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mc2r melanocortin 2 receptor [ Oncorhynchus mykiss (rainbow trout) ]

Gene ID: 100136719, updated on 8-Mar-2024

Summary

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Gene symbol
mc2r
Gene description
melanocortin 2 receptor
See related
Ensembl:ENSOMYG00000023652
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oncorhynchus mykiss
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus
Orthologs
zebrafish all
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Genomic context

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See mc2r in Genome Data Viewer
Location:
chromosome: Un
Exon count:
3
Annotation release Status Assembly Chr Location
101 current USDA_OmykA_1.1 (GCF_013265735.2) Unplaced Scaffold NW_023493694.1 (141110..143534)
100 previous assembly Omyk_1.0 (GCF_002163495.1) Unplaced Scaffold NW_018578816.1 (53..1125)

NW_023493694.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 239 Neighboring gene KIAA0947-like (H. sapiens) Neighboring gene family with sequence similarity 210 member Ab Neighboring gene low density lipoprotein receptor class A domain containing 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization, tissue-specific expression, and regulation of melanocortin 2 receptor in rainbow trout. Aluru N, et al. Endocrinology, 2008 Sep. PMID 18535097, Free PMC Article
  2. Structure/function studies on the activation of the rainbow trout melanocortin-2 receptor. Liang L, et al. Gen Comp Endocrinol, 2015 Jan 1. PMID 24709361
  3. A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss). Khan UW, et al. Sci Rep, 2016 Jul 4. PMID 27373344, Free PMC Article
  4. Analysis of steroidogenic pathway key transcripts in interrenal cells isolated by laser microdissection (LMD) in stressed rainbow trout. Fierro-Castro C, et al. Comp Biochem Physiol A Mol Integr Physiol, 2015 Dec. PMID 26358831

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Considering that mRNA for MC2R and the MC1R variants are present in head kidney cells, the authors hypothesized that MC2R activity is modulated in part by different binding affinities of the MC1R variants for MRAP.
    Title: A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss).
  2. Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: MC2R (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.
    Title: Analysis of steroidogenic pathway key transcripts in interrenal cells isolated by laser microdissection (LMD) in stressed rainbow trout.
  3. Rainbow trout melanocortin-2 receptor structure and function analysis.
    Title: Structure/function studies on the activation of the rainbow trout melanocortin-2 receptor.
  4. ACTH regulation of MC2R is highly conserved in vertebrates.
    Title: Molecular characterization, tissue-specific expression, and regulation of melanocortin 2 receptor in rainbow trout.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables melanocortin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adrenocorticotropic hormone receptor
Names
putative melanocortin 2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001124680.1 → NP_001118152.1  adrenocorticotropic hormone receptor

    See identical proteins and their annotated locations for NP_001118152.1

    Status: PROVISIONAL

    Source sequence(s)
    EU119870
    UniProtKB/TrEMBL
    A0A8C7RFY3, A7Y4C2
    Related
    ENSOMYP00000051783.2, ENSOMYT00000056315.2
    Conserved Domains (1) summary
    pfam00001
    Location:34 → 274
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Oncorhynchus mykiss Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference USDA_OmykA_1.1 Primary Assembly

Genomic

  1. NW_023493694.1 Reference USDA_OmykA_1.1 Primary Assembly

    Range
    141110..143534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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