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Conserved domains on  [gi|1910408677|ref|XP_016001852|]
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NHL repeat-containing protein 2 [Rousettus aegyptiacus]

Protein Classification

similar to protein Dmel_CG12547, isoform A( domain architecture ID 10122410)

protein similar to protein Dmel_CG12547, isoform A

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 261-620 0e+00

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 551.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 261 IGGPNPGRKDGIFSESTFNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEMVSTVAGIGIQGSDKEGGAQGEEQPISSPW 339
Cdd:cd14951     1 IGSGERGLKDGSFAEASFNEPQGLALLpGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 340 DVVIGTSgsegqrDDILWIAMAGTHQIWALLLDCGrlpkkselkkgTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLAs 419
Cdd:cd14951    81 DVAWGPE------DDILYIAMAGTHQIWAYDLDTG-----------TCRVFAGSGNEGNRNGPYPHEAWFAQPSGLSLA- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 420 edPWSCLFVADSESSTVRTVSLKDGAVKHLIGGERDPTNLFAFGDIDGVGINAKLQHPLGVTWDKKrNLLYVADSYNHKI 499
Cdd:cd14951   143 --GWGELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPD-GSVYVADTYNHKI 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 500 KVVDPKTKSCTTLAGTGDAsnviGSSFTESTFNEPGGLCIGENGqLLYVADTNNHQIKVMDLETKTISVLPVFmseNATV 579
Cdd:cd14951   220 KRVDPATGEVSTLAGTGKA----GYKDLEAQFSEPSGLVVDGDG-RLYVADTNNHRIRRLDLPTEALEVLTLA---HRTL 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1910408677 580 DGPFLVEKQKTVPILPKSAPAIRLPPVAASPGQTLQFKLRL 620
Cdd:cd14951   292 RPATPPAPGPLRLRVRFTAPAGQKLDDRWGPSTRLKLSISP 332
TlpA_like_DipZ_like cd03012
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a ...
 55-182 3.59e-73

TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.


:

Pssm-ID: 239310 [Multi-domain]  Cd Length: 126  Bit Score: 232.97  E-value: 3.59e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  55 PEFPEGLEWLNTEEPISVYKnLCGKVVILDFFTYCCINCIHLLPDLHALEDTYSDkDGLLIVGVHSAKFPNEKVLDNIKS 134
Cdd:cd03012     1 PEFEGILQWLNTDKPLSLAQ-LRGKVVLLDFWTYCCINCLHTLPYLTDLEQKYKD-DGLVVIGVHSPEFAFERDLANVKS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1910408677 135 AVLRYNITHPVVNDADASLWQELEVSCWPTLVIFGPRGNMLFSLIGEG 182
Cdd:cd03012    79 AVLRYGITYPVANDNDYATWRAYGNQYWPALYLIDPTGNVRHVHFGEG 126
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 165-301 5.97e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14954:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 285  Bit Score: 54.86  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 165 LVIFGPRGNMLFSLIGEGhkdklflytsialkyyKDRGQirdnkigiklykdslppspLLFPGKVTVDHVSkRLVIADTG 244
Cdd:cd14954   188 LQVFDPDGQFLRFFGSEG----------------SGNGQ-------------------FKRPRGVAVDDEG-NIIVADSG 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1910408677 245 HHRILVIWKNGQIQYSIGGPNPGrkdgifsESTFNSPQGVAIMNN-IIYVADTENHLI 301
Cdd:cd14954   232 NHRVQVFSPDGEFLCSFGTEGNG-------EGQFDRPSGVAVTPDgRIVVVDRGNHRI 282
 
Name Accession Description Interval E-value
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 261-620 0e+00

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 551.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 261 IGGPNPGRKDGIFSESTFNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEMVSTVAGIGIQGSDKEGGAQGEEQPISSPW 339
Cdd:cd14951     1 IGSGERGLKDGSFAEASFNEPQGLALLpGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 340 DVVIGTSgsegqrDDILWIAMAGTHQIWALLLDCGrlpkkselkkgTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLAs 419
Cdd:cd14951    81 DVAWGPE------DDILYIAMAGTHQIWAYDLDTG-----------TCRVFAGSGNEGNRNGPYPHEAWFAQPSGLSLA- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 420 edPWSCLFVADSESSTVRTVSLKDGAVKHLIGGERDPTNLFAFGDIDGVGINAKLQHPLGVTWDKKrNLLYVADSYNHKI 499
Cdd:cd14951   143 --GWGELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPD-GSVYVADTYNHKI 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 500 KVVDPKTKSCTTLAGTGDAsnviGSSFTESTFNEPGGLCIGENGqLLYVADTNNHQIKVMDLETKTISVLPVFmseNATV 579
Cdd:cd14951   220 KRVDPATGEVSTLAGTGKA----GYKDLEAQFSEPSGLVVDGDG-RLYVADTNNHRIRRLDLPTEALEVLTLA---HRTL 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1910408677 580 DGPFLVEKQKTVPILPKSAPAIRLPPVAASPGQTLQFKLRL 620
Cdd:cd14951   292 RPATPPAPGPLRLRVRFTAPAGQKLDDRWGPSTRLKLSISP 332
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 30-723 0e+00

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 545.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677   30 TQEEKNNLVYQYLQKVDGWEQD---LLVPEFPEGLEWLNTEePISVYKNLCGKVVILDFFTYCCINCIHLLPDLHALEDT 106
Cdd:PLN02919   370 AQNSGEGCVQQFVSYISDLESKktaTKVPEFPPKLDWLNTA-PLQFRRDLKGKVVILDFWTYCCINCMHVLPDLEFLEKK 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  107 YSDKDgLLIVGVHSAKFPNEKVLDNIKSAVLRYNITHPVVNDADASLWQELEVSCWPTLVIFGPRGNMLFSLIGEGHKDK 186
Cdd:PLN02919   449 YKDQP-FTVVGVHSAKFDNEKDLEAIRNAVLRYNISHPVVNDGDMYLWRELGVSSWPTFAVVSPNGKLIAQLSGEGHRKD 527

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  187 LFLYTSIALKYYKDRGQIRDNKIGIKLYKDSLP---PSPLLFPGKVTVDHVSKRLVIADTGHHRILVIWKNGQIQYSIGG 263
Cdd:PLN02919   528 LDDLVEAALQYYGEKKLLDSTPLPLSLEKDNDPrllTSPLKFPGKLAIDLLNNRLFISDSNHNRIVVTDLDGNFIVQIGS 607

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  264 PN-PGRKDGIFSESTFNSPQGVA--IMNNIIYVADTENHLIRKIDLEAEMVSTVAGIGIQGSDKEGGAQGEEQPISSPWD 340
Cdd:PLN02919   608 TGeEGLRDGSFEDATFNRPQGLAynAKKNLLYVADTENHALREIDFVNETVRTLAGNGTKGSDYQGGKKGTSQVLNSPWD 687

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  341 VVIGTSgsegqrDDILWIAMAGTHQIWallldcgrlpkKSELKKGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLASE 420
Cdd:PLN02919   688 VCFEPV------NEKVYIAMAGQHQIW-----------EYNISDGVTRVFSGDGYERNLNGSSGTSTSFAQPSGISLSPD 750

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  421 dpWSCLFVADSESSTVRTVSLKDGAVKHLIGGerDPT---NLFAFGDIDGVGINAKLQHPLGVTWDKKrNLLYVADSYNH 497
Cdd:PLN02919   751 --LKELYIADSESSSIRALDLKTGGSRLLAGG--DPTfsdNLFKFGDHDGVGSEVLLQHPLGVLCAKD-GQIYVADSYNH 825

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  498 KIKVVDPKTKSCTTLAGTGDASNVIGSSFtESTFNEPGGLCIGENGQlLYVADTNNHQIKVMDLETKTISVLPVFmsENA 577
Cdd:PLN02919   826 KIKKLDPATKRVTTLAGTGKAGFKDGKAL-KAQLSEPAGLALGENGR-LFVADTNNSLIRYLDLNKGEAAEILTL--ELK 901

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  578 TVDGPflVEKQKTVPILPKSAPA----IRLPPVAASPGqtlQFKLRLDFPSGTKLTEGAPSCWfltakgnewllqgqips 653
Cdd:PLN02919   902 GVQPP--RPKSKSLKRLRRRSSAdtqvIKVDGVTSLEG---DLQLKISLPPGYHFSKEARSKF----------------- 959

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  654 geieSISSQPTIQLQI-PAD-CLSPE--AVIS------------ISVLLYYCSMDgSACMMKGISFSQPLQITHAQGCTA 717
Cdd:PLN02919   960 ----EVEVEPENAVDIdPDEgTLSPDgrASLHfkrssasastgrISCKVYYCKED-EVCLYQSLVFEVPFEEENGGESSS 1034


                   ....*.
gi 1910408677  718 PVELKY 723
Cdd:PLN02919  1035 SITLKY 1040
TlpA_like_DipZ_like cd03012
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a ...
 55-182 3.59e-73

TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.


