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NCF4 neutrophil cytosolic factor 4 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009359, updated on 8-Mar-2024

Summary

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Gene symbol
NCF4
Gene description
neutrophil cytosolic factor 4
See related
Ensembl:ENSOCUG00000021337
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See NCF4 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 4 NC_067377.1 (92520483..92534131, complement)

Chromosome 4 - NC_067377.1Genomic Context describing neighboring genes Neighboring gene testis-expressed protein 33 Neighboring gene cytokine receptor common subunit beta Neighboring gene uncharacterized LOC108176677 Neighboring gene parvalbumin Neighboring gene intraflagellar transport 27

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067377.1 Chromosome 4 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and sequencing of rabbit leukocyte NADPH oxidase genes reveals a unique p67(phox) homolog. Gauss KA, et al. J Leukoc Biol, 2002 Feb. PMID 11818454

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NADPH oxidase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in respiratory burst IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neutrophil cytosol factor 4
Names
neutrophil cytosolic factor 4, 40kDa
p40-phox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082654.1 → NP_001076123.1  neutrophil cytosol factor 4

    See identical proteins and their annotated locations for NP_001076123.1

    Status: PROVISIONAL

    Source sequence(s)
    AF323790
    UniProtKB/TrEMBL
    A0A5F9CAK4, Q95MN1
    Related
    ENSOCUP00000020100.1, ENSOCUT00000029379.3
    Conserved Domains (3) summary
    cd06399
    Location:238 → 330
    PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
    cd06882
    Location:19 → 141
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cd11869
    Location:174 → 227
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067377.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    92520483..92534131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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