Conserved Protein Domain Family
YjgF_YER057c_UK114_like_3
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cd06151: YjgF_YER057c_UK114_like_3 
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Links
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Statistics
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PSSM-Id: 100008
Aligned: 17 rows
Threshold Bit Score: 153.63
Created: 17-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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homotrimerputative active
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ##  # #     # # ##                                                           # #
ZP_01518223   47 IAAAVEIptdarTVYLSGKVPpvvdksrta--------------tdpaayggdTEGQTVAILKGLEEQLKSMNltmsDVV 112 Comamonas testo...
XP_001694009 197 ILSGVTVpatyaVYWSSGTVPavknasapa---------------gsrerfgnTTEQAISILERMSTLLAEAGltlaDAT 261 Chlamydomonas r...
YP_701981     54 IAQGVAIgggtaVYKSSGIGPgasnktapegtpesyidtdvfaggalpagvtiTEAQGINALKRIRDNLEAQGltleDVV 133 Rhodococcus sp....
XP_001694009 352 ILSGVSVptghaYYHSSGTVPaaknasapr---------------gsrerygnTTEQAISVLTRIQALLREQGlgmqDAV 416 Chlamydomonas r...
YP_191592     48 ISAAVQVpagaeTVYVSGLGPapdra-----------------------sgttTAEQTRSALDQISGALGHFGmtlqDVV 104 Gluconobacter o...
YP_728596     51 FAEVIEIpanaqLLVLSGVGPtvanasapp---------------dtaasygdTATQTRSVLGQIERILQDRGyrmgDIV 115 Ralstonia eutro...
NP_792803     15 ISQTVTVpasasLIFISGTLPdladphapa---------------gtpaaygnTQVQTVSVFNKLRRILQQQDldlgDIV 79  Pseudomonas syr...
ZP_02845159   52 ISSAVAMpagtaTFETSGTVPsvvnkegk----------------tiyerygdTEKQGLSVLKNIETLLKEQGlsmkDVT 115 Paenibacillus s...
ZP_01687293   49 ILRGVAIpkgkkTFLTSGLVAplldstaak--------------tnahkrrgdTYTQSIHTLQRIEKILQEAGlemkDVV 114 Microscilla mar...
YP_001602698  38 IATAIEVppgasTIYLSGTGAqpvnksakp---------------mtlaaygdTETQVRGALTQIQGQLAKLKltmgDVV 102 Gluconacetobact...

Feature 1        # # #                #  #   #                             #########          # #
ZP_01518223  113 KMQVFLvadpakgnkmDFAGFMRGYTQFFgtaa----------------------qpnLPARSAFQIaalanpaWYVEIE 170 Comamonas testo...
XP_001694009 262 YLRVFLvadphlnntvDYQGWFNAYALYFskp-----------------------gsvKTARSTMAVtslvnadWLIEIE 318 Chlamydomonas r...
YP_701981    134 TMRVFLdnapg-tdraDYAGWNRAYRQFFantnldtgdtelvplgtaepaapmernsaRPSRFALEVaslpaagWLVEVE 212 Rhodococcus sp....
XP_001694009 417 YVRCYLvadpflngtvDFAGWNVAYAQFFnip-----------------------gstRVARSTLAVaglvdaeWLVEIE 473 Chlamydomonas r...
YP_191592    105 QMHVYLvadpr-lghmDFDGMMQTYRARFrs--------------------------gFPARTVIEVphltnqhWLVEID 157 Gluconobacter o...
YP_728596    116 SMQALIvadpa-tgepDFTGFSSAYKQYFgtdk----------------------qpnVPVRTRAEVlrlvppgWLVEVT 172 Ralstonia eutro...
NP_792803     80 QLRVFLvgaeetggklDFAGLQAGYTQFFgtpe----------------------qplKPARTALQVvalplpgALIEVE 137 Pseudomonas syr...
ZP_02845159  116 YLRVYIapdaakdgkfDFDGWNKAYAKYFntke----------------------npvKTARSTVGVaslvnsdWLIEIE 173 Paenibacillus s...
ZP_01687293  115 YLRVYIapdaqnsqepDFDAWFKAYNKFFnnaq----------------------nptKVARTTLGVyrlarpdILVEIE 172 Microscilla mar...
YP_001602698 103 QMHIYMvadpk-lgkiDFPGMMKAYTEFFgtka----------------------qpnLPTRSAFEVahlanpgWLVEIE 159 Gluconacetobact...

Feature 1         # 
ZP_01518223  171 VVA 173 Comamonas testosteroni KF-1
XP_001694009 319 LWA 321 Chlamydomonas reinhardtii
YP_701981    213 VDA 215 Rhodococcus sp. RHA1
XP_001694009 474 LVA 476 Chlamydomonas reinhardtii
YP_191592    158 VVA 160 Gluconobacter oxydans 621H
YP_728596    173 VMA 175 Ralstonia eutropha H16
NP_792803    138 AVA 140 Pseudomonas syringae pv. tomato str. DC3000
ZP_02845159  174 AVA 176 Paenibacillus sp. JDR-2
ZP_01687293  173 AVA 175 Microscilla marina ATCC 23134
YP_001602698 160 VTA 162 Gluconacetobacter diazotrophicus PAl 5

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