Pssm-ID: 239310 [Multi-domain]  Cd Length: 126  Bit Score: 232.97  E-value: 3.59e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  55 PEFPEGLEWLNTEEPISVYKnLCGKVVILDFFTYCCINCIHLLPDLHALEDTYSDkDGLLIVGVHSAKFPNEKVLDNIKS 134
Cdd:cd03012     1 PEFEGILQWLNTDKPLSLAQ-LRGKVVLLDFWTYCCINCLHTLPYLTDLEQKYKD-DGLVVIGVHSPEFAFERDLANVKS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1910408677 135 AVLRYNITHPVVNDADASLWQELEVSCWPTLVIFGPRGNMLFSLIGEG 182
Cdd:cd03012    79 AVLRYGITYPVANDNDYATWRAYGNQYWPALYLIDPTGNVRHVHFGEG 126
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 78-187 7.52e-22

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 92.06  E-value: 7.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  78 GKVVILDFFTYCCINCIHLLPDLHALEDTYsdkDGLLIVGVHSAKFPnekvlDNIKSAVLRYNITHPVVNDADASLWQEL 157
Cdd:COG0526    28 GKPVLVNFWATWCPPCRAEMPVLKELAEEY---GGVVFVGVDVDENP-----EAVKAFLKELGLPYPVLLDPDGELAKAY 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1910408677 158 EVSCWPTLVIFGPRGNMLFSLIGEGHKDKL 187
Cdd:COG0526   100 GVRGIPTTVLIDKDGKIVARHVGPLSPEEL 129
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
220-570 3.20e-20

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 91.23  E-value: 3.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 220 PSPLLFPGKVTVDHvSKRLVIADTGHHRILVIwkngqiqysiggpNPgrKDGIFSE---STFNSPQGVAI-MNNIIYVAD 295
Cdd:COG4257    13 PAPGSGPRDVAVDP-DGAVWFTDQGGGRIGRL-------------DP--ATGEFTEyplGGGSGPHGIAVdPDGNLWFTD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 296 TENHLIRKIDLEAEMVSTVAGIGiqgsdkeggaqgeeqPISSPWDVVIGtsgsegqRDDILWIAMAGTHQIwallldcGR 375
Cdd:COG4257    77 NGNNRIGRIDPKTGEITTFALPG---------------GGSNPHGIAFD-------PDGNLWFTDQGGNRI-------GR 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 376 L-PKKSELKkgtclrfagsgneenrnnAYPHKAGFAQPSGLSLASED-PWsclfVADSESSTVRTVSLKDGAVKHLIGge 453
Cdd:COG4257   128 LdPATGEVT------------------EFPLPTGGAGPYGIAVDPDGnLW----VTDFGANAIGRIDPDTGTLTEYAL-- 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 454 rdPTnlfafgdidgvginaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGTGDASnvigssftestfnE 533
Cdd:COG4257   184 --PT---------------PGAGPRGLAVDPDGNL-WVADTGSGRIGRFDPKTGTVTEYPLPGGGA-------------R 232

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1910408677 534 PGGLCIGENGQlLYVADTNNHQIKVMDLETKTIS-VLP 570
Cdd:COG4257   233 PYGVAVDGDGR-VWFAESGANRIVRFDPDTELTEyVLP 269
Thioredoxin_8 pfam13905
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the ...
 78-173 5.94e-18

Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.


Pssm-ID: 464033 [Multi-domain]  Cd Length: 95  Bit Score: 79.27  E-value: 5.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  78 GKVVILDFFTYCCINCIHLLPDLHALEDTYSDKDGLLIVGVHSAKFPNEkvLDNIKSAVLRYNITHPVVNDADASLWQEL 157
Cdd:pfam13905   1 GKVVLLYFGASWCKPCRRFTPLLKELYEKLKKKKNVEIVFVSLDRDLEE--FKDYLKKMPKDWLSVPFDDDERNELKRKY 78

                          90
                  ....*....|....*.
gi 1910408677 158 EVSCWPTLVIFGPRGN 173
Cdd:pfam13905  79 GVNAIPTLVLLDPNGE 94
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 165-301 5.97e-08

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 54.86  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 165 LVIFGPRGNMLFSLIGEGhkdklflytsialkyyKDRGQirdnkigiklykdslppspLLFPGKVTVDHVSkRLVIADTG 244
Cdd:cd14954   188 LQVFDPDGQFLRFFGSEG----------------SGNGQ-------------------FKRPRGVAVDDEG-NIIVADSG 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1910408677 245 HHRILVIWKNGQIQYSIGGPNPGrkdgifsESTFNSPQGVAIMNN-IIYVADTENHLI 301
Cdd:cd14954   232 NHRVQVFSPDGEFLCSFGTEGNG-------EGQFDRPSGVAVTPDgRIVVVDRGNHRI 282
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 531-558 9.18e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 39.69  E-value: 9.18e-05
                          10        20
                  ....*....|....*....|....*...
gi 1910408677 531 FNEPGGLCIGENGQLlYVADTNNHQIKV 558
Cdd:pfam01436   1 FNRPHGVAVDSNGDI-YVADSENHRVQV 27
 
Name Accession Description Interval E-value
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 261-620 0e+00

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 551.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 261 IGGPNPGRKDGIFSESTFNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEMVSTVAGIGIQGSDKEGGAQGEEQPISSPW 339
Cdd:cd14951     1 IGSGERGLKDGSFAEASFNEPQGLALLpGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 340 DVVIGTSgsegqrDDILWIAMAGTHQIWALLLDCGrlpkkselkkgTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLAs 419
Cdd:cd14951    81 DVAWGPE------DDILYIAMAGTHQIWAYDLDTG-----------TCRVFAGSGNEGNRNGPYPHEAWFAQPSGLSLA- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 420 edPWSCLFVADSESSTVRTVSLKDGAVKHLIGGERDPTNLFAFGDIDGVGINAKLQHPLGVTWDKKrNLLYVADSYNHKI 499
Cdd:cd14951   143 --GWGELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPD-GSVYVADTYNHKI 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 500 KVVDPKTKSCTTLAGTGDAsnviGSSFTESTFNEPGGLCIGENGqLLYVADTNNHQIKVMDLETKTISVLPVFmseNATV 579
Cdd:cd14951   220 KRVDPATGEVSTLAGTGKA----GYKDLEAQFSEPSGLVVDGDG-RLYVADTNNHRIRRLDLPTEALEVLTLA---HRTL 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1910408677 580 DGPFLVEKQKTVPILPKSAPAIRLPPVAASPGQTLQFKLRL 620
Cdd:cd14951   292 RPATPPAPGPLRLRVRFTAPAGQKLDDRWGPSTRLKLSISP 332
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 30-723 0e+00

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 545.22  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677   30 TQEEKNNLVYQYLQKVDGWEQD---LLVPEFPEGLEWLNTEePISVYKNLCGKVVILDFFTYCCINCIHLLPDLHALEDT 106
Cdd:PLN02919   370 AQNSGEGCVQQFVSYISDLESKktaTKVPEFPPKLDWLNTA-PLQFRRDLKGKVVILDFWTYCCINCMHVLPDLEFLEKK 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  107 YSDKDgLLIVGVHSAKFPNEKVLDNIKSAVLRYNITHPVVNDADASLWQELEVSCWPTLVIFGPRGNMLFSLIGEGHKDK 186
Cdd:PLN02919   449 YKDQP-FTVVGVHSAKFDNEKDLEAIRNAVLRYNISHPVVNDGDMYLWRELGVSSWPTFAVVSPNGKLIAQLSGEGHRKD 527

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  187 LFLYTSIALKYYKDRGQIRDNKIGIKLYKDSLP---PSPLLFPGKVTVDHVSKRLVIADTGHHRILVIWKNGQIQYSIGG 263
Cdd:PLN02919   528 LDDLVEAALQYYGEKKLLDSTPLPLSLEKDNDPrllTSPLKFPGKLAIDLLNNRLFISDSNHNRIVVTDLDGNFIVQIGS 607

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  264 PN-PGRKDGIFSESTFNSPQGVA--IMNNIIYVADTENHLIRKIDLEAEMVSTVAGIGIQGSDKEGGAQGEEQPISSPWD 340
Cdd:PLN02919   608 TGeEGLRDGSFEDATFNRPQGLAynAKKNLLYVADTENHALREIDFVNETVRTLAGNGTKGSDYQGGKKGTSQVLNSPWD 687

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  341 VVIGTSgsegqrDDILWIAMAGTHQIWallldcgrlpkKSELKKGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLASE 420
Cdd:PLN02919   688 VCFEPV------NEKVYIAMAGQHQIW-----------EYNISDGVTRVFSGDGYERNLNGSSGTSTSFAQPSGISLSPD 750

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  421 dpWSCLFVADSESSTVRTVSLKDGAVKHLIGGerDPT---NLFAFGDIDGVGINAKLQHPLGVTWDKKrNLLYVADSYNH 497
Cdd:PLN02919   751 --LKELYIADSESSSIRALDLKTGGSRLLAGG--DPTfsdNLFKFGDHDGVGSEVLLQHPLGVLCAKD-GQIYVADSYNH 825

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  498 KIKVVDPKTKSCTTLAGTGDASNVIGSSFtESTFNEPGGLCIGENGQlLYVADTNNHQIKVMDLETKTISVLPVFmsENA 577
Cdd:PLN02919   826 KIKKLDPATKRVTTLAGTGKAGFKDGKAL-KAQLSEPAGLALGENGR-LFVADTNNSLIRYLDLNKGEAAEILTL--ELK 901

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  578 TVDGPflVEKQKTVPILPKSAPA----IRLPPVAASPGqtlQFKLRLDFPSGTKLTEGAPSCWfltakgnewllqgqips 653
Cdd:PLN02919   902 GVQPP--RPKSKSLKRLRRRSSAdtqvIKVDGVTSLEG---DLQLKISLPPGYHFSKEARSKF----------------- 959

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  654 geieSISSQPTIQLQI-PAD-CLSPE--AVIS------------ISVLLYYCSMDgSACMMKGISFSQPLQITHAQGCTA 717
Cdd:PLN02919   960 ----EVEVEPENAVDIdPDEgTLSPDgrASLHfkrssasastgrISCKVYYCKED-EVCLYQSLVFEVPFEEENGGESSS 1034


                   ....*.
gi 1910408677  718 PVELKY 723
Cdd:PLN02919  1035 SITLKY 1040
TlpA_like_DipZ_like cd03012
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a ...
 55-182 3.59e-73

TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.


