1J79


Conserved Protein Domain Family
DHOase

?
cd01294: DHOase 
Click on image for an interactive view with Cn3D
Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is monofunctional and mainly dimeric.
Statistics
?
PSSM-Id: 238619
Aligned: 18 rows
Threshold Bit Score: 442.492
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                # #                                                                    
1J79_A        7 LKIRRPDDWHLHLRDGDMLKTVVPYTSEIY-GRAIVMPNLAPPVTTVEAAVAYRQRILDavpaphDFTPLMTCYLTDslD 85  Escherichia coli
ZP_00018287   3 VTLFAPLDMHLHLREGAMLRLVAPFSAAQF-AGAVIMPNLVPPVDNADRLARYHEEIRAavd-pyPFLPLMTLFFRPy-D 79  Chloroflexus aur...
Q8K9L2        8 IKIIKPDDWHVHLRDNEILKKVSQYTGTFY-KRAIIMPNLEEPITNCFRSISYRRRILNsmtpntAFQPLMICYLTEktS 86  Buchnera aphidic...
NP_281453     1 MKLKNPLDMHLHLRDNQMLELIAPLSARDF-CAAVIMPNLIPPLCNLEDLKAYKMRILKack-deNFTPLMTLFFKNy-D 77  Campylobacter je...
P31301        6 ITIPAPGDFHVHLRQGKMSELVTPHVAEGGvSLAYVMPNLVPPITSTQQAMEYLERLAAva---pQTMFVGTLYLSPdlT 82  Ustilago maydis
NP_908104     4 LTLIDPLDMHLHLREGETLKRVLPYTANLF-SGAVVMPNLKTPLCTTQEVLSYKKSIEEacp-keRFIPFMTLFFHEnlT 81  Wolinella succin...
Q9UTI0        3 LKIPGLADMHVHLRQDNMLKAVVPTVAEGGvSVAYVMPNLIPPITTVDACLQYKKEIEQld---sKTTYLMSLYLSPetT 79  fission yeast
P20051        5 IDLGLTCDMHVHVREGAMCELVTPKIRDGGvSIAYIMPNLQPPITTLDRVIEYKKTLQKla---pKTTFLMSFYLSKdlT 81  baker's yeast
AAM46078     26 LVMPLISDMHTHLRQDEMAEFVTPMIKKGGcRCVLVMPNTIPPVTTCAQAAAYRERLVRid---pNVDYMMTLFLSPevS 102 Toxoplasma gondii
P56465        3 ITLFDPIDAHLHVRENