FAT1 FAT atypical cadherin 1 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: FAT1
Gene description: FAT atypical cadherin 1
See related: Ensembl:ENSSSCG00000007000
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in kidney (RPKM 15.9), lung (RPKM 14.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	17	NC_010459.5 (8466099..8580715)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	17	NC_010459.4 (9339790..9455160)

Chromosome 17 - NC_010459.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus.
Title: CRISPR/Cas9-Mediated Specific Integration of Fat-1 and IGF-1 at the pRosa26 Locus.
these data provide new insights into the mechanisms of the association between FAT1 and porcine cumulus cell apoptosis.
Title: The possible FAT1-mediated apoptotic pathways in porcine cumulus cells.
The detection limit of sFAT-1 LAMP was as low as 1.26 ng/muL. Furthermore, blind tests of transgenic and non-transgenic DNA samples were all correctly detected. Hence, the results in this study demonstrated that LAMP is a very useful tool for transgenic detection.
Title: Rapid and Sensitive Detection of sFAT-1 Transgenic Pigs by Visual Loop-Mediated Isothermal Amplification.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_56821-56822:1159969735:2 (e-PCR)
- UniSTS:508170

MARC_56823-56824:1161887017:7 (e-PCR)
- UniSTS:508171

BARC0068 (e-PCR)
- UniSTS:260475

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protocadherin Fat 1

Names: FAT tumor suppressor homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190170.1 → NP_001177099.1 protocadherin Fat 1

Status: VALIDATED

Source sequence(s)

CK449734, CU062594, CU302402

UniProtKB/TrEMBL

A0A8D0JSY5

Related

ENSSSCT00000007666.5

Conserved Domains (5) summary

cd11304
Location:3234 → 3331

Cadherin_repeat; Cadherin tandem repeat domain

smart00282
Location:3854 → 3985

LamG; Laminin G domain

cd00054
Location:4127 → 4163

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:4093 → 4123

EGF; EGF-like domain

cl09101
Location:277 → 355

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus