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PCSK9 proprotein convertase subtilisin/kexin type 9 [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100395116, updated on 6-Jun-2024

Summary

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Gene symbol
PCSK9
Gene description
proprotein convertase subtilisin/kexin type 9
See related
Ensembl:ENSCJAG00000015682
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Also known as
PC9
Orthologs
human mouse all
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Genomic context

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See PCSK9 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 7 NC_071448.1 (89242670..89268321)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 7 NC_048389.1 (90726854..90750721)

Chromosome 7 - NC_071448.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108592748 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene ubiquitin specific peptidase 24 Neighboring gene glycogenin-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species. Ding K, et al. PLoS One, 2007 Oct 31. PMID 17971861, Free PMC Article
  2. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Maudhoo MD, et al. Gigascience, 2014. PMID 25243066, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 9
Names
Proprotein convertase 9
Subtilisin/kexin-like protease PC9
convertase subtilisin/kexin type 9 preproprotein
proprotein convertase subtilisin/kexin type 9 preproprotein
NP_001254682.1
XP_017829420.3
XP_054114375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267753.1 → NP_001254682.1  proprotein convertase subtilisin/kexin type 9 precursor

    See identical proteins and their annotated locations for NP_001254682.1

    Status: PROVISIONAL

    Source sequence(s)
    EF692506
    UniProtKB/Swiss-Prot
    A8T688
    UniProtKB/TrEMBL
    F7B3I1
    Related
    ENSCJAP00000028978.1, ENSCJAT00000030620.1
    Conserved Domains (3) summary
    cd04077
    Location:154 → 419
    Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
    pfam00082
    Location:178 → 420
    Peptidase_S8; Subtilase family
    pfam05922
    Location:75 → 147
    Inhibitor_I9; Peptidase inhibitor I9

RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071448.1 Reference mCalJa1.2.pat.X

    Range
    89242670..89268321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054258400.1 → XP_054114375.1  proprotein convertase subtilisin/kexin type 9 isoform X1

    UniProtKB/TrEMBL
    F7B3I1

  2. XM_017973931.3 → XP_017829420.3  proprotein convertase subtilisin/kexin type 9 isoform X2

    UniProtKB/TrEMBL
    F7B3I1, U3EBH5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8T688.1 GenPept UniProtKB/Swiss-Prot:A8T688

Gene LinkOut

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