Pssm-ID: 239310 [Multi-domain]  Cd Length: 126  Bit Score: 232.97  E-value: 3.59e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  55 PEFPEGLEWLNTEEPISVYKnLCGKVVILDFFTYCCINCIHLLPDLHALEDTYSDkDGLLIVGVHSAKFPNEKVLDNIKS 134
Cdd:cd03012     1 PEFEGILQWLNTDKPLSLAQ-LRGKVVLLDFWTYCCINCLHTLPYLTDLEQKYKD-DGLVVIGVHSPEFAFERDLANVKS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1910408677 135 AVLRYNITHPVVNDADASLWQELEVSCWPTLVIFGPRGNMLFSLIGEG 182
Cdd:cd03012    79 AVLRYGITYPVANDNDYATWRAYGNQYWPALYLIDPTGNVRHVHFGEG 126
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 238-556 4.73e-48

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 172.33  E-value: 4.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 238 LVIADTGHHRILVIWKNGQIQYSIGGPNPGRKDGIFSESTFNSPQGVAI-MNNIIYVADTENHLIRKIDLeAEMVSTVAG 316
Cdd:cd14953    36 LYVADRGNHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNTPSGVAVdAAGNLYVADTGNHRIRKITP-DGVVSTLAG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 317 IGIQGSDKEGGAqgEEQPISSPWDVVIGTSGsegqrddILWIAMAGTHQIwallldcgrlpkkselKK----GTCLRFAG 392
Cdd:cd14953   115 TGTAGFSDDGGA--TAAQFNYPTGVAVDAAG-------NLYVADTGNHRI----------------RKitpdGVVTTVAG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 393 SGNEENRNNAYPHKAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLkDGAVKHLIGgerdptNLFAFGDIDGVGINA 472
Cdd:cd14953   170 TGGAGYAGDGPATAAQFNNPTGVAV---DAAGNLYVADRGNHRIRKITP-DGVVTTVAG------TGTAGFSGDGGATAA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 473 KLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGTGDASNVIGSSfTESTFNEPGGLCIGENGqLLYVADTN 552
Cdd:cd14953   240 QLNNPTGVAVDAAGNL-YVADSGNHRIRKITPAGVVTTVAGGGAGFSGDGGPA-TSAQFNNPTGVAVDAAG-NLYVADTG 316


                  ....
gi 1910408677 553 NHQI 556
Cdd:cd14953   317 NNRI 320
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 262-556 2.11e-44

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 162.31  E-value: 2.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 262 GGPNPGRKDGIFSESTFNSPQGVAI--MNNIiYVADTENHLIRKIDLEAEmVSTVAGIGIQGSDKEGGAQGEeqpISSPW 339
Cdd:cd14953     6 GSGTAGFSGGGGTAARFNSPSGVAVdaAGNL-YVADRGNHRIRKITPDGV-VTTVAGTGTAGFADGGGAAAQ---FNTPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 340 DVVIGTSGSegqrddiLWIAMAGTHQIwallldcgrlpkkselKK----GTCLRFAGSGNEENRNNAYPHKAGFAQPSGL 415
Cdd:cd14953    81 GVAVDAAGN-------LYVADTGNHRI----------------RKitpdGVVSTLAGTGTAGFSDDGGATAAQFNYPTGV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 416 SLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLIGGERdptnlfAFGDIDGVGINAKLQHPLGVTWDKKRNLlYVADSY 495
Cdd:cd14953   138 AV---DAAGNLYVADTGNHRIRKIT-PDGVVTTVAGTGG------AGYAGDGPATAAQFNNPTGVAVDAAGNL-YVADRG 206

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1910408677 496 NHKIKVVDPKTKsCTTLAGTGDASNVIGSSFTESTFNEPGGLCIGENGQlLYVADTNNHQI 556
Cdd:cd14953   207 NHRIRKITPDGV-VTTVAGTGTAGFSGDGGATAAQLNNPTGVAVDAAGN-LYVADSGNHRI 265
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 220-558 3.96e-39

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 145.54  E-value: 3.96e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 220 PSPLLFPGKVTVDHvSKRLVIADTGHHRILVIWKNGQIQYSIGGpnPGRKDGifsesTFNSPQGVAI-MNNIIYVADTEN 298
Cdd:cd05819     4 PGELNNPQGIAVDS-SGNIYVADTGNNRIQVFDPDGNFITSFGS--FGSGDG-----QFNEPAGVAVdSDGNLYVADTGN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 299 HLIRKIDLEAEmvsTVAGIGIQGSDKEGgaqgeeqpISSPWDVVIGTSGSegqrddiLWIAMAGTHQIWALLLDcgrlpk 378
Cdd:cd05819    76 HRIQKFDPDGN---FLASFGGSGDGDGE--------FNGPRGIAVDSSGN-------IYVADTGNHRIQKFDPD------ 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 379 kselkkGTCLRFAGSGNEENrnnayphkAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLKDGAVkhliggerdptn 458
Cdd:cd05819   132 ------GEFLTTFGSGGSGP--------GQFNGPTGVAV---DSDGNIYVADTGNHRIQVFDPDGNFL------------ 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 459 lFAFGDIdGVGiNAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTkscTTLAGTGDASNVIGSsftestFNEPGGLC 538
Cdd:cd05819   183 -TTFGST-GTG-PGQFNYPTGIAVDSDGN-IYVADSGNNRVQVFDPDG---AGFGGNGNFLGSDGQ------FNRPSGLA 249

                         330       340
                  ....*....|....*....|
gi 1910408677 539 IGENGQlLYVADTNNHQIKV 558
Cdd:cd05819   250 VDSDGN-LYVADTGNNRIQV 268
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 278-585 2.47e-38

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 143.61  E-value: 2.47e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 278 FNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEmvsTVAGIGIQGSDkeggaqgeEQPISSPWDVVIGTSGSegqrddiL 356
Cdd:cd05819     7 LNNPQGIAVDsSGNIYVADTGNNRIQVFDPDGN---FITSFGSFGSG--------DGQFNEPAGVAVDSDGN-------L 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 357 WIAMAGTHQIWALLLDcgrlpkkselkkGTCLR-FAGSGNEENrnnayphkaGFAQPSGLSLaseDPWSCLFVADSESST 435
Cdd:cd05819    69 YVADTGNHRIQKFDPD------------GNFLAsFGGSGDGDG---------EFNGPRGIAV---DSSGNIYVADTGNHR 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 436 VRTVSlKDGAVKHLIGGerdptnlfafgdidGVGINAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTkscTTLAGT 515
Cdd:cd05819   125 IQKFD-PDGEFLTTFGS--------------GGSGPGQFNGPTGVAVDSDGN-IYVADTGNHRIQVFDPDG---NFLTTF 185

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 516 GDASNVIGSsftestFNEPGGLCIGENGqLLYVADTNNHQIKVMDLETKTISVLPVFMSENATVDGPFLV 585
Cdd:cd05819   186 GSTGTGPGQ------FNYPTGIAVDSDG-NIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRPSGL 248
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 407-560 1.35e-26

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 111.08  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 407 AGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLIGGErdptnlfAFGDIDGVGINAKLQHPLGVTWDKKR 486
Cdd:cd14953    20 ARFNSPSGVAV---DAAGNLYVADRGNHRIRKIT-PDGVVTTVAGTG-------TAGFADGGGAAAQFNTPSGVAVDAAG 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1910408677 487 NLlYVADSYNHKIKVVDPKTKsCTTLAGTGDASNVIGSSFTESTFNEPGGLCIGENGQlLYVADTNNHQIKVMD 560
Cdd:cd14953    89 NL-YVADTGNHRIRKITPDGV-VSTLAGTGTAGFSDDGGATAAQFNYPTGVAVDAAGN-LYVADTGNHRIRKIT 159
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 223-439 4.29e-24

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 103.76  E-value: 4.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 223 LLFPGKVTVDHvSKRLVIADTGHHRILVIWKNGQIQYSIGGPNPGRK-DGIFSESTFNSPQGVAI-MNNIIYVADTENHL 300
Cdd:cd14953   131 FNYPTGVAVDA-AGNLYVADTGNHRIRKITPDGVVTTVAGTGGAGYAgDGPATAAQFNNPTGVAVdAAGNLYVADRGNHR 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 301 IRKIDLeAEMVSTVAGIGIQGSDKEGGAQgeEQPISSPWDVVIGTSGSegqrddiLWIAMAGTHQIwallldcgrlpkks 380
Cdd:cd14953   210 IRKITP-DGVVTTVAGTGTAGFSGDGGAT--AAQLNNPTGVAVDAAGN-------LYVADSGNHRI-------------- 265

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1910408677 381 eLK---KGTCLRFAGSGNEENRNNAYPHKAGFAQPSGLSLASEDPwscLFVADSESSTVRTV 439
Cdd:cd14953   266 -RKitpAGVVTTVAGGGAGFSGDGGPATSAQFNNPTGVAVDAAGN---LYVADTGNNRIRKI 323
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 78-180 7.37e-24

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 96.92  E-value: 7.37e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  78 GKVVILDFFTYCCINCIHLLPDLHALEDTYSDkDGLLIVGVHSAKFPNEKVldniKSAVLRYNITHPVVNDADASLWQEL 157
Cdd:cd02966    19 GKVVLVNFWASWCPPCRAEMPELEALAKEYKD-DGVEVVGVNVDDDDPAAV----KAFLKKYGITFPVLLDPDGELAKAY 93

