserved Domains (5) summary
    cd13433
    Location:1470 → 1522
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1203 → 1478
    Ion_trans; Ion transport protein
    pfam06512
    Location:953 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:485 → 667
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1761 → 1808
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_030812107.1 → XP_030667967.1  sodium channel protein type 5 subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A2I3HCX8

  3. XM_030812110.1 → XP_030667970.1  sodium channel protein type 5 subunit alpha isoform X10

    UniProtKB/TrEMBL
    A0A2I3I0G5
    Related
    ENSNLEP00000049280.2, ENSNLET00000042638.2
    Conserved Domains (5) summary
    cd13433
    Location:1417 → 1469
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1150 → 1425
    Ion_trans; Ion transport protein
    pfam06512
    Location:953 → 1146
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:485 → 667
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1740 → 1787
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_030812101.1 → XP_030667961.1  sodium channel protein type 5 subunit alpha isoform X2

    UniProtKB/TrEMBL
    G1R080
    Related
    ENSNLEP00000006601.3, ENSNLET00000006933.4
    Conserved Domains (5) summary
    cd13433
    Location:1471 → 1523
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1479
    Ion_trans; Ion transport protein
    pfam06512
    Location:953 → 1200
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:485 → 667
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1794 → 1841
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_030812106.1 → XP_030667966.1  sodium channel protein type 5 subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A2I3HCX8
    Related
    ENSNLEP00000041357.2, ENSNLET00000057277.2

  6. XM_030812100.1 → XP_030667960.1  sodium channel protein type 5 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2I3HR86
    Related
    ENSNLEP00000046108.2, ENSNLET00000056583.2
    Conserved Domains (5) summary
    cd13433
    Location:1471 → 1523
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1204 → 1479
    Ion_trans; Ion transport protein
    pfam06512
    Location:953 → 1200
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:485 → 667
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1794 → 1841
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. XM_030812102.1 → XP_030667962.1  sodium channel protein type 5 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A2I3HR86
    Conserved Domains (5) summary
    cd13433
    Location:1470 → 1522
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1203 → 1478
    Ion_trans; Ion transport protein
    pfam06512
    Location:953 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:485 → 667
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1793 → 1840
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. XM_030812103.1 → XP_030667963.1  sodium channel protein type 5 subunit alpha isoform X4

    UniProtKB/TrEMBL
    G1R080
    Conserved Domains (5) summary
    cd13433
    Location:1470 → 1522
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1203 → 1478
    Ion_trans; Ion transport protein
    pfam06512
    Location:953 → 1199
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:485 → 667
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1793 → 1840
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. XM_030812105.1 → XP_030667965.1  sodium channel protein type 5 subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A2I3HR86

  10. XM_030812109.1 → XP_030667969.1  sodium channel protein type 5 subunit alpha isoform X9

    UniProtKB/TrEMBL
    A0A2I3I0G5
    Conserved Domains (5) summary
    cd13433
    Location:1417 → 1469
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1150 → 1425
    Ion_trans; Ion transport protein
    pfam06512
    Location:953 → 1146
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:485 → 667
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1740 → 1787
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein
Heading Accession and Version

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