AQP2 aquaporin 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: AQP2provided by VGNC
Official Full Name: aquaporin 2provided by VGNC
Primary source: VGNC:VGNC:85431
See related: Ensembl:ENSSSCG00000021193
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in kidney (RPKM 42.6), mixtures (RPKM 5.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	5	NC_010447.5 (15862739..15868565)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	5	NC_010447.4 (16090821..16095902, complement)

Chromosome 5 - NC_010447.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AQP1, AQP2, and AQP3, and V2R expression increased with gestation age in the fetal kidney, suggesting that this induction might contribute to the maturation of urinary concentrating capacity
Title: Influence of sex on aquaporin1-4 and vasopressin V2 receptor expression in the pig kidney during development.
Aquaporin 2 promotes cell migration and epithelial morphogenesis.
Title: Aquaporin 2 promotes cell migration and epithelial morphogenesis.
Data provide evidence supporting the role of S256 and S269 in the maintenance of AQP2 at the cell surface.
Title: Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables water channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: aquaporin-2

Names: aquaporin 2 (collecting duct)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128476.1 → NP_001121948.1 aquaporin-2

See identical proteins and their annotated locations for NP_001121948.1

Status: PROVISIONAL

Source sequence(s)

EU636238

UniProtKB/TrEMBL

A0A480DWE7, A0A8D0I9I9, B2MW86, I3LH92

Related

ENSSSCP00000023437.3, ENSSSCT00000024769.3

Conserved Domains (1) summary

pfam00230
Location:3 → 219

MIP; Major intrinsic protein

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010447.5 Reference Sscrofa11.1 Primary Assembly

Range

15862739..15868565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021090895.1 → XP_020946554.1 aquaporin-2 isoform X1

Conserved Domains (1) summary

cl00200
Location:76 → 199

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...