                          90       100
                  ....*....|....*....|...
gi 1910408677 158 EVSCWPTLVIFGPRGNMLFSLIG 180
Cdd:cd02966    94 GVRGLPTTFLIDRDGRIRARHVG 116
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 166-437 1.16e-22

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 98.16  E-value: 1.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 166 VIFGPRGNMLFSLIGEGHKDKLFLY-TSIALK---------YYKDRGQI--RDNKIGIKLYKDSLPPSPLLFPGKVTVDH 233
Cdd:cd05819    32 QVFDPDGNFITSFGSFGSGDGQFNEpAGVAVDsdgnlyvadTGNHRIQKfdPDGNFLASFGGSGDGDGEFNGPRGIAVDS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 234 vSKRLVIADTGHHRILVIWKNGQIQYSIGGPNPGrkdgifsESTFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAEMVS 312
Cdd:cd05819   112 -SGNIYVADTGNHRIQKFDPDGEFLTTFGSGGSG-------PGQFNGPTGVAVdSDGNIYVADTGNHRIQVFDPDGNFLT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 313 TVagigiqGSDKEGGAQGeeqpiSSPWDVVIGTSGSegqrddiLWIAMAGTHQIwallldcgrlpkkselkkgtcLRFAG 392
Cdd:cd05819   184 TF------GSTGTGPGQF-----NYPTGIAVDSDGN-------IYVADSGNNRV---------------------QVFDP 224

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1910408677 393 SGNEENRN-NAYPHKAGFAQPSGLSLASEDpwsCLFVADSESSTVR 437
Cdd:cd05819   225 DGAGFGGNgNFLGSDGQFNRPSGLAVDSDG---NLYVADTGNNRIQ 267
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 78-187 7.52e-22

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 92.06  E-value: 7.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  78 GKVVILDFFTYCCINCIHLLPDLHALEDTYsdkDGLLIVGVHSAKFPnekvlDNIKSAVLRYNITHPVVNDADASLWQEL 157
Cdd:COG0526    28 GKPVLVNFWATWCPPCRAEMPVLKELAEEY---GGVVFVGVDVDENP-----EAVKAFLKELGLPYPVLLDPDGELAKAY 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1910408677 158 EVSCWPTLVIFGPRGNMLFSLIGEGHKDKL 187
Cdd:COG0526   100 GVRGIPTTVLIDKDGKIVARHVGPLSPEEL 129
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 225-558 2.30e-21

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 94.64  E-value: 2.30e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 225 FPGKVTVDhVSKRLVIADTGHHRILVIWKNGQIQYSIGgpNPGRKDGIFsestfNSPQGVAI-MNNIIYVADTENHLIRK 303
Cdd:cd14957    19 TPRGIAVD-SAGNIYVADTGNNRIQVFTSSGVYSYSIG--SGGTGSGQF-----NSPYGIAVdSNGNIYVADTDNNRIQV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 304 IDLEAEMVSTvagIGIQGSdkeGGAQGEEqpissPWDVVIGTSGSegqrddiLWIAMAGTH--QIWAllldcgrlpkkse 381
Cdd:cd14957    91 FNSSGVYQYS---IGTGGS---GDGQFNG-----PYGIAVDSNGN-------IYVADTGNHriQVFT------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 382 lKKGTCLRFAGSGNEENRNnayphkagFAQPSGLSLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLIGGERDPTNLFa 461
Cdd:cd14957   140 -SSGTFSYSIGSGGTGPGQ--------FNGPQGIAV---DSDGNIYVADTGNHRIQVFT-SSGTFQYTFGSSGSGPGQF- 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 462 fgdidgvginaklQHPLGVTWDKKRNLlYVADSYNHKIKVVDPktkscttlAGTGDASnvIGSSFT-ESTFNEPGGLCIG 540
Cdd:cd14957   206 -------------SDPYGIAVDSDGNI-YVADTGNHRIQVFTS--------SGAYQYS--IGTSGSgNGQFNYPYGIAVD 261

                         330
                  ....*....|....*...
gi 1910408677 541 ENGQLlYVADTNNHQIKV 558
Cdd:cd14957   262 NDGKI-YVADSNNNRIQV 278
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
220-570 3.20e-20

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 91.23  E-value: 3.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 220 PSPLLFPGKVTVDHvSKRLVIADTGHHRILVIwkngqiqysiggpNPgrKDGIFSE---STFNSPQGVAI-MNNIIYVAD 295
Cdd:COG4257    13 PAPGSGPRDVAVDP-DGAVWFTDQGGGRIGRL-------------DP--ATGEFTEyplGGGSGPHGIAVdPDGNLWFTD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 296 TENHLIRKIDLEAEMVSTVAGIGiqgsdkeggaqgeeqPISSPWDVVIGtsgsegqRDDILWIAMAGTHQIwallldcGR 375
Cdd:COG4257    77 NGNNRIGRIDPKTGEITTFALPG---------------GGSNPHGIAFD-------PDGNLWFTDQGGNRI-------GR 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 376 L-PKKSELKkgtclrfagsgneenrnnAYPHKAGFAQPSGLSLASED-PWsclfVADSESSTVRTVSLKDGAVKHLIGge 453
Cdd:COG4257   128 LdPATGEVT------------------EFPLPTGGAGPYGIAVDPDGnLW----VTDFGANAIGRIDPDTGTLTEYAL-- 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 454 rdPTnlfafgdidgvginaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGTGDASnvigssftestfnE 533
Cdd:COG4257   184 --PT---------------PGAGPRGLAVDPDGNL-WVADTGSGRIGRFDPKTGTVTEYPLPGGGA-------------R 232

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1910408677 534 PGGLCIGENGQlLYVADTNNHQIKVMDLETKTIS-VLP 570
Cdd:COG4257   233 PYGVAVDGDGR-VWFAESGANRIVRFDPDTELTEyVLP 269
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 226-558 1.05e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 89.65  E-value: 1.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 226 PGKVTVDHVSKRLViADTGHHRILVIWKNGQIQYSIGGPNPGRkdgifseSTFNSPQGVAIMNN-IIYVADTENHLIRKI 304
Cdd:cd14956    15 PRGIAVDADDNVYV-ADARNGRIQVFDKDGTFLRRFGTTGDGP-------GQFGRPRGLAVDKDgWLYVADYWGDRIQVF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 305 DLEAEMVSTvagIGIQGSdKEGGAQGeeqpissPWDVVIGTSGSegqrddiLWIAMAGTHQIWALLLDcgrlpkkselkk 384
Cdd:cd14956    87 TLTGELQTI---GGSSGS-GPGQFNA-------PRGVAVDADGN-------LYVADFGNQRIQKFDPD------------ 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 385 GTCLRFAGSgneenrnnaYPHKAG-FAQPSGLSLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLIGGErdptnlFAFg 463
Cdd:cd14956   137 GSFLRQWGG---------TGIEPGsFNYPRGVAV---DPDGTLYVADTYNDRIQVFD-NDGAFLRKWGGR------GTG- 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 464 didgvgiNAKLQHPLGVTWDKKRNLlYVADSYNHKIKVVdpkTKSCTTLAGTGDASNVIGssftesTFNEPGGLCIGENG 543
Cdd:cd14956   197 -------PGQFNYPYGIAIDPDGNV-FVADFGNNRIQKF---TADGTFLTSWGSPGTGPG------QFKNPWGVVVDADG 259

                         330
                  ....*....|....*
gi 1910408677 544 qLLYVADTNNHQIKV 558
Cdd:cd14956   260 -TVYVADSNNNRVQR 273
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 222-558 2.33e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 85.81  E-value: 2.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 222 PLLFPGKVTVDhvSKRLVIADTGHHRILVIWKNGQIQYSIGGpnPGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHL 300
Cdd:cd14963     8 PLNKPMGVAVS--DGRIYVADTNNHRVQVFDYEGKFKKSFGG--PGTGPG-----EFKYPYGIAVdSDGNIYVADLYNGR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 301 IRKIDLEAEMVSTVAgigiQGSDKEGgaqgeeqpISSPWDVVIgtsgsegqRDDILWIAMAGTHQIWALLLDcGRLPKKs 380
Cdd:cd14963    79 IQVFDPDGKFLKYFP----EKKDRVK--------LISPAGLAI--------DDGKLYVSDVKKHKVIVFDLE-GKLLLE- 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 381 elkkgtclrFAGSGNEENRnnayphkagFAQPSGLSLaseDPWSCLFVADSESSTVRTVSlKDGAVKHLIGGERDPTNLF 460
Cdd:cd14963   137 ---------FGKPGSEPGE---------LSYPNGIAV---DEDGNIYVADSGNGRIQVFD-KNGKFIKELNGSPDGKSGF 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 461 AfgdidgvginaklqHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTKSCTTLAGTGDASNvigssftesTFNEPGGLCIG 540
Cdd:cd14963   195 V--------------NPRGIAVDPDGN-LYVVDNLSHRVYVFDEQGKELFTFGGRGKDDG---------QFNLPNGLFID 250

                         330
                  ....*....|....*...
gi 1910408677 541 ENGQlLYVADTNNHQIKV 558
Cdd:cd14963   251 DDGR-LYVTDRENNRVAV 267
Thioredoxin_8 pfam13905
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the ...
 78-173 5.94e-18

Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.


