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FARP2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100584802, updated on 8-Mar-2024

Summary

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Gene symbol
FARP2
Gene description
FERM, ARH/RhoGEF and pleckstrin domain protein 2
See related
EnsemblRapid:ENSNLEG00000013956
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22a
Exon count:
28
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 22a NC_044402.1 (141703930..141844997)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 22a NC_019837.1 (132481887..132629410)

Chromosome 22a - NC_044402.1Genomic Context describing neighboring genes Neighboring gene high density lipoprotein binding protein Neighboring gene septin 2 Neighboring gene BTB/POZ domain-containing protein KCTD5 pseudogene Neighboring gene serine/threonine kinase 25 Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene THAP domain containing 4 Neighboring gene autophagy related 4B cysteine peptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
FERM, ARHGEF and pleckstrin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044402.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    141703930..141844997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030803359.1 → XP_030659219.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A2I3GT89
    Conserved Domains (7) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    PHA03307
    Location:378 → 529
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:537 → 720
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:749 → 862
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:935 → 1056
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)

  2. XM_030803361.1 → XP_030659221.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A2I3GT89
    Conserved Domains (7) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    PHA03307
    Location:378 → 529
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:537 → 720
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:749 → 862
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:935 → 1032
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)

  3. XM_030803360.1 → XP_030659220.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3GT89
    Conserved Domains (7) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    PHA03307
    Location:378 → 529
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:537 → 720
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:749 → 855
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:928 → 1049
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)

  4. XM_030803362.1 → XP_030659222.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A2I3GT89
    Related
    ENSNLEP00000034541.2, ENSNLET00000045673.2
    Conserved Domains (7) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    PHA03307
    Location:378 → 529
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:537 → 720
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:749 → 855
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:928 → 1025
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)

RNA

  1. XR_004027910.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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