1Q7F


Conserved Protein Domain Family
NHL_brat_like

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cd14959: NHL_brat_like 
Click on image for an interactive view with Cn3D
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Statistics
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PSSM-Id: 271329
Aligned: 19 rows
Threshold Bit Score: 381.233
Created: 21-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Pumilio binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                           #######                         #                      ####
1Q7F_A          9 KRQRMIYHCKFGE.[1].GVMEGQFTEPSGVAVN.[1].QNDIIVADTNNHRIQIFDKEGR.[ 2].FQFGECGKRD 73   fruit fly
ELU16635      519 KRQKMIYHCKFGE.[1].GVMEGQFTEPSGVAVN.[1].QNDIIVADTNNHRIQIFDKEGR.[ 2].FQFGECGKRD 583  Capitella teleta
ESP00015      473 RRQKMIYHCRFGE.[1].GVLEGQFTEPSGVAVN.[1].QNDIIVADTNNHRIQIFDKEGR.[ 2].FQFGECGKRD 537  owl limpet
ESO04923      496 KTNSMEIRTKFGQ.[1].GPGKGQFNAPHGFCLG.[1].DEDIVVADTNNHRIQVFDKSGE.[ 2].YQFGIPGLEE 560  Helobdella robusta
ESP03686      631 GLVIVAFRCKFGQ.[1].GPGKGQFNSPHGFCLG.[1].DQDIIVADTNNHRIQVFDKTGD.[ 2].YQFGIPGREE 695  owl limpet
XP_005112881  632 KTNAMQIRCKFGQ.[1].GPGKGQFNSPHGFCLG.[1].DEDIVVADTNNHRVQVFQKGGE.[ 2].YQFGIPGREE 696  California sea hare
ESO00823      190 RRIKMEYHCKFGE.[1].GNEAGLFTEPSGVAVG.[1].DNEILVADANNHRIQVFDSTGA.[13].SSGDVRGSQN 265  Helobdella robusta
XP_005105088  829 CRTRTSFVHVFGD.[1].GRGEYAFTEPSGQAYF.[1].DGSYVICDTNNHRIVYYNKDHE.[23].GQRGKGFTRQ 914  California sea hare
P34611        566 KRQKMIYHCKFGE.[1].GVMEGQFTEPSGVAVN.[1].QGDIVVADTNNHRIQVFDKEGR.[ 2].FQFGECGKRD 630  Caenorhabditis elegans
Q9W378        913 KATPMQIRCKFGS.[1].GTAKGQFNSPHGFCLG.[1].DEEIIVADTNNHRIEVFDKMGA.[ 2].FQFGVAGKEE 977  fruit fly

Feature 1                 #                     #                                                
1Q7F_A         74 .[1].QLLYPNRVAVV.[1].NSGDIIVTERS     PTHQIQIYNQYGQFVRKFGATILQHPRGVTVDNKGRIIVVEC 139  fruit fly
ELU16635      584 .[1].QLLYPNRVAVV.[1].TSGDIVVTERS     PTHQVQIYNQYGQFVRKFGASILQHPRGVTVDDKGRIIIVEC 649  Capitella teleta
ESP00015      538 .[1].QLLYPNRVSVV.[1].ASGDIIVTERS     PTHQIQIYNQYGQFVRKFGANVLQHPRGVTVDNKGRIIIVEC 603  owl limpet
ESO04923      561 .[1].QLWYPRKVAVI.[1].TSGRYVVCDRG.[1].ERSRMQLFTRTGQFIKKIAIRYIDIVAGLAITSQGHIVAVDS 627  Helobdella robusta
ESP03686      696 .[1].QLWYPRKVAVM.[1].ASARYVVCDRG.[1].ERSRMQIFTKNGHFVKKIAIRYIDIVAGLAITAAGNIAAVDS 762  owl limpet
XP_005112881  697 .[1].QLWYPRKVAVI.[1].KTGKFVVCDRG.[1].ERSRMQIFNRNGNFLRKIAIRYIDIVAGLAITPEGYIVAVDS 763  California sea hare
ESO00823      266 .[2].DLVYPNRLAVN.[1].VTGCIYVTERS     PTHQVRVYDETGRFVRRFGAHVLQHPRGITVDRLGRIIVIEC 332  Helobdella robusta
XP_005105088  915 .[2].YLYFPNRVAIC.[1].VTKHIVATERP     PSHDVQIFTIEGDFVRCFGGSVLQHPRGVTVDENGVIIVVEC 981  California sea hare
P34611        631 .[1].QLLYPNRVAVN.[1].TTGDFVVTERS     PTHQIQVYNQYGQFLRKFGANILQHPRGVCVDSKGRIIVVEC 696  Caenorhabditis elegans
Q9W378        978 .[1].QLWYPRKVAVM.[1].NNGKFVVCDRG.[1].ERSRMQIFSKCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVDS 1044 fruit fly