Pssm-ID: 464033 [Multi-domain]  Cd Length: 95  Bit Score: 79.27  E-value: 5.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  78 GKVVILDFFTYCCINCIHLLPDLHALEDTYSDKDGLLIVGVHSAKFPNEkvLDNIKSAVLRYNITHPVVNDADASLWQEL 157
Cdd:pfam13905   1 GKVVLLYFGASWCKPCRRFTPLLKELYEKLKKKKNVEIVFVSLDRDLEE--FKDYLKKMPKDWLSVPFDDDERNELKRKY 78

                          90
                  ....*....|....*.
gi 1910408677 158 EVSCWPTLVIFGPRGN 173
Cdd:pfam13905  79 GVNAIPTLVLLDPNGE 94
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 278-569 4.82e-16

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 78.87  E-value: 4.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 278 FNSPQGVAIMNNIIYVADTENHLIRKIDLEAEMVSTVAGigiqgsdkEGGAQGEeqpISSPWDVVIGtsgSEGQrddiLW 357
Cdd:cd14963     9 LNKPMGVAVSDGRIYVADTNNHRVQVFDYEGKFKKSFGG--------PGTGPGE---FKYPYGIAVD---SDGN----IY 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 358 IAMAGThqiwallldcGRLPKKSelKKGTCLRFAGSGneENRNNAyphkagfAQPSGLSLASEDpwscLFVADSESSTVR 437
Cdd:cd14963    71 VADLYN----------GRIQVFD--PDGKFLKYFPEK--KDRVKL-------ISPAGLAIDDGK----LYVSDVKKHKVI 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 438 TVSLKdGAVKHLIGGErdptnlfafGDIDGvginaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGTGD 517
Cdd:cd14963   126 VFDLE-GKLLLEFGKP---------GSEPG-----ELSYPNGIAVDEDGNI-YVADSGNGRIQVFDKNGKFIKELNGSPD 189

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1910408677 518 ASnvigssfteSTFNEPGGLCIGENGQlLYVADTNNHQIKVMDLETKTISVL 569
Cdd:cd14963   190 GK---------SGFVNPRGIAVDPDGN-LYVVDNLSHRVYVFDEQGKELFTF 231
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 260-583 3.96e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 70.39  E-value: 3.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 260 SIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAEMVSTVAGIGiqgsdkeGGAQGEEQPissp 338
Cdd:cd14956     1 SWGGR--GSGPG-----QFKDPRGIAVdADDNVYVADARNGRIQVFDKDGTFLRRFGTTG-------DGPGQFGRP---- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 339 wdvvigtSGSEGQRDDILWIAMAGTHQIwallldcgrlpkkselkkgtcLRFAGSGNEENRNNAYPHKAG-FAQPSGlsl 417
Cdd:cd14956    63 -------RGLAVDKDGWLYVADYWGDRI---------------------QVFTLTGELQTIGGSSGSGPGqFNAPRG--- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 418 ASEDPWSCLFVADSESSTVRTVSLkDGAVkhliggerdptnLFAFG--DIDGVGINAklqhPLGVTWDKKRNLlYVADSY 495
Cdd:cd14956   112 VAVDADGNLYVADFGNQRIQKFDP-DGSF------------LRQWGgtGIEPGSFNY----PRGVAVDPDGTL-YVADTY 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 496 NHKIKVVDPktkscttlagTGDASNVIGSSFTES-TFNEPGGLCIGENGQlLYVADTNNHQIKVMdleTKTISVLPVFMS 574
Cdd:cd14956   174 NDRIQVFDN----------DGAFLRKWGGRGTGPgQFNYPYGIAIDPDGN-VFVADFGNNRIQKF---TADGTFLTSWGS 239


                  ....*....
gi 1910408677 575 ENaTVDGPF 583
Cdd:cd14956   240 PG-TGPGQF 247
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
278-571 1.24e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.89  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 278 FNSPQGVAIM-NNIIYVADTENHLIRKIDLEAEMVSTVAgigiqgsdkeggaqgeEQPISSPWDVVIGTSGSegqrddiL 356
Cdd:COG4257    16 GSGPRDVAVDpDGAVWFTDQGGGRIGRLDPATGEFTEYP----------------LGGGSGPHGIAVDPDGN-------L 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 357 WIAMAGTHQIWallldcgRLPKKSelkkGTCLRFAGSGNEenrnnAYPHKAGFAqPSGLslasedpwscLFVADSESSTV 436
Cdd:COG4257    73 WFTDNGNNRIG-------RIDPKT----GEITTFALPGGG-----SNPHGIAFD-PDGN----------LWFTDQGGNRI 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 437 RTVSLKDGAVKhliggerdptnLFAFGDIDGVginaklqhPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGtg 516
Cdd:COG4257   126 GRLDPATGEVT-----------EFPLPTGGAG--------PYGIAVDPDGNL-WVTDFGANAIGRIDPDTGTLTEYAL-- 183

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1910408677 517 dasnvigssftESTFNEPGGLCIGENGQLlYVADTNNHQIKVMDLETKTISVLPV 571
Cdd:COG4257   184 -----------PTPGAGPRGLAVDPDGNL-WVADTGSGRIGRFDPKTGTVTEYPL 226
Bcp COG1225
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];
76-181 3.29e-12

Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440838 [Multi-domain]  Cd Length: 136  Bit Score: 64.12  E-value: 3.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  76 LCGKVVILDFFTYCCINCIHLLPDLHALEDTYSDKdGLLIVGVHSAKfpnekvLDNIKSAVLRYNITHPVVNDADASLWQ 155
Cdd:COG1225    19 LRGKPVVLYFYATWCPGCTAELPELRDLYEEFKDK-GVEVLGVSSDS------DEAHKKFAEKYGLPFPLLSDPDGEVAK 91

                          90       100
                  ....*....|....*....|....*.
gi 1910408677 156 ELEVSCWPTLVIFGPRGNMLFSLIGE 181
Cdd:COG1225    92 AYGVRGTPTTFLIDPDGKIRYVWVGP 117
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 240-556 2.01e-11

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 65.29  E-value: 2.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 240 IADTGHHRILVIWKNGQIQYSIGGPNPGrkDGifsesTFNSPQGVAI--MNNIiYVADTENHLIRKIDleaemvST---V 314
Cdd:cd14955    31 VADTGNNRIQKFDSTGTFLTKWGSSGSG--DG-----QFYSPTGIAVdsDGNV-YVADTGNHRIQKFD------STgtfL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 315 AGIGIQGSdkeggaqGEEQpISSPWDVVIGTSGSegqrddiLWIAMAGTHQIW------ALLLDCGRLpkkselkkgtcl 388
Cdd:cd14955    97 TKWGSSGS-------GDGQ-FNSPSGIAVDSAGN-------VYVTDSGNNRIQkfdssgTFITKWGSF------------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 389 rfaGSGNEEnrnnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRTVSlkdgavkhliggeRDPTNLFAFGdIDGV 468
Cdd:cd14955   150 ---GSGDGQ-----------FNSPTGIAVDSAGN---VYVADTGNNRIQKFT-------------STGTFLTKWG-SEGS 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 469 GiNAKLQHPLGVTWDKKRNlLYVADSYNHKIKVVDPKTKSCTTLAGTGDAsnvigssftESTFNEPGGLCIGENGQlLYV 548
Cdd:cd14955   199 G-DGQFNAPYGIAVDSAGN-VYVADTGNNRIQKFDSSGTFITKWGSEGSG---------DGQFNSPSGIAVDSAGN-VYV 266


                  ....*...
gi 1910408677 549 ADTNNHQI 556
Cdd:cd14955   267 ADSGNNRI 274
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
426-571 3.00e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 3.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 426 LFVADSESSTVRTVSLKDGAVKHLIGgerdptnlfafgdidgVGinaklQHPLGVTWDKKRNLLYVADSYNHKIKVVDPK 505
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIP----------------VG-----GGPRGLAVDPDGGRLYVADSGNGRVSVIDTA 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1910408677 506 TKSCTTLAGTGdasnvigssftestfNEPGGLCIGENGQLLYVADTNNHQI----KVMDLET-KTISVLPV 571
Cdd:COG3391   141 TGKVVATIPVG---------------AGPHGIAVDPDGKRLYVANSGSNTVsvivSVIDTATgKVVATIPV 196
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 165-436 4.56e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 63.85  E-value: 4.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 165 LVIFGPRGNMLFSLIGEGHKDKLFLY-TSIALK---------YYKDRGQIRDNKiGIklYKDSLPPSP----LLFPGKVT 230
Cdd:cd14963    32 VQVFDYEGKFKKSFGGPGTGPGEFKYpYGIAVDsdgniyvadLYNGRIQVFDPD-GK--FLKYFPEKKdrvkLISPAGLA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 231 VDhvSKRLVIADTGHHRILVIWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAIM-NNIIYVADTENHLIRKIDLEAE 309
Cdd:cd14963   109 ID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKP--GSEPG-----ELSYPNGIAVDeDGNIYVADSGNGRIQVFDKNGK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 310 MVSTVAGigiqgsdKEGGAQGeeqpISSPWDVVIGtsgsegqRDDILWIAMAGTHQIWALlldcgrlpkkseLKKGTCLR 389
Cdd:cd14963   180 FIKELNG-------SPDGKSG----FVNPRGIAVD-------PDGNLYVVDNLSHRVYVF------------DEQGKELF 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1910408677 390 -FAGSGNEENRNNAyphkagfaqPSGLSLaseDPWSCLFVADSESSTV 436
Cdd:cd14963   230 tFGGRGKDDGQFNL---------PNGLFI---DDDGRLYVTDRENNRV 265
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 406-570 4.76e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 64.15  E-value: 4.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 406 KAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLKDGAVkHLIGGERDptnlfafgdidgvginAKLQHPLGVTWDKK 485
Cdd:cd14962     8 KEALTRPYGVAA---DGRGRIYVADTGRGAVFVFDLPNGKV-FVIGNAGP----------------NRFVSPIGVAIDAN 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 486 RNLlYVADSYNHKIKVVDPKTKSCTTLAGTGDasnvigssftestFNEPGGLCIGENGQLLYVADTNNHQIKVMDLETKT 565
Cdd:cd14962    68 GNL-YVSDAELGKVFVFDRDGKFLRAIGAGAL-------------FKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL 133


