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    Results: 12

    1.
    Full record GDS1850

    Carious pulpal tissue

    Expression profiling of core pulpal tissue from carious teeth. RNA pooled from 11 carious teeth. Results provide insight into the molecular events that occur during the progression of dental caries.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 disease state sets
    Platform:
    GPL96
    Series:
    GSE1629
    4 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1850
    ID:
    1850
    2.

    Carious versus healthy pulp gene expression

    (Submitter supplied) Duplicate analysis of pooled healthy and carious pulpal tissue gene expression using Affymetrix HG_U133A arrays Keywords: repeat sample
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS1850
    Platform:
    GPL96
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE1629
    ID:
    200001629
    3.

    Influence of cyclical mechanical strain on global gene expression in human lamina cribrosa cells in vitro

    (Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL96
    2 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE3166
    ID:
    200003166
    4.

    Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

    (Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS1353
    Platform:
    GPL96
    12 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE3040
    ID:
    200003040
    5.
    Full record GDS1353

    Glucocorticoid effect on lens epithelial cells: time course

    Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 agent, 2 time sets
    Platform:
    GPL96
    Series:
    GSE3040
    12 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1353
    ID:
    1353
    6.

    Preovulatory ovary

    (Submitter supplied) Nylon microarrays displaying 9152 rainbow trout cDNAs were hybridized using RNA samples originating from ovarian tissue collected during late vitellogenesis, post-vitellogenesis and oocyte maturation. Differentially expressed genes were identified using a statistical analysis. A supervised clustering analysis was performed using only differentially expressed genes in order to identify gene clusters exhibiting similar expression profiles. more...
    Organism:
    Oncorhynchus mykiss
    Type:
    Expression profiling by array
    Dataset:
    GDS3163
    Platform:
    GPL3650
    13 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE4871
    ID:
    200004871
    7.
    Full record GDS3163

    Preovulatory ovaries: time course

    Analysis of fish preovulatory ovaries collected during late vitellogenesis, post-vitellogenesis and oocyte maturation. In fish, the post-vitellogenic period is critical for completion of the oogenetic process. Results provide insight into molecular events occurring during the preovulatory period.
    Organism:
    Oncorhynchus mykiss
    Type:
    Expression profiling by array, transformed count, 3 development stage sets
    Platform:
    GPL3650
    Series:
    GSE4871
    13 Samples
    Download data:
    GEO
    8.

    Gene expression profiles in synovial biopsies from patients with arthritis

    (Submitter supplied) Rheumatoid arthritis (RA) is an inflammatory joint disorder that results in progressive joint damage when insufficiently treated. In order to prevent joint destruction and functional disability in RA, early diagnosis and initiation of appropriate treatment with Disease-Modifying Antirheumatic Drugs (DMARDs) is needed. However, in daily clinical practice, patients may initially display symptoms of arthritis that do not fulfil the classification criteria for a definite diagnosis of RA, or any other joint disease, a situation called “Undifferentiated Arthritis” (UA). more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    25 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE36700
    ID:
    200036700
    9.

    Effects of TGF-β1 on expression profile of human pulp and odontoblasts

    (Submitter supplied) Transforming growth factor beta 1 (TGF-β1) is the most extensively studied growth factor in dentin-pulp complex, with pleiotropic effects on pulp response and healing. Our main objective was to analyze the expression profile of pulp tissue and odontoblasts, and the effects of TGF-β1 on these profiles in cultured human pulp and odontoblasts with a specific interest in the anti- and pro-inflammatory cytokines. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL570 GPL96
    12 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE8730
    ID:
    200008730
    10.

    Comparison of Mycobacterium bovis-infected cattle versus control non-infected cattle using the BOTL-5 microarray

    (Submitter supplied) Background: Bovine tuberculosis is an enduring disease of cattle that has significant repercussions for human health. The advent of high-throughput functional genomics technologies has facilitated large-scale analyses of the immune response to this disease that will ultimately lead to novel diagnostics and therapeutic targets. Analysis of mRNA abundance in peripheral blood mononuclear cells (PBMC) from six Mycobacterium bovis infected cattle and six non-infected controls was performed. more...
    Organism:
    Bos taurus
    Type:
    Expression profiling by array
    Platform:
    GPL5751
    12 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE8857
    ID:
    200008857
    11.

    Gene expression profiling of prostate cancer

    (Submitter supplied) To better understand the molecular mechanism that underlay tumorigenesis and progression of prostate cancer (PCa), we studied the gene expression profiles of sixteen PCa compared to their matched normal tissues. Using Significance Analysis of Microarrays, we identified 53 genes differentially expressed that were more than 2 fold up- or down-regulated in at least 50 % of the tumors. Keywords: disease state analysis
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL1998
    16 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE9347
    ID:
    200009347
    12.

    Unique Gene Expression Profiles of Donor-Matched Human Retinal and Choroidal Vascular Endothelial Cells

    (Submitter supplied) Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal and choroidal endothelial cells from 6 human cadavers were incubated with either Toxoplasma gondii tachyzoites (10:1, parasite:cell) or Escherichia coli lipopolysaccharide (100 ng/mL); control cultures were simultaneously incubated with medium. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL201
    46 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE7850
    ID:
    200007850

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