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mid2.L midline 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100463497, updated on 11-Apr-2024

Summary

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Official Symbol
mid2.L
Official Full Name
midline 2 L homeolog
Primary source
Xenbase:XB-GENE-6486339
Locus tag
XELAEV_18038490mg
See related
EnsemblRapid:ENSXLAG00005032802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fxy2; mid2; rnf60; trim1
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Genomic context

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Location:
chromosome: 8L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (28202160..28393468, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (13387192..13570817)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 239 Neighboring gene chloride channel, voltage-sensitive 5 L homeolog Neighboring gene serine/threonine-protein kinase N2-like Neighboring gene uncharacterized LOC121396927 Neighboring gene serine/threonine-protein kinase N2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization. Suzuki M, et al. Development, 2010 Jul. PMID 20534674

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein localization to microtubule IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
midline 2 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190884.1 → NP_001177813.1  midline 2 L homeolog

    See identical proteins and their annotated locations for NP_001177813.1

    Status: PROVISIONAL

    Source sequence(s)
    GU362930
    UniProtKB/TrEMBL
    D8WX03
    Related
    ENSXLAP00005098353.1, ENSXLAT00005100166.1
    Conserved Domains (5) summary
    smart00060
    Location:382 → 471
    FN3; Fibronectin type 3 domain
    cd00021
    Location:175 → 212
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:9 → 63
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd13739
    Location:486 → 655
    SPRY_PRY_TRIM1; PRY/SPRY domain of tripartite motif-binding protein 1 (TRIM1) or MID2
    cl23765
    Location:219 → 338
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    28202160..28393468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041571881.1 → XP_041427815.1  midline 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8F6M8, A0A974C652
    Conserved Domains (8) summary
    smart00502
    Location:219 → 338
    BBC; B-Box C-terminal domain
    smart00060
    Location:382 → 471
    FN3; Fibronectin type 3 domain
    cd13739
    Location:486 → 655
    SPRY_PRY_TRIM1; PRY/SPRY domain of tripartite motif-binding protein 1 (TRIM1) or MID2
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19823
    Location:173 → 212
    Bbox2_MID2_C-I; B-box-type 2 zinc finger found in midline-2 (MID2) and similar proteins
    cd19837
    Location:115 → 167
    Bbox1_MID2_C-I; B-box-type 1 zinc finger found in midline-2 (MID2) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl17238
    Location:10 → 62
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_041571880.1 → XP_041427814.1  midline 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8F6M8, A0A974C652
    Conserved Domains (8) summary
    smart00502
    Location:219 → 338
    BBC; B-Box C-terminal domain
    smart00060
    Location:382 → 471
    FN3; Fibronectin type 3 domain
    cd13739
    Location:486 → 655
    SPRY_PRY_TRIM1; PRY/SPRY domain of tripartite motif-binding protein 1 (TRIM1) or MID2
    cd00162
    Location:10 → 59
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19823
    Location:173 → 212
    Bbox2_MID2_C-I; B-box-type 2 zinc finger found in midline-2 (MID2) and similar proteins
    cd19837
    Location:115 → 167
    Bbox1_MID2_C-I; B-box-type 1 zinc finger found in midline-2 (MID2) and similar proteins
    pfam18568
    Location:323 → 374
    COS; TRIM C-terminal subgroup One Signature domain
    cl17238
    Location:10 → 62
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_041571882.1 → XP_041427816.1  midline 2 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1LEF2
    Conserved Domains (6) summary
    smart00502
    Location:219 → 338
    BBC; B-Box C-terminal domain
    smart00060
    Location:382 → 471
    FN3; Fibronectin type 3 domain
    cd19823
    Location:173 → 212
    Bbox2_MID2_C-I; B-box-type 2 zinc finger found in midline-2 (MID2) and similar proteins
    cd19837
    Location:115 → 167
    Bbox1_MID2_C-I; B-box-type 1 zinc finger found in midline-2 (MID2) and similar proteins
    cl02614
    Location:486 → 552
    SPRY; SPRY domain
    cl17238
    Location:10 → 62
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version

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