FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561 296 IHKCEECGKQFTTSGNLKRHLR--IHSGE--KPYVCIH--CQRQFADPGALQRHVRIHTGEKPCQCVM--CGKAFTQAS- 366
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLn 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561 367 -SLIAHVRQHTG---EKPYVCE--RCGKRFVQSSQLANHIRHHDNIRPH--KCSVCSKAFVNVGDLSKHIIIHTGEKPYL 438
Cdd:COG5048  369 nEPPQSLQQYKDlknDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*...
gi 664728561 439 CdkCGRGFNRVDNLRSHV 456
Cdd:COG5048  449 C--SILKSFRRDLDLSNH 464

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   14 LNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQ---KDVVHLDIS--NAAGLGQVLEFMYTAKLsLSSEN 88
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQeseSSVSEITLDdvSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|.
gi 664728561   89 VDDVLAVASFLQMQDIITACH 109
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCE 100

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561 296 IHKCEECGKQFTTSGNLKRHLR--IHSGE--KPYVCIH--CQRQFADPGALQRHVRIHTGEKPCQCVM--CGKAFTQAS- 366
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLn 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561 367 -SLIAHVRQHTG---EKPYVCE--RCGKRFVQSSQLANHIRHHDNIRPH--KCSVCSKAFVNVGDLSKHIIIHTGEKPYL 438
Cdd:COG5048  369 nEPPQSLQQYKDlknDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*...
gi 664728561 439 CdkCGRGFNRVDNLRSHV 456
Cdd:COG5048  449 C--SILKSFRRDLDLSNH 464

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 664728561  311 NLKRHLRIHSGEKPYVCIHCQRQFA 335
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 664728561   297 HKCEECGKQFTTSGNLKRHLRIH 319
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   1 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQ---KDVVHL--DISNAAGLGQVLE 75
Cdd:cd18324    1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQldkRDIVHLnsDIVTAPAFALLLE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 664728561  76 FMYTAKLSLSSENVDDVLAVASFLQMQDIITACHalKSLAELAASPGENTE 126
Cdd:cd18324   81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCK--KKLKEKATTEADSTK 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVD----QKDVVHLDISNAAGLGQVLEFMYTAK 81
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNsssqKNDVFHLDIKNVGGIGQILDFMYTSH 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 664728561  82 LSLSSENVDDVLAVASFLQMQDIITACHAL 111
Cdd:cd18233   81 LDLNQDNVQVMLDIAQCLQVQNVLNMCYTF 110

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   14 LNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQ---KDVVHLDIS--NAAGLGQVLEFMYTAKLsLSSEN 88
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQeseSSVSEITLDdvSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|.
gi 664728561   89 VDDVLAVASFLQMQDIITACH 109
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCE 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   1 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQ----KDVVHL--DISNAAGLGQVL 74
Cdd:cd18956    1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRpaggRDTVRLngDIVTAPAFGRLL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 664728561  75 EFMYTAKLSLSSENVDDVLAVASFLQMQDIITAC 108
Cdd:cd18956   81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   3 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLF-----VDQKDVVHLDISNAAGLGQVLEFM 77
Cdd:cd18198    5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFtsgavVDQQNVYEIDFVSPEALTALLEFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 664728561  78 YTAKLSLSSENVDDVLAVASFLQMQDIITAC 108
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKD-VVHLDIS--NAAGLGQVLEFMYTAKL 82
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDnIVFLDQSqvSADGFQKLLEFIYTGNL 80

                         90       100
                 ....*....|....*....|....*.
gi 664728561  83 SLSSENVDDVLAVASFLQMQDIITAC 108
Cdd:cd18217   81 NLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   4 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFV-DQKDVVHLDISN----AAGLGQVLEFMY 78
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFInHQHTTAQLNLSNmkisAECFDLILQFMY 81

                         90       100
                 ....*....|....*....|....*.
gi 664728561  79 TAKLSLSSENVDDVLAVASFLQMQDI 104
Cdd:cd18192   82 LGKIMTAPSDFEQLKVAMNYLQLYYI 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   3 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVD------------QKDVVHLDISNAAGL 70
Cdd:cd18327    5 FPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGggggsgdlgaggGQDVCELDFVGPEAL 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 664728561  71 GQVLEFMYTAKLSLSSENVDDVLAVASFLQMQDIITAC 108
Cdd:cd18327   85 GALLEFAYTATLTISSSNMREVLRAARLLEIPCVADAC 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   9 HVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFV-------DQKDVVHLDISNAAGLGQVLEFMYTAK 81
Cdd:cd18201    7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCftnkescDQTTVTHLDVVAVQGFSVILDFMYSGN 86

