Conserved Protein Domain Family
PHD_JADE3
?
cd15681: PHD_JADE3 
PHD finger found in protein Jade-3 and similar proteins
Jade-3, also termed PHD finger protein 16 (PHF16), is a plant homeodomain (PHD) zinc finger protein that is closely related to Jade-1, which functions as an essential regulator of multiple cell signaling pathways. Like Jade-1, Jade-3 is required for ING4 and ING5 to associate with histone acetyl transferase (HAT) HBO1 and Eaf6 to form a HBO1 complex that has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3, and is responsible for the bulk of histone H4 acetylation in vivo. Jade-3 contains a canonical Cys4HisCys3 PHD domain followed by a non-canonical extended PHD (ePHD) domain, Cys2HisCys5HisCys2His, both of which are zinc-binding motifs. This model corresponds to the canonical Cys4HisCys3 PHD finger.
Links
?
Statistics
?
PSSM-Id: 277151
Aligned: 6 rows
Threshold Bit Score: 114.298
Created: 30-Aug-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on structure evidence that human BRD1 (2KU3) binds two Zn2+ ions through its PHD finger.
  • Comment:The PHD zinc finger is characterized as Cys4HisCys3.
  • Citation:PMID 7583761
  • Citation:PMID 7701562
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #             #  #    #  #            #  #    
Q92613       202 ICDVCRSPDSEEGNDMVFCDKCNVCVHQACYGILKVPEGSWLCRSCVLGI 251 human
EMC84507     204 ICDVCRSPDSEDGNDMVFCDKCNICVHQACYGILKVPEGSWLCRTCVLGI 253 rock pigeon
Q0P4S5       204 ICDVCRSPDSEEGNDMVFCDRCNICVHQACYGILKVPEGSWLCRTCVLGL 253 western clawed frog
Q7ZVP1       203 ICDVCRSPDSEEGNDMVFCDKCNICVHQACYGIVKVPDGNWLCRTCVLGI 252 zebrafish
XP_006009944 163 ICDVCRSPDSEEGNDMVFCDKCNICVHQACYGILKVPEGSWLCRTCVLGI 212 coelacanth
XP_007889279 204 ICDVCRSPDSEEGNEMVFCDRCNICVHQACYGILKVPEGSWLCRTCVLGI 253 elephant shark

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap