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CYP2D19 Cytochrome P450 2D19 [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100385343, updated on 8-Mar-2024

Summary

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Gene symbol
CYP2D19
Gene description
Cytochrome P450 2D19
See related
Ensembl:ENSCJAG00000002321
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Also known as
CYP2D6; CYPIID19
Orthologs
human all
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Genomic context

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Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 1 NC_071442.1 (186730711..186734906)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 1 NC_048383.1 (187894890..187899149)

Chromosome 1 - NC_071442.1Genomic Context describing neighboring genes Neighboring gene transcription factor 20 Neighboring gene basic proline-rich protein-like Neighboring gene cytochrome P450 2D6 Neighboring gene uncharacterized LOC103790837 Neighboring gene RING-box protein 2-like Neighboring gene 4-trimethylaminobutyraldehyde dehydrogenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan. Uehara S, et al. Xenobiotica, 2015. PMID 25801057
  2. Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs. Igarashi T, et al. Arch Biochem Biophys, 1997 Mar 1. PMID 9056237
  3. Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion. Yasukochi Y, et al. Genome Biol Evol, 2015 Mar 25. PMID 25808902, Free PMC Article
  4. Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function. Uno Y, et al. Drug Metab Rev, 2011 Aug. PMID 21303270
  5. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Maudhoo MD, et al. Gigascience, 2014. PMID 25243066, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in xenobiotic metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 2D19
Names
Cytochrome P450 CM2D-1
cytochrome P450 2D6
NP_001191367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204438.1 → NP_001191367.1  cytochrome P450 2D19

    See identical proteins and their annotated locations for NP_001191367.1

    Status: PROVISIONAL

    Source sequence(s)
    D29822
    UniProtKB/Swiss-Prot
    O18992
    UniProtKB/TrEMBL
    A0A171P0Z0, Q865W1
    Related
    ENSCJAP00000004200.2, ENSCJAT00000004428.2
    Conserved Domains (1) summary
    pfam00067
    Location:45 → 493
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071442.1 Reference mCalJa1.2.pat.X

    Range
    186730711..186734906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18992.1 GenPept UniProtKB/Swiss-Prot:O18992

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.