Feature 1                                                                                         
1Q7F_A        140 .[1].VMRVIIFDQNGNVLHKFGCSK.[1].LEFPNGVVVND.[1].QEIFISDNRAHCVKVFNYEGQYLRQIGGEGITN 207  fruit fly
ELU16635      650 .[1].VMRVIIFDQMGNVLQKFGCSK.[1].LEFPNGVVVND.[1].EEIFISDNRAHCVKVFSYQGAFLRQIGGEGITN 717  Capitella teleta
ESP00015      604 .[1].VMRVIIFDQYGNVLNKFGCSK.[1].LQFPNSVVVND.[1].EEIFISDNRAHCVKVFNYQGLYLRQIGGEGVTN 671  owl limpet
ESO04923      628 .[1].SPTVFCISESGELIKWFDCSD.[1].MREPSDIAVSG     KDYYVCDFKGHCVVVFNEDGQFLHRIGCETITN 694  Helobdella robusta
ESP03686      763 .[1].SPTVFCIAESGDLLKWFDCSD.[1].MREPSDIAVSG     SEYFVCDFKGHCVVVFNEEGQFMRRIGCENITN 829  owl limpet
XP_005112881  764 .[1].SPTVFWISETGDLLKWFDCSD.[1].MREPSDIAINN     YEYFVCDFKGHCVVVFSKDGQFLRRIGCENITN 830  California sea hare
ESO00823      333 .[1].VMRVVIFNSSGSVLNRFIVEK.[1].VNFPNGVAVND.[1].EEIFISDNRRHGVVVFDYQGAFLRTIGGIGITN 400  Helobdella robusta
XP_005105088  982 .[1].VMKLTMFDHDGNQLASHSLAK.[1].LEFPNDVAAKD     GKIYISDNRGHCVQVFDYDAKFLQKIGNDNLTY 1048 California sea hare
P34611        697 .[1].VMRVIIFDMFGNILQKFSCSR.[1].LEFPNGVCTND.[1].NEILISDNRAHCIKVFSYEGQYLRQIGGEGVTN 764  Caenorhabditis ele...
Q9W378       1045 .[1].SPTVFVISEEGELVRWFDCSD.[1].MREPSDIAIRD     NDFYVCDFKGHCVAVFQDDGTFLYRIGNEKVTC 1111 fruit fly

Feature 1                                                                                         
1Q7F_A        208 YPIGVGINSNGEILIADNHNN     FNLTIFTQDGQLI     SALE.[1].KVKHAQCFDVALM     DDGSVVLAS 268  fruit fly
ELU16635      718 YPIGVGINAAGEILIADNHNN     FNLTTFTQDGQLV.[1].ALES     KVKHAQCFDVALM     DEGSIVLAS 778  Capitella teleta
ESP00015      672 YPIGVGINSAGEVLVADNHNN     FNLTNFTQDGQLI.[1].ALES     KVKHAQCFDVALM     DDGSVVLAS 732  owl limpet
ESO04923      695 YPNGIDISDAGDVLIGDSHGN.[1].FHVAVFQRDGSLI.[1].EFEC.[1].YVKVSRCCGLKIT     SEGYIVTLA 757  Helobdella robusta
ESP03686      830 YPNGIDISDDGDVLIGDSHGN.[1].FHVGVFQRDGSLI.[1].EFQC.[1].YVKVSRCCGLKIT     SEGYVVTLA 892  owl limpet
XP_005112881  831 YPNGIDISGHGDVLIGDSHGN.[1].FHVGVFQRDGSLI.[1].EFQC.[1].YVKVSRCCGLKIT     SEGYIVTLA 893  California sea hare
ESO00823      401 YPIGVGINSAGEVVVADNHNN     FNVTLFTQDGQLI.[1].ALES     RVKHAQCFDTALM     GDGSIVLSS 461  Helobdella robusta
XP_005105088 1049 FPIGVSINYLNQIVVTDNHNT     FNITVFDLEGRAS.[1].IFES     ITKHAQCHNVAVH.[1].TKLELMLTT 1110 California sea hare
P34611        765 YPIGVGINSLGEVVVADNHNN     FNLTVFSQDGTMI.[1].ALES     RVKHAQCFDVALV     DDGSVVLAS 825  Caenorhabditis ele...
Q9W378       1112 FPNGIDISNAGDVLIGDSHGN.[1].FHVACYSREGALQ.[1].EFEC.[1].HVKVSRCCGLKIT     SEGYVVTLA 1174 fruit fly

Feature 1                         
1Q7F_A        269 K     DYRLYIYRYV 279  fruit fly
ELU16635      779 K     DYRLYIYRYA 789  Capitella teleta
ESP00015      733 K     DYKLYIYKYM 743  owl limpet
ESO04923      758 K.[1].NQHVLVLNTL 769  Helobdella robusta
ESP03686      893 K.[1].NHHVLVLNTL 904  owl limpet
XP_005112881  894 K.[1].NHHVLVLNTL 905  California sea hare
ESO00823      462 K     DYRIYIYHYG 472  Helobdella robusta
XP_005105088 1111 K     DCNVYFFNYD 1121 California sea hare
P34611        826 K     DYRLYLYRFL 836  Caenorhabditis elegans
Q9W378       1175 K.[1].NHHVLVLNTL 1186 fruit fly

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