Conserved Protein Domain Family
BTB_POZ_ZBTB38_CIBZ
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cd18223: BTB_POZ_ZBTB38_CIBZ 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.
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Statistics
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PSSM-Id: 349532
Aligned: 6 rows
Threshold Bit Score: 215.422
Created: 12-Sep-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Q8NAP3         15 HSDTVLSILNEQRIRG.[1].LCDVTIIVEDTKFKAHSNVLAASSLYFKNIF.[4].ICISSHVLELDDLKAEVFTEILN 89   human
XP_018121370   12 HSDTLLCCLNEQRMQG.[1].LCDVTIVVEDTKFKAHRNILAASSLYFRKQF.[4].ILIQGHVLELTDFKADTFTEILN 86   African clawed frog
XP_014353114   16 HIQTVLHNLNEQRIQG.[1].LCDVTIVVEDIKFKAHKNVLAASSLYFKSAF.[4].FLFSSHVLEIPELKAEIFAKILH 90   coelacanth
XP_007893134   15 HSQTVLCCLNEQRTRG.[1].LCDVTIVVEDSKFKAHKNVLAAASLYFKNLF.[4].LWLVGHVLELPDFKADVFADVLH 89   elephant shark
OPJ79112       25 HSDTVLSILNEQRIRG.[1].LCDVTIIVEDTKFKAHSNVLAASSLYFKNIF.[4].ICISGHVLELDDLKAEVFTEILN 99   Patagioenas fascia...
KKF29247      142 HPHTVLSKLDEQRSQG.[1].FCDVTIVVEDVKFRAHKNILAACSGYFRNAL.[4].TWSSSQVLELMDLKSEVFASILN 216  large yellow croaker


Q8NAP3         90 YIYSSTVVVK.[2].ETVTDLAAAGKKLGI.[1].FLEDLTDRNFS 128  human
XP_018121370   87 YIYSSKIAVK.[2].GALRDIADAGKKLGI.[1].FLENIKNANSS 125  African clawed frog
XP_014353114   91 FIYSAKVVIK.[2].EKVKDLVAAGKSLGI.[1].FLENLTLQSNR 129  coelacanth
XP_007893134   90 FIYSDKVPMR.[2].DRASDLVEAGRRLGI.[1].FLQTLVPQQDS 128  elephant shark
OPJ79112      100 YIYSSTVVVK.[2].ETVTDLAAAGKKLGI.[1].FLEDLTDANFS 138  Patagioenas fasciata monilis
KKF29247      217 FIYCSKVTSP.[2].EDTGGLVAAGKRLGI.[1].FLEKLAEQERQ 255  large yellow croaker
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