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POLA1 DNA polymerase alpha 1, catalytic subunit [ Ailuropoda melanoleuca (giant panda) ]

Gene ID: 100466514, updated on 8-Mar-2024

Summary

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Gene symbol
POLA1
Gene description
DNA polymerase alpha 1, catalytic subunit
Locus tag
PANDA_016394
See related
Ensembl:ENSAMEG00000014758
Gene type
protein coding
RefSeq status
MODEL
Organism
Ailuropoda melanoleuca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda
Orthologs
human mouse all
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Genomic context

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See POLA1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
38
Annotation release Status Assembly Chr Location
103 current ASM200744v2 (GCF_002007445.1) X NC_048238.1 (20605030..20898800)
102 previous assembly AilMel_1.0 (GCF_000004335.2) Unplaced Scaffold NW_003218423.1 (62020..355103, complement)

Chromosome X - NC_048238.1Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase kinase 3 Neighboring gene phosphate cytidylyltransferase 1B, choline Neighboring gene small Cajal body-specific RNA 24 Neighboring gene aristaless related homeobox Neighboring gene uncharacterized LOC117797367

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables purine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyrimidine nucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lagging strand elongation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leading strand elongation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase alpha catalytic subunit
Names
polymerase (DNA directed), alpha 1, catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ailuropoda melanoleuca Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM200744v2 Primary Assembly

Genomic

  1. NC_048238.1 Reference ASM200744v2 Primary Assembly

    Range
    20605030..20898800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011234119.3 → XP_011232421.1  DNA polymerase alpha catalytic subunit isoform X1

    UniProtKB/TrEMBL
    D2HVJ4, G1M8F8
    Related
    ENSAMEP00000015628.2, ENSAMET00000016280.2
    Conserved Domains (5) summary
    cd05776
    Location:541 → 773
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:838 → 1248
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:56 → 1231
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:1271 → 1460
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:41 → 101
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal

  2. XM_034648774.1 → XP_034504665.1  DNA polymerase alpha catalytic subunit isoform X2

    UniProtKB/TrEMBL
    D2HVJ4
Nucleotide Protein
Heading Accession and Version

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