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ablim1a actin binding LIM protein 1a [ Danio rerio (zebrafish) ]

Gene ID: 100003558, updated on 27-Mar-2024

Summary

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Official Symbol
ablim1aprovided by ZNC
Official Full Name
actin binding LIM protein 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080219-41
See related
Ensembl:ENSDARG00000060149 AllianceGenome:ZFIN:ZDB-GENE-080219-41
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ablim1; zgc:172321
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in cilium assembly and lamellipodium assembly. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be active in stress fiber. Orthologous to human ABLIM1 (actin binding LIM protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ablim1a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (43507383..43599920, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (43373558..43470576, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene SPARC related modular calcium binding 2 Neighboring gene dishevelled-binding antagonist of beta-catenin 2 Neighboring gene FHF complex subunit HOOK interacting protein 2 Neighboring gene zinc finger, FYVE domain containing 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Candidate risk genes for bipolar disorder are highly conserved during evolution and highly interconnected. Franklin C, et al. Bipolar Disord, 2021 Jun. PMID 32959503
  2. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
  3. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC172321

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
actin-binding LIM protein 1; actin-binding LIM protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114316.1 → NP_001107788.1  actin-binding LIM protein 1a

    See identical proteins and their annotated locations for NP_001107788.1

    Status: PROVISIONAL

    Source sequence(s)
    BC155652
    UniProtKB/TrEMBL
    A9JRG6
    Related
    ENSDARP00000115616.1, ENSDART00000145705.3
    Conserved Domains (6) summary
    smart00153
    Location:658 → 693
    VHP; Villin headpiece domain
    cd09327
    Location:50 → 101
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:106 → 161
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:187 → 238
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:246 → 301
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:311 → 657
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    43507383..43599920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480477.1 → XP_021336152.1  actin-binding LIM protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PXI2
    Conserved Domains (6) summary
    smart00153
    Location:762 → 797
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:370 → 761
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. XM_021480476.1 → XP_021336151.1  actin-binding LIM protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QJF9
    Conserved Domains (6) summary
    smart00153
    Location:768 → 803
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:370 → 767
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. XM_017358666.2 → XP_017214155.1  actin-binding LIM protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8M6Z1J7

  4. XM_017358665.2 → XP_017214154.1  actin-binding LIM protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A8M6Z9H1

  5. XM_009307565.3 → XP_009305840.1  actin-binding LIM protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8M3BEV3
    Conserved Domains (6) summary
    smart00153
    Location:742 → 777
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:222 → 273
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:281 → 336
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:346 → 741
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  6. XM_009307554.3 → XP_009305829.1  actin-binding LIM protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8M3B5I2
    Conserved Domains (6) summary
    smart00153
    Location:744 → 779
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:222 → 273
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:281 → 336
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:346 → 743
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  7. XM_021480478.1 → XP_021336153.1  actin-binding LIM protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q9F1
    Conserved Domains (6) summary
    smart00153
    Location:759 → 794
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:222 → 273
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:281 → 336
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:361 → 758
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  8. XM_009307559.3 → XP_009305834.1  actin-binding LIM protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8M3AZG5
    Conserved Domains (6) summary
    smart00153
    Location:704 → 739
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:355 → 703
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  9. XM_009307552.3 → XP_009305827.1  actin-binding LIM protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3B896
    Conserved Domains (6) summary
    smart00153
    Location:753 → 788
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:355 → 752
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  10. XM_021480483.1 → XP_021336158.1  actin-binding LIM protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8M9Q9F5
    Conserved Domains (6) summary
    smart00153
    Location:689 → 724
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:370 → 688
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  11. XM_021480482.1 → XP_021336157.1  actin-binding LIM protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8M9PXI8
    Conserved Domains (6) summary
    smart00153
    Location:691 → 726
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:370 → 690
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  12. XM_021480479.1 → XP_021336154.1  actin-binding LIM protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8M9QF47
    Conserved Domains (6) summary
    smart00153
    Location:734 → 769
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:370 → 733
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  13. XM_021480481.1 → XP_021336156.1  actin-binding LIM protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8M9QJG3
    Conserved Domains (6) summary
    smart00153
    Location:717 → 752
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:370 → 716
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  14. XM_021480480.1 → XP_021336155.1  actin-binding LIM protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8M9QN76
    Conserved Domains (6) summary
    smart00153
    Location:719 → 754
    VHP; Villin headpiece domain
    cd09327
    Location:94 → 145
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:150 → 205
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:231 → 282
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:290 → 345
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:370 → 718
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  15. XM_017358667.2 → XP_017214156.1  actin-binding LIM protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8M6Z923
Nucleotide Protein
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