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GDF9 growth differentiation factor 9 [ Ovis aries (sheep) ]

Gene ID: 100217402, updated on 8-Mar-2024

Summary

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Gene symbol
GDF9
Gene description
growth differentiation factor 9
See related
EnsemblRapid:ENSOARG00020021050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
GDF-9
Orthologs
human mouse all
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Genomic context

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See GDF9 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 5 NC_056058.1 (42113878..42116604, complement)

Chromosome 5 - NC_056058.1Genomic Context describing neighboring genes Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene shroom family member 1 Neighboring gene cytochrome b-c1 complex subunit 8 Neighboring gene liver enriched antimicrobial peptide 2 Neighboring gene ALF transcription elongation factor 4 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056058.1 Chromosome 5 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Influence of FecG(E) mutation on the reproductive variables of Pelibuey ewes in the anestrus period. Muñoz-García C, et al. Trop Anim Health Prod, 2021 May 17. PMID 34002300
  2. Three Complete Linkage SNPs of GDF9 Gene Affect the Litter Size Probably Mediated by OCT1 in Hu Sheep. Li Y, et al. DNA Cell Biol, 2020 Apr. PMID 32073892
  3. Evaluation of morphology, morphometry and follicular dynamics in FecGE genotyped ewes. Chaves MS, et al. Theriogenology, 2019 Sep 15. PMID 31265943
  4. Identification of point mutations in exon 2 of GDF9 gene in Kermani sheep. Khodabakhshzadeh R, et al. Pol J Vet Sci, 2016. PMID 27487501
  5. Polymorphism of the GDF9 gene associated with litter size in Araucana creole sheep. Bravo S, et al. Anim Genet, 2016 Jun. PMID 27110683

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Influence of FecG(E) mutation on the reproductive variables of Pelibuey ewes in the anestrus period.
    Title: Influence of FecG(E) mutation on the reproductive variables of Pelibuey ewes in the anestrus period.
  2. Seven polymorphisms were located in the GDF9 gene, all of which were previously reported. Among these was FecGE mutation, which is associated with an increase in ovulation rate and proli fi cacy in the Santa Ines breed.
    Title: FecG(E) mutation in pelibuey sheep.
  3. Three complete linkage single-nucleotide polymorphisms of the GDF9 gene regulate the litter size in Hu sheep probably via inhibition of the promoter activity by binding with OCT1 at -534 GG genotype and forming a complex between OCT1 and CCAAT/enhancer-binding protein (C/EBP).
    Title: Three Complete Linkage SNPs of GDF9 Gene Affect the Litter Size Probably Mediated by OCT1 in Hu Sheep.
  4. FecG(E/E) ewes demonstrated a higher number of ovulated follicles and that FecG(E/E) and FecG(+/E) ewes presented ovulatory follicles with a smaller diameter.
    Title: Evaluation of morphology, morphometry and follicular dynamics in FecGE genotyped ewes.
  5. The detection and identification of single nucleotide polymorphisms in exon 2 of GDF9 gene in Kermani sheep breed using PCR-SSCP are reported.
    Title: Identification of point mutations in exon 2 of GDF9 gene in Kermani sheep.
  6. c.978A>G and c.994G>A SNPs are genetic markers for fecundity in Araucana creole sheep
    Title: Polymorphism of the GDF9 gene associated with litter size in Araucana creole sheep.
  7. study concluded that growth differentiation factor 9 and bone morphogenic protein 15 follow stage-specific pattern of expression during the in vivo development of ovarian follicles in sheep, and in vitro culture altered these changes
    Title: Quantitative expression patterns of GDF9 and BMP15 genes in sheep ovarian follicles grown in vivo or cultured in vitro.
  8. Analysis of data on Belclare sheep revealed a significant association between V371M mutation og GDF9 and ovulation rate.
    Title: Direct evidence on the contribution of a missense mutation in GDF9 to variation in ovulation rate of Finnsheep.
  9. The Lleyn breed was the most likely source of the BMP15 FecX(G) and GDF9 FecG(H) mutations in Belclare and Cambridge sheep, and the BMP15 FecX(B) mutation came from the High Fertility line developed from prolific ewes in commercial flocks in Ireland.
    Title: Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep.
  10. GDF9 genotypes did not have any significant effect on reproduction traits in Mehraban ewes.
    Title: Association of BMPR-1B and GDF9 genes polymorphisms and secondary protein structure changes with reproduction traits in Mehraban ewes.
Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth/differentiation factor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142888.2 → NP_001136360.2  growth/differentiation factor 9 precursor

    See identical proteins and their annotated locations for NP_001136360.2

    Status: PROVISIONAL

    Source sequence(s)
    EE835073, FJ429111
    UniProtKB/Swiss-Prot
    O77681
    UniProtKB/TrEMBL
    A0A0M4MFY8, B7U471, J7QLW2, W5PUP3
    Related
    ENSOARP00020026884.1, ENSOART00020032535.2
    Conserved Domains (1) summary
    pfam00019
    Location:350 → 452
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056058.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    42113878..42116604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77681.2 GenPept UniProtKB/Swiss-Prot:O77681

Gene LinkOut

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