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Shmt serine hydroxymethyl transferase [ Acyrthosiphon pisum (pea aphid) ]

Gene ID: 100159628, updated on 23-May-2024

Summary

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Gene symbol
Shmt
Gene description
serine hydroxymethyl transferase
See related
EnsemblRapid:GeneID_100159628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Acyrthosiphon pisum
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha; Aphidoidea; Aphididae; Macrosiphini; Acyrthosiphon
Also known as
Shmt1
Orthologs
fruit fly all
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Genomic context

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Location:
chromosome: A1
Exon count:
9
Annotation release Status Assembly Chr Location
103 current pea_aphid_22Mar2018_4r6ur (GCF_005508785.1) A1 NC_042494.1 (53331695..53336825, complement)
102 previous assembly Acyr_2.0 (GCF_000142985.2) Unplaced Scaffold NW_003383750.1 (661511..666641, complement)

Chromosome A1 - NC_042494.1Genomic Context describing neighboring genes Neighboring gene mucin-5AC Neighboring gene eukaryotic translation initiation factor 4E-like Neighboring gene nuclear pore complex protein Nup54 Neighboring gene uncharacterized LOC107883635 Neighboring gene uncharacterized LOC115033612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyltransferase 1 (soluble)
NP_001153811.1
NP_001153812.1
NP_001153813.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160339.1 → NP_001153811.1  serine hydroxymethyltransferase 1 (soluble) isoform a

    See identical proteins and their annotated locations for NP_001153811.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    CV829502, EX604854, FF300456, FF322182, FF323695
    UniProtKB/TrEMBL
    A0A8R1XHB1
    Related
    NP_001153811.1, NM_001160339.1
    Conserved Domains (2) summary
    PLN03226
    Location:39 → 496
    PLN03226; serine hydroxymethyltransferase; Provisional
    cl18945
    Location:45 → 444
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  2. NM_001160340.1 → NP_001153812.1  serine hydroxymethyltransferase 1 (soluble) isoform a

    See identical proteins and their annotated locations for NP_001153812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    CV829502, EX604854, FF322182, FF323695
    UniProtKB/TrEMBL
    A0A8R1XHB1
    Related
    NP_001153812.1, NM_001160340.1
    Conserved Domains (2) summary
    PLN03226
    Location:39 → 496
    PLN03226; serine hydroxymethyltransferase; Provisional
    cl18945
    Location:45 → 444
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. NM_001160341.1 → NP_001153813.1  serine hydroxymethyltransferase 1 (soluble) isoform b

    See identical proteins and their annotated locations for NP_001153813.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. Isoform b has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    CV829502, FF314777, FF322182, FF323695
    UniProtKB/TrEMBL
    A0A8R1XED9
    Related
    NP_001153813.1, NM_001160341.1
    Conserved Domains (2) summary
    PLN03226
    Location:15 → 472
    PLN03226; serine hydroxymethyltransferase; Provisional
    cl18945
    Location:21 → 420
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Acyrthosiphon pisum Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference pea_aphid_22Mar2018_4r6ur Primary Assembly

Genomic

  1. NC_042494.1 Reference pea_aphid_22Mar2018_4r6ur Primary Assembly

    Range
    53331695..53336825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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