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Items: 7

1.

Single-cell Multi-omics Analysis of Human Testicular Germ Cell Tumor Reveals its Molecular Features and Microenvironment

(Submitter supplied) Seminoma is the most common malignant solid tumor in 14 to 44 year-old men. However, its molecular features and tumor microenvironment (TME) is largely unexplored. Here, we performed a series of studies via genomics profiling (single cell multi-omics and spatial transcriptomics) and functional examination using seminoma samples and a seminoma cell line. We identified key gene expression programs shared between seminoma and primordial germ cells, and further characterized the functions of TFAP2C in promoting tumor invasion and migration. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
4 Samples
Download data: TAR
Series
Accession:
GSE228501
ID:
200228501

PubMed Full text in PMC Similar studies

2.

Integrated molecular genetic profiling of pediatric-high grade gliomas reveals key differences with adult disease

(Submitter supplied) Purpose: To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). Patients and Methods: We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGG, including 7 diffuse intrinsic pontine gliomas, and 10 HGG cases arising in children who received cranial irradiation for a previous cancer, using Affymetrix 500K GeneChips. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; Expression profiling by array
Platforms:
GPL570 GPL3720 GPL3718
209 Samples
Download data: CEL
Series
Accession:
GSE19578
ID:
200019578

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

Validation Set for Prediction of Outcome in Adult Male Germ Cell Tumors

(Submitter supplied) This series represents expression profiles of 34 non-seminoma germ cell tumors (NSGCTs) from patients who received cisplatin based chemotherarpy for treatment of their disease for whom full clinical follow-up information was available. These specimens were used as a validation set to test outcome prediction models using a subset of previously profiled GCT specimens (see GEO accession #GSE3218). Keywords: Disease state analysis (good vs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL97 GPL96
68 Samples
Download data: CEL, EXP
Series
Accession:
GSE10783
ID:
200010783

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

Pediatric malignant germ cell tumors show characteristic transcriptome profiles

(Submitter supplied) To compare the transcriptome profiles of the two principal histological variants of malignant germ cell tumor that occur in childhood Keywords: Disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3262
Platform:
GPL96
27 Samples
Download data: CEL
Series
Accession:
GSE10615
ID:
200010615

PubMed Similar studies Analyze with GEO2R

5.
Full record GDS3262

Pediatric malignant germ cell tumors: yolk sac tumors and seminomas

Analysis of yolk sac tumors (YSTs) and seminomas, the two principal histological variants of pediatric malignant germ cell tumors (MGCTs). Seminomas and YSTs are presumed to arise from the same progenitor cell. Results provide insight into the molecular basis for the divergence of pediatric MGCTs.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL96
Series:
GSE10615
27 Samples
Download data: CEL
DataSet
Accession:
GDS3262
ID:
3262

PubMed Similar studies GEO Profiles Analyze DataSet

6.

Gene expression profiling of testicular seminoma

(Submitter supplied) Gene expression patterns of testicular seminoma were analysed applying oligonucleotide microarrays in 40 specimens of different tumour stages (pT1, pT2, pT3) and in 3 normal testes. Keywords: ordered
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2842
Platform:
GPL8300
43 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE8607
ID:
200008607

PubMed Full text in PMC Similar studies Analyze with GEO2R

7.
Full record GDS2842

Testicular seminoma progression

Analysis of testicular seminoma tumors at various stages of progression (pT1, pT2, pT3). Results provide insight into the pathogenesis of testicular seminoma.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL8300
Series:
GSE8607
43 Samples
Download data: CEL, CHP, EXP
DataSet
Accession:
GDS2842
ID:
2842

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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db=gds|term=%22disease%20state%22[All%20Fields]%20AND%20%22Homo%20Sapiens%22[porgn]%20AND%20(%22Germinoma%22[MeSH%20Terms]%20OR%20%22Germinoma%22[All%20Fields])%20AND%20(%22gds%22[Filter]%20OR%20%22gse%22[Filter]%20OR%20%22gsm%22[Filter])%20AND%20(%22Expression%20profiling%20by%20array%22[Filter]%20OR%20Expression%20profiling%20by%20high%20throughput%20sequencing[Filter])|query=16|qty=2|blobid=MCID_66f0f223e8f6680c6bd07095|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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