                         90       100       110
                 ....*....|....*....|....*....|
gi 664728561  82 LSLSSENVDDVLAVASFLQMQDIITACHAL 111
Cdd:cd18201   87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNF 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   3 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLF-----VDQKDVVHLDISNAAGLGQVLEFM 77
Cdd:cd18328    5 FPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFtagtlADQPYVYEIDFVTPEALSAILEFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 664728561  78 YTAKLSLSSENVDDVLAVASFLQMQDIITAC 108
Cdd:cd18328   85 YTSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQ------------KDVVHLDISNAAGLGQV 73
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQasprlvlvspagKCVLDLHHVTVTGFAPL 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 664728561  74 LEFMYTAKLSLSSENVDDVLAVASFLQMQDIITAC 108
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVD--QKDVVHLD-ISNAAgLGQVLEFMYTAKL 82
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDftQEPLVEIEgVSNMA-FRHLIEFTYTAKL 79

                         90       100
                 ....*....|....*....|....*.
gi 664728561  83 SLSS-ENVDDVLAVASFLQMQDIITA 107
Cdd:cd18221   80 MVQGeEEANDVWKAAEYLQMQEAIKA 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   4 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLfVDQKDVVHLD--ISNAAGLGQVLEFMYTAK 81
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSL-VLHDNLIHLDqdMVSPTVFQQILDFIYTGK 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 664728561  82 LSLSSE---NVDDVLAVASFLQMQDIITAC 108
Cdd:cd18216   80 LLDSLFeepNLSEVLAAANYLQLPDLAALC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDVVH----LDISNAAGLGQVLEFMYTAK 81
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQsiymLEGMVAETFGALLEFIYTGC 85

                         90       100
                 ....*....|....*....|....*.
gi 664728561  82 LSLSSENVDDVLAVASFLQMQDIITA 107
Cdd:cd18212   86 LQVGEKSLEQILATAQFLKVNDLVKA 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDvVHLDIS-----NAAGLGQVLEFMYTA 80
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQAD-AELNITlpeevTVKGFEPLIQFAYTA 88

                         90       100
                 ....*....|....*....|....*...
gi 664728561  81 KLSLSSENVDDVLAVASFLQMQDIITAC 108
Cdd:cd18277   89 KLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   5 QHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQK----DVVHLDIS-NAAGLGQVLEFMYT 79
Cdd:cd18332    1 RHSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVgegvSVLTLPSGlEARGFQLLLDFMYT 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 664728561  80 AKLSLSSENVDDVLAVASFLQMQDIITACHA 110
Cdd:cd18332   81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRR 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   1 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQK----DVVHLDIS-NAAGLGQVLE 75
Cdd:cd18331    2 IQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLkcnlSVINLDPEiNPEGFNILLD 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 664728561  76 FMYTAKLSLSSENVDDVLAVASFLQMQDIITACH 109
Cdd:cd18331   82 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   3 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVdQKDVVHL--DISNAAGLGQVLEFMYTA 80
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVL-HDNLINLdtDMVNPTVFRQILDFIYTG 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 664728561  81 KLSLSSE----NVDDVLAVASFLQMQDIITAC 108
Cdd:cd18334   80 KLLTSDQpgeqNFNALLTAASYLQLHDLAALC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDV-VHLDISNAAGLGQVLEFMYTAKLSL 84
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGsVVLPESFAEVFGLLLDFFYTGELAL 80

                         90       100
                 ....*....|....*....|....*...
gi 664728561  85 SSENVDDVLAVASFLQMQDIITACHALK 112
Cdd:cd18232   81 TRENRDRVLLAAKELRVPEAVELCQRFQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   1 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVDQKDVVhLDISNAA---GLGQVLEFM 77
Cdd:cd18290    5 MEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAV-VELPAAVqpqSFQQILSFC 83

                         90       100
                 ....*....|....*....|....*...
gi 664728561  78 YTAKLSLSSENVDDVLAVASFLQMQDII 105
Cdd:cd18290   84 YTGRLSMNVGDQFLLMYTAGFLQIQEIM 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664728561   6 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFKMLFVD-----QKDVVHLDISNAAGLGQVLEFMYTA 80
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSemsekGKSEVELQGLTASTMEILLDFVYTE 83