                  ....*
gi 1910408677 566 ISVLP 570
Cdd:cd14962   134 LFDIG 138
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 237-502 1.66e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 62.30  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 237 RLVIADTGHHRILVIWKNGQIQYSIGGPNPGrkdgifsESTFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAEMVSTVA 315
Cdd:cd14956    72 WLYVADYWGDRIQVFTLTGELQTIGGSSGSG-------PGQFNAPRGVAVdADGNLYVADFGNQRIQKFDPDGSFLRQWG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 316 GIGIqgsdkeggaqgEEQPISSPWDVVIGTSGSegqrddiLWIAMAGTHQIWALLLDCGRLpkkseLKKGTclRFAGSGN 395
Cdd:cd14956   145 GTGI-----------EPGSFNYPRGVAVDPDGT-------LYVADTYNDRIQVFDNDGAFL-----RKWGG--RGTGPGQ 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 396 eenrnnayphkagFAQPSGLSLaseDPWSCLFVADSESSTVrTVSLKDGAVkhliggerdptnLFAFGDIDGVgiNAKLQ 475
Cdd:cd14956   200 -------------FNYPYGIAI---DPDGNVFVADFGNNRI-QKFTADGTF------------LTSWGSPGTG--PGQFK 248

                         250       260
                  ....*....|....*....|....*..
gi 1910408677 476 HPLGVTWDKkRNLLYVADSYNHKIKVV 502
Cdd:cd14956   249 NPWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 409-564 4.07e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 61.06  E-value: 4.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 409 FAQPSGLSLASEDPwscLFVADSESSTVrTVSLKDGAVKHLIGGErdptnlfafgdidgvginAKLQHPLGVTWDKKRNL 488
Cdd:cd14962    56 FVSPIGVAIDANGN---LYVSDAELGKV-FVFDRDGKFLRAIGAG------------------ALFKRPTGIAVDPAGKR 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1910408677 489 LYVADSYNHKIKVVDPKTKSCTTLAGTGDAsnvigssftESTFNEPGGLCIGENGQlLYVADTNNHQIKVMDLETK 564
Cdd:cd14962   114 LYVVDTLAHKVKVFDLDGRLLFDIGKRGSG---------PGEFNLPTDLAVDRDGN-LYVTDTMNFRVQIFDADGK 179
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 237-582 4.18e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 61.41  E-value: 4.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 237 RLVIADTGHHRILVIWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAemvstva 315
Cdd:cd14954    36 RIIVADRSNNRVQVFDPDGKFLRKFGSY--GSRDG-----QFDRPAGVAVnSRGRIIVADKDNHRIQVFDLNG------- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 316 gigiqgsdkeggaqgeeqpisspwdVVIGTSGSEGQRDdilwiamagthqiwallldcGRlpkkselkkgtclrfagsgn 395
Cdd:cd14954   102 -------------------------RFLLKFGERGTKN--------------------GQ-------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 396 eenrnnayphkagFAQPSGLSLASEDpwsCLFVADSESSTVRTVSLkDGAVKHLIGGErdptnlfafGDIDGvginaKLQ 475
Cdd:cd14954   117 -------------FNYPWGVAVDSEG---RIYVSDTRNHRVQVFDS-DGQFIRKFGFE---------GAGPG-----QLD 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 476 HPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGTGDAsnvigssftESTFNEPGGLCIGENGQLLyVADTNNHQ 555
Cdd:cd14954   166 SPRGVAVNPDGNI-VVSDFNNHRLQVFDPDGQFLRFFGSEGSG---------NGQFKRPRGVAVDDEGNII-VADSGNHR 234

                         330       340
                  ....*....|....*....|....*..
gi 1910408677 556 IKVMDLETKTISVLPVFMSENATVDGP 582
Cdd:cd14954   235 VQVFSPDGEFLCSFGTEGNGEGQFDRP 261
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 460-560 6.53e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 60.74  E-value: 6.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 460 FAFGDIdGVGINAkLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPktkscttlagTGDASNVIGSSFT-ESTFNEPGGLC 538
Cdd:cd14957     5 YAFGSN-GSGNGQ-FNTPRGIAVDSAGNI-YVADTGNNRIQVFTS----------SGVYSYSIGSGGTgSGQFNSPYGIA 71

                          90       100
                  ....*....|....*....|..
gi 1910408677 539 IGENGQlLYVADTNNHQIKVMD 560
Cdd:cd14957    72 VDSNGN-IYVADTDNNRIQVFN 92
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 225-558 6.60e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 60.64  E-value: 6.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 225 FPGKVTVDhVSKRLVIADTGHHRILVIWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHliRk 303
Cdd:cd14954    72 RPAGVAVN-SRGRIIVADKDNHRIQVFDLNGRFLLKFGER--GTKNG-----QFNYPWGVAVdSEGRIYVSDTRNH--R- 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 304 idleaemvstvagigIQGSDKEGgaqgeeqpisspwdVVIGTSGSEgqrddilwiamagthqiwallldcGRLPKKselk 383
Cdd:cd14954   141 ---------------VQVFDSDG--------------QFIRKFGFE------------------------GAGPGQ---- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 384 kgtclrfagsgneenrnnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRTVSLkDGAVKHLIGGErdptnlfafG 463
Cdd:cd14954   164 -------------------------LDSPRGVAVNPDGN---IVVSDFNNHRLQVFDP-DGQFLRFFGSE---------G 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 464 DIDGvginaKLQHPLGVTWDKKRNLLyVADSYNHKIKVVDPKTKSCTTLAGTGDAsnvigssftESTFNEPGGLCIGENG 543
Cdd:cd14954   206 SGNG-----QFKRPRGVAVDDEGNII-VADSGNHRVQVFSPDGEFLCSFGTEGNG---------EGQFDRPSGVAVTPDG 270

                         330
                  ....*....|....*
gi 1910408677 544 qLLYVADTNNHQIKV 558
Cdd:cd14954   271 -RIVVVDRGNHRIQV 284
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 216-558 1.16e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 59.91  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 216 DSLPPSPLLFPGKVTVDHvSKRLVIADTGHHRILVIWKNGQIQYSIGGPNPGRkdgifsestFNSPQGVAI-MNNIIYVA 294
Cdd:cd14962     4 EERPKEALTRPYGVAADG-RGRIYVADTGRGAVFVFDLPNGKVFVIGNAGPNR---------FVSPIGVAIdANGNLYVS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 295 DTENHLIRKIDLEAEMVSTVagigiqgsdkeggaqGEEQPISSPWDVVIGtsgSEGQRddiLWIAMAGTHQIWALLLDcG 374
Cdd:cd14962    74 DAELGKVFVFDRDGKFLRAI---------------GAGALFKRPTGIAVD---PAGKR---LYVVDTLAHKVKVFDLD-G 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 375 RLPKkselkkgtclRF--AGSGNEEnrnnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRTVSLKDGAVKHligg 452
Cdd:cd14962   132 RLLF----------DIgkRGSGPGE-----------FNLPTDLAVDRDGN---LYVTDTMNFRVQIFDADGKFLRS---- 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 453 erdptnlfaFGDI-DGVGinaKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGTGDASnvigssfteSTF 531
Cdd:cd14962   184 ---------FGERgDGPG---SFARPKGIAVDSEGNI-YVVDAAFDNVQIFNPEGELLLTVGGPGSGP---------GEF 241

                         330       340
                  ....*....|....*....|....*..
gi 1910408677 532 NEPGGLCIGENGQlLYVADTNNHQIKV 558
Cdd:cd14962   242 YLPSGIAIDKDDR-IYVVDQFNRRIQV 267
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 489-560 3.67e-09

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 58.43  E-value: 3.67e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910408677 489 LYVADSYNHKIKVVDpktkscttlaGTGDASNVIGSSFTEST-FNEPGGLCIGENGQlLYVADTNNHQIKVMD 560
Cdd:cd14957    78 IYVADTDNNRIQVFN----------SSGVYQYSIGTGGSGDGqFNGPYGIAVDSNGN-IYVADTGNHRIQVFT 139
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 225-436 6.10e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 57.68  E-value: 6.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 225 FPGKVTVDhVSKRLVIADTGHHRILVIWKNGQIQYSIGGPN--PGRkdgifsestFNSPQGVAIM-NNIIYVADTENHLI 301
Cdd:cd14956   108 APRGVAVD-ADGNLYVADFGNQRIQKFDPDGSFLRQWGGTGiePGS---------FNYPRGVAVDpDGTLYVADTYNDRI 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 302 RKIDLEAEMVSTVAGigiqgsdkEGGAQGEeqpISSPWDVVIGTSGSegqrddiLWIAMAGTHQIWALLLDcgrlpkkse 381
Cdd:cd14956   178 QVFDNDGAFLRKWGG--------RGTGPGQ---FNYPYGIAIDPDGN-------VFVADFGNNRIQKFTAD--------- 230

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1910408677 382 lkkGTCLRFAGSgneenrnnaYPHKAG-FAQPSGLSLASeDPWscLFVADSESSTV 436
Cdd:cd14956   231 ---GTFLTSWGS---------PGTGPGqFKNPWGVVVDA-DGT--VYVADSNNNRV 271
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
403-571 1.66e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 56.18  E-value: 1.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 403 YPHKAGFAQPSGLSLaseDPWSCLFVADSESSTVRTVSLKDGAVKhliggERDPtnlfafgdidgvginAKLQHPLGVTW 482
Cdd:COG4257    10 YPVPAPGSGPRDVAV---DPDGAVWFTDQGGGRIGRLDPATGEFT-----EYPL---------------GGGSGPHGIAV 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 483 DKkRNLLYVADSYNHKIKVVDPKTKSCTTLAGTGDASNvigssftestfnePGGLCIGENGQlLYVADTNNHQIKVMDLE 562
Cdd:COG4257    67 DP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSN-------------PHGIAFDPDGN-LWFTDQGGNRIGRLDPA 131


