Conserved Protein Domain Family
IKKbetaNEMObind

pfam12179: IKKbetaNEMObind

I-kappa-kinase-beta NEMO binding domain

This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.

Links

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Source:	pfam
Taxonomy:	Euteleostomi
PubMed:	1 link

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl13595

Statistics

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PSSM-Id:	463485
Aligned:	22 rows
Threshold Bit Score:	44.6034
Created:	24-Mar-2022
Updated:	17-Oct-2022

Structure

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PubMed References

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Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

O88351       706 EELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWL 742 house mouse
XP_023406842 610 EELVAEAHTLCSQLENVMQDTMKEQGQSFMALDWSWL 646
XP_007477013 739 EELVTETQSLCTQLQSMMEDAMKKQDQSFMTLDWSWL 775
XP_003441159 686 HQLLDENQRYLSQLTSLLQDATQEMEHSIMDQDWSWT 722
XP_005811961 687 QQLLDENQRYLNHLTSLMQDATQELKQSVMDQDWSWV 723
XP_011601695 687 HQLLEENENYLSQLTSLLQETTRDPEYSIMEQDWSWT 723
2_pfamImport   1 HQLLEENENYLSQLTSMLQETTKETEHTVVEQDWSWT 37 
XP_001509921 706 EDLVVEAQNLCTQLENAMQDTMKEQDRSFMALDWSWL 742
XP_004775760 706 GELVTEAHTLCSQLEHAMQDTIKEQDQSLRSLDWSWL 742
BAF62302     706 EDLVAEAHSLCAQLENVLQDTMKEQDQSLKSLDWSWL 742

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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