EPS8L2 EPS8 signaling adaptor L2 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: EPS8L2
Gene description: EPS8 signaling adaptor L2
Locus tag: CR201_G0053100
See related: Ensembl:ENSPPYG00000030823
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Also known as: EPS8R2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	9	NC_071994.2 (595100..617704)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	11	NC_071996.1 (595375..617694)

Chromosome 9 - NC_071994.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH48240 (e-PCR)
- UniSTS:87253

RH94040 (e-PCR)
- UniSTS:89837

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in vesicle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: epidermal growth factor receptor kinase substrate 8-like protein 2

Names: EPS8 like 2; EPS8-like protein 2; EPS8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131916.1 → NP_001125388.1 epidermal growth factor receptor kinase substrate 8-like protein 2

See identical proteins and their annotated locations for NP_001125388.1

Status: PROVISIONAL

Source sequence(s)

CR858475

UniProtKB/Swiss-Prot

Q5RC07

UniProtKB/TrEMBL

A0A2J8XSA1, A0A8I5YPX8

Conserved Domains (3) summary

cd09540
Location:624 → 689

SAM_EPS8-like; SAM domain of EPS8-like subfamily

cd11764
Location:497 → 547

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:48 → 178

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_071994.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

595100..617704

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063727874.1 → XP_063583944.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q5RC07

UniProtKB/TrEMBL

A0A2J8XSA1
XM_063727879.1 → XP_063583949.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X4
XM_063727880.1 → XP_063583950.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X4
XM_024254453.3 → XP_024110221.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q5RC07

UniProtKB/TrEMBL

A0A2J8XSA1, A0A8I5YPX8

Related

ENSPPYP00000039888.1

Conserved Domains (3) summary

cd09540
Location:624 → 689

SAM_EPS8-like; SAM domain of EPS8-like subfamily

cd11764
Location:497 → 547

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:48 → 178

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
XM_063727881.1 → XP_063583951.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X4
XM_063727876.1 → XP_063583946.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q5RC07

UniProtKB/TrEMBL

A0A2J8XSA1
XM_063727877.1 → XP_063583947.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X1

UniProtKB/Swiss-Prot

Q5RC07

UniProtKB/TrEMBL

A0A2J8XSA1
XM_063727875.1 → XP_063583945.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X2
XM_063727878.1 → XP_063583948.1 epidermal growth factor receptor kinase substrate 8-like protein 2 isoform X3

UniProtKB/TrEMBL

H2NCB6