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gng12b guanine nucleotide binding protein (G protein), gamma 12b [ Danio rerio (zebrafish) ]

Gene ID: 100331581, updated on 27-Mar-2024

Summary

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Official Symbol
gng12bprovided by ZNC
Official Full Name
guanine nucleotide binding protein (G protein), gamma 12bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091020-2
See related
Ensembl:ENSDARG00000098123 AllianceGenome:ZFIN:ZDB-GENE-091020-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-44g17.6
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See gng12b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (23953379..24053774, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (23855158..23953914, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene SEC16 homolog B, endoplasmic reticulum export factor Neighboring gene growth arrest and DNA-damage-inducible, alpha, b Neighboring gene down-regulator of transcription 1 Neighboring gene zgc:109982

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in the zebrafish. Mulligan T, et al. Cell Signal, 2010 Feb. PMID 19786091, Free PMC Article
  2. Distinct requirements for Wntless in habenular development. Kuan YS, et al. Dev Biol, 2015 Oct 15. PMID 26116173, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    23953379..24053774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477104.1 → XP_021332779.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like

    UniProtKB/TrEMBL
    A0A0R4IHM6, A0A8M9QFZ7
    Related
    ENSDARP00000133096.1, ENSDART00000168511.2
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  2. XM_021477105.1 → XP_021332780.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like

    UniProtKB/TrEMBL
    A0A0R4IHM6, A0A8M9QFZ7
    Related
    ENSDARP00000150753.1, ENSDART00000186164.1
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394640.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    167775..260611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002662418.5 → XP_002662464.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like

    See identical proteins and their annotated locations for XP_002662464.1

    UniProtKB/TrEMBL
    A0A0R4IHM6, A0A8M9QFZ7
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  2. XM_005168746.4 → XP_005168803.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like

    See identical proteins and their annotated locations for XP_005168803.1

    UniProtKB/TrEMBL
    A0A0R4IHM6, A0A8M9QFZ7
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs
Nucleotide Protein Strain
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