                  ....*....
gi 1910408677 563 TKTISVLPV 571
Cdd:COG4257   132 TGEVTEFPL 140
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 465-570 1.70e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 56.15  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 465 IDGVGiNAKLQHPLGVTWDKKRnlLYVADSYNHKIKVVDPKTKSCTTLAGTGDAsnvigssftESTFNEPGGLCIGENGQ 544
Cdd:cd14963     1 IYGPF-GDPLNKPMGVAVSDGR--IYVADTNNHRVQVFDYEGKFKKSFGGPGTG---------PGEFKYPYGIAVDSDGN 68

                          90       100
                  ....*....|....*....|....*.
gi 1910408677 545 lLYVADTNNHQIKVMDLETKTISVLP 570
Cdd:cd14963    69 -IYVADLYNGRIQVFDPDGKFLKYFP 93
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
451-571 2.18e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.47  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 451 GGERDPTNLFAFGDIDGVGINAKLQHPLGVTWDKKRNLLYVADSYNHKIKVVDPKTkscttlaGTGDASNVIGSSftest 530
Cdd:COG3391    44 VVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLAT-------GKVVATIPVGGG----- 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1910408677 531 fnePGGLCIGENGQLLYVADTNNHQIKVMDLET-KTISVLPV 571
Cdd:COG3391   112 ---PRGLAVDPDGGRLYVADSGNGRVSVIDTATgKVVATIPV 150
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 229-309 3.58e-08

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 56.05  E-value: 3.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 229 VTVDHvSKRLVIADTGHHRILVI-WKNGQIQYSIGGPNPGRKDgifSESTFNSPQGVAIMNN-IIYVADTENHLIRKIDL 306
Cdd:cd14951   201 VAALP-DGSVYVADTYNHKIKRVdPATGEVSTLAGTGKAGYKD---LEAQFSEPSGLVVDGDgRLYVADTNNHRIRRLDL 276


                  ...
gi 1910408677 307 EAE 309
Cdd:cd14951   277 PTE 279
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 165-301 5.97e-08

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 54.86  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 165 LVIFGPRGNMLFSLIGEGhkdklflytsialkyyKDRGQirdnkigiklykdslppspLLFPGKVTVDHVSkRLVIADTG 244
Cdd:cd14954   188 LQVFDPDGQFLRFFGSEG----------------SGNGQ-------------------FKRPRGVAVDDEG-NIIVADSG 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1910408677 245 HHRILVIWKNGQIQYSIGGPNPGrkdgifsESTFNSPQGVAIMNN-IIYVADTENHLI 301
Cdd:cd14954   232 NHRVQVFSPDGEFLCSFGTEGNG-------EGQFDRPSGVAVTPDgRIVVVDRGNHRI 282
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 223-323 2.26e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 52.94  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 223 LLFPGKVTVDHvSKRLVIADTGHHRILVIWKNGQIQYSIGGPNPGRKDgifsestFNSPQGVAIMN-NIIYVADTENHLI 301
Cdd:cd14954   117 FNYPWGVAVDS-EGRIYVSDTRNHRVQVFDSDGQFIRKFGFEGAGPGQ-------LDSPRGVAVNPdGNIVVSDFNNHRL 188

                          90       100
                  ....*....|....*....|..
gi 1910408677 302 RKIDLEAEMVSTvagIGIQGSD 323
Cdd:cd14954   189 QVFDPDGQFLRF---FGSEGSG 207
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 278-556 4.74e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 51.81  E-value: 4.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 278 FNSPQGVAI--MNNIiYVADTENHLIRKIDleaemvST---VAGIGIQGSdkeggaqGEEQpISSPWDVVIGTSGSegqr 352
Cdd:cd14955    15 FNSPSGIAVdsAGNV-YVADTGNNRIQKFD------STgtfLTKWGSSGS-------GDGQ-FYSPTGIAVDSDGN---- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 353 ddiLWIAMAGTHQI------------WallldcgrlpkkselkkGTClrfaGSGNEEnrnnayphkagFAQPSGLSLase 420
Cdd:cd14955    76 ---VYVADTGNHRIqkfdstgtfltkW-----------------GSS----GSGDGQ-----------FNSPSGIAV--- 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 421 DPWSCLFVADSESSTVRTVSlKDGAVKHLIGGerdptnlfaFGDIDGvginaKLQHPLGVTWDKKRNlLYVADSYNHKIK 500
Cdd:cd14955   118 DSAGNVYVTDSGNNRIQKFD-SSGTFITKWGS---------FGSGDG-----QFNSPTGIAVDSAGN-VYVADTGNNRIQ 181

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1910408677 501 VVDPKTKSCTT--LAGTGDasnvigssfteSTFNEPGGLCIgENGQLLYVADTNNHQI 556
Cdd:cd14955   182 KFTSTGTFLTKwgSEGSGD-----------GQFNAPYGIAV-DSAGNVYVADTGNNRI 227
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
216-370 4.99e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.62  E-value: 4.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 216 DSLPPSPLLFPGKVTVDHVSKRLVIADTGHHRILVIW-KNGQIQYSIggpnpgrkdgifseSTFNSPQGVAIM--NNIIY 292
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDlATGKVVATI--------------PVGGGPRGLAVDpdGGRLY 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1910408677 293 VADTENHLIRKIDLEA-EMVSTVAgIGiqgsdkeggaqgeeqpiSSPWDVVIGTSGSEgqrddiLWIAMAGTHQIWALL 370
Cdd:COG3391   126 VADSGNGRVSVIDTATgKVVATIP-VG-----------------AGPHGIAVDPDGKR------LYVANSGSNTVSVIV 180
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 233-558 5.14e-07

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 51.96  E-value: 5.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 233 HVSKRLVIADTGHHRILVIWKNGQIQysiggpnpgRKDGIF--SESTFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAE 309
Cdd:cd14960    25 SSSGRLVIADSNNQCVQVFSNDGQFK---------LRFGVRgrSPGQLQRPTGVAVtLNGDIIIADYDNKWVSIFSPDGK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 310 MVSTVagigiqGSDKeggaqgeeqpISSPWDVVIGTSGsegqrdDILWIAM-AGTHQIWallldcgrlpkKSELKKGTcl 388
Cdd:cd14960    96 FKSKI------GAGK----------LMGPKGVAVDRNG------HIIVVDNkACCVFIF-----------QPNGKLVT-- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 389 RFAGSGNEENRnnayphkagFAQPSGLSLASEDPwscLFVADSESSTVRtVSLKDGAVkhliggerdptnLFAFGDiDGV 468
Cdd:cd14960   141 RFGSRGNGDRQ---------FAGPHFAAVNNNNE---IIVTDFHNHSVK-VFNAEGEF------------LFKFGS-NGE 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 469 GiNAKLQHPLGVTWDKKRNLLyVADSYNHKIKVVDpktkscttlaGTGDASNVIGSSFteSTFNEPGGLCIGENGQLLyV 548
Cdd:cd14960   195 G-NGQFNAPTGVAVDSNGNII-VADWGNSRIQVFD----------SSGSFLSYINTSA--DPLYGPQGLALTSDGHVV-V 259

                         330
                  ....*....|
gi 1910408677 549 ADTNNHQIKV 558
Cdd:cd14960   260 ADSGNHCFKV 269
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 220-301 1.41e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 50.62  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 220 PSPLLFPGKVTVDHVSkRLVIADTGHHRILVIWKNGQIQYSIG--GPNPGRkdgifsestFNSPQGVAI--MNNIIyVAD 295
Cdd:cd14954   161 PGQLDSPRGVAVNPDG-NIVVSDFNNHRLQVFDPDGQFLRFFGseGSGNGQ---------FKRPRGVAVddEGNII-VAD 229


                  ....*.
gi 1910408677 296 TENHLI 301
Cdd:cd14954   230 SGNHRV 235
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 459-562 7.56e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 48.31  E-value: 7.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 459 LFAFGDiDGVGiNAKLQHPLGVTWDKKrNLLYVADSYNHKIKVVDP--KTKSCTTLAGTGDASnvigssftestFNEPGG 536
Cdd:cd14954    10 LLSFGK-EGSK-DGELCRPWGVAVDKD-GRIIVADRSNNRVQVFDPdgKFLRKFGSYGSRDGQ-----------FDRPAG 75

                          90       100
                  ....*....|....*....|....*.
gi 1910408677 537 LCIGENGQLlYVADTNNHQIKVMDLE 562
Cdd:cd14954    76 VAVNSRGRI-IVADKDNHRIQVFDLN 100
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 471-560 1.33e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 47.57  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 471 NAKLQHPLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTLAGTGDAsnvigssftESTFNEPGGLCIGENGQLlYVAD 550
Cdd:cd14955    59 DGQFYSPTGIAVDSDGNV-YVADTGNHRIQKFDSTGTFLTKWGSSGSG---------DGQFNSPSGIAVDSAGNV-YVTD 127

                          90
                  ....*....|
gi 1910408677 551 TNNHQIKVMD 560
Cdd:cd14955   128 SGNNRIQKFD 137
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 225-347 1.71e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 47.19  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 225 FPGKVTVDHVSKRLViADTGHHRILVIWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAIMNN-IIYVADTENHLIRK 303
Cdd:cd14955   111 SPSGIAVDSAGNVYV-TDSGNNRIQKFDSSGTFITKWGSF--GSGDG-----QFNSPTGIAVDSAgNVYVADTGNNRIQK 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1910408677 304 IDleaemvSTVAGIGIQGSDKEGGAQgeeqpISSPWDVVIGTSG 347
Cdd:cd14955   183 FT------STGTFLTKWGSEGSGDGQ-----FNAPYGIAVDSAG 215
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
163-369 1.96e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.94  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 163 PTLVIFGPRGNMLFSligEGHKDKLflytsiaLKYYKDRGQIRDNKIgiklykdslpPSPLLFPGKVTVDHvSKRLVIAD 242
Cdd:COG4257   104 PHGIAFDPDGNLWFT---DQGGNRI-------GRLDPATGEVTEFPL----------PTGGAGPYGIAVDP-DGNLWVTD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 243 TGHHRILVI-WKNGQIQySIGGPNPgrkdgifsestFNSPQGVAI-MNNIIYVADTENHLIRKIDLEAEMVSTVAGIGiq 320
Cdd:COG4257   163 FGANAIGRIdPDTGTLT-EYALPTP-----------GAGPRGLAVdPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPG-- 228

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1910408677 321 gsdkeggaqgeeqPISSPWDVVIGtsgsegqRDDILWIAMAGTHQIWAL 369
Cdd:COG4257   229 -------------GGARPYGVAVD-------GDGRVWFAESGANRIVRF 257
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 420-572 4.83e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.65  E-value: 4.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 420 EDP-WS---CLFVADSESSTVRTVSLKDGAVkhliggerdptNLFAFGDidgvginaklQHPLGVTWDKKRNLlYVADSy 495
Cdd:COG3386    11 EGPvWDpdgRLYWVDIPGGRIHRYDPDGGAV-----------EVFAEPS----------GRPNGLAFDPDGRL-LVADH- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 496 NHKIKVVDPKTKSCTTLAGTGDASN------VIGSS----FTESTFNEPG-----------------------GLCIGEN 542
Cdd:COG3386    68 GRGLVRFDPADGEVTVLADEYGKPLnrpndgVVDPDgrlyFTDMGEYLPTgalyrvdpdgslrvladgltfpnGIAFSPD 147

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1910408677 543 GQLLYVADTNNHQIKVMDL-ETKTISVLPVF 572
Cdd:COG3386   148 GRTLYVADTGAGRIYRFDLdADGTLGNRRVF 178
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 531-560 5.56e-05

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 45.72  E-value: 5.56e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1910408677 531 FNEPGGLCIGENGQLLyVADTNNHQIKVMD 560
Cdd:cd14959    21 FNSPSGFCLGEDEDIL-VADTNNHRIQVFD 49
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 531-558 9.18e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 39.69  E-value: 9.18e-05
                          10        20
                  ....*....|....*....|....*...
gi 1910408677 531 FNEPGGLCIGENGQLlYVADTNNHQIKV 558
Cdd:pfam01436   1 FNRPHGVAVDSNGDI-YVADSENHRVQV 27
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 477-560 1.09e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 44.87  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 477 PLGVTWDKKRNLlYVADSYNHKIKVVDPKTKSCTTL--AGTGDASnvigssftestFNEPGGLCIGENGQLlYVADTNNH 554
Cdd:cd14955    18 PSGIAVDSAGNV-YVADTGNNRIQKFDSTGTFLTKWgsSGSGDGQ-----------FYSPTGIAVDSDGNV-YVADTGNH 84


                  ....*.
gi 1910408677 555 QIKVMD 560
Cdd:cd14955    85 RIQKFD 90
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 225-305 1.52e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 44.10  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 225 FPGKVTVDHvSKRLVIADTGHHRILVIWKNGQIQYSIGgpNPGRKDGifsesTFNSPQGVAI-MNNIIYVADTENHLIRK 303
Cdd:cd14955   205 APYGIAVDS-AGNVYVADTGNNRIQKFDSSGTFITKWG--SEGSGDG-----QFNSPSGIAVdSAGNVYVADSGNNRIQK 276


                  ..
gi 1910408677 304 ID 305
Cdd:cd14955   277 FA 278
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 225-367 2.81e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 43.33  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 225 FPGKVTVDHvSKRLVIADTGHHRILVIWKNGQIQYSIGGPnpGRKDGifsesTFNSPQGVAI--MNNIiYVADTENHLIR 302
Cdd:cd14955   158 SPTGIAVDS-AGNVYVADTGNNRIQKFTSTGTFLTKWGSE--GSGDG-----QFNAPYGIAVdsAGNV-YVADTGNNRIQ 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1910408677 303 KIDLEAEMVSTVagigiqgsdkeGGAQGEEQPISSPWDVVIGTSGSegqrddiLWIAMAGTHQIW 367
Cdd:cd14955   229 KFDSSGTFITKW-----------GSEGSGDGQFNSPSGIAVDSAGN-------VYVADSGNNRIQ 275
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 278-303 7.07e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.38  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....*..
gi 1910408677 278 FNSPQGVAIM-NNIIYVADTENHLIRK 303
Cdd:pfam01436   1 FNRPHGVAVDsNGDIYVADSENHRVQV 27
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 409-564 1.05e-03

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 41.87  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 409 FAQPSGLSLASEDPwscLFVADSESSTVRTVSLkDGAVKHLIG-GER----DPTNLFAfgdidgvginaklqHPLGVTWD 483
Cdd:cd14958    75 FYMPHGLTIDPDGN---IWVTDVGLHQVFKFDP-EGKLLPLLTlGERgepgSDQTHFC--------------KPTDVAVA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 484 KKRNLlYVADSY-NHKIKVVDPKTKscttlagtgdasnVIGS----SFTESTFNEPGGLCIGENGQLlYVADTNNHQIKV 558
Cdd:cd14958   137 PDGDI-FVADGYcNSRIVKFSPDGK-------------LLKSwgepGSGPGQFNLPHSIALDEDGRV-YVADRENGRIQV 201


                  ....*.
gi 1910408677 559 MDLETK 564
Cdd:cd14958   202 FDADGK 207
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 407-570 1.32e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 407 AGFAQPSGLSLaseDPWSCLFVADSESSTVrtvsLKdgavkhLIGGERDPTNLfAFGDidgvginakLQHPLGVTWDKKR 486
Cdd:cd14952    91 TGLNDPTGVAV---DAAGNVYVADTGNNRV----LK------LAAGSNTQTVL-PFTG---------LSNPDGVAVDGAG 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 487 NLlYVADSYNHKIKVVDPKTKSCTTLAGTGDASnvigssftestfnePGGLCIGENGQlLYVADTNNHQIKVMDLETKTI 566
Cdd:cd14952   148 NV-YVTDTGNNRVLKLAAGSTTQTVLPFTGLNS--------------PSGVAVDTAGN-VYVTDHGNNRVLKLAAGSTTP 211


                  ....
gi 1910408677 567 SVLP 570
Cdd:cd14952   212 TVLP 215
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 479-582 8.41e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.72  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 479 GVTWDKKRNLLYVADSYNHKIKVVDpktkscttLAGTGDASNviGSSFTESTFNE--PGGLCIGENGqLLYVADTNNHQI 556
Cdd:COG3386   141 GIAFSPDGRTLYVADTGAGRIYRFD--------LDADGTLGN--RRVFADLPDGPggPDGLAVDADG-NLWVALWGGGGV 209

                          90       100
                  ....*....|....*....|....*...
gi 1910408677 557 KVMDLETKTISV--LPVFMSENATVDGP 582
Cdd:COG3386   210 VRFDPDGELLGRieLPERRPTNVAFGGP 237
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 408-570 8.84e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 38.73  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 408 GFAQPSGLSLaseDPWSCLFVADSesSTVRTVSLKDGAVKhliggerdPTNLfAFGDidgvginakLQHPLGVTWDKKRN 487
Cdd:cd14952     8 GLDGPGGVAV---DAAGNVYVADS--GNNRVLKLAAGSTT--------QTVL-PFTG---------LYQPQGVAVDAAGT 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677 488 LlYVADSYNHKIKVVDPKTKSCTTLAGTGdasnvigssftestFNEPGGLCIGENGQlLYVADTNNHQIKVMDLETKTIS 567
Cdd:cd14952    65 V-YVTDFGNNRVLKLAAGSTTQTVLPFTG--------------LNDPTGVAVDAAGN-VYVADTGNNRVLKLAAGSNTQT 128


                  ...
gi 1910408677 568 VLP 570
Cdd:cd14952   129 VLP 131
TlpA_like_ScsD_MtbDsbE cd03011
TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE ...
 78-173 9.08e-03

TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif. The Salmonella typhimurium ScsD is a thioredoxin-like protein which confers copper tolerance to copper-sensitive mutants of E. coli. MtbDsbE has been characterized as an oxidase in vitro, catalyzing the disulfide bond formation of substrates like hirudin. The reduced form of MtbDsbE is more stable than its oxidized form, consistent with an oxidase function. This is in contrast to the function of DsbE from gram-negative bacteria which is a specific reductase of apocytochrome c.


Pssm-ID: 239309 [Multi-domain]  Cd Length: 123  Bit Score: 36.89  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910408677  78 GKVVILDFFTYCCINCIHLLPDLHALEDTYSdkdgllIVGVHSAKFPNEKVldniKSAVLRYNITHPVVNDADASLWQEL 157
Cdd:cd03011    20 GKPVLVYFWATWCPVCRFTSPTVNQLAADYP------VVSVALRSGDDGAV----ARFMQKKGYGFPVINDPDGVISARW 89

                          90
                  ....*....|....*.
gi 1910408677 158 EVSCWPTLVIFGPRGN 173
Cdd:cd03011    90 GVSVTPAIVIVDPGGI 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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