MAEA macrophage erythroblast attacher, E3 ubiquitin ligase [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: MAEA
Gene description: macrophage erythroblast attacher, E3 ubiquitin ligase
Locus tag: CR201_G0040894
See related: Ensembl:ENSPPYG00000014525
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	3	NC_071988.2 (1316223..1365968)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	4	NC_071989.1 (1313461..1363206)

Chromosome 3 - NC_071988.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH91095 (e-PCR)
- UniSTS:92448

HSCZXD042 (e-PCR)
- UniSTS:20892

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of GID complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein transferase MAEA

NP_001126854.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001133382.1 → NP_001126854.1 E3 ubiquitin-protein transferase MAEA

See identical proteins and their annotated locations for NP_001126854.1

Status: PROVISIONAL

Source sequence(s)

CR861046

UniProtKB/Swiss-Prot

Q5R532

UniProtKB/TrEMBL

A0A2J8SS57, A0A2J8SS63, H2PCN9

Related

ENSPPYP00000016232.3, ENSPPYT00000016887.3

Conserved Domains (3) summary

smart00667
Location:120 → 153

LisH; Lissencephaly type-1-like homology motif

cd16659
Location:336 → 383

RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins

pfam10607
Location:160 → 301

CLTH; CTLH/CRA C-terminal to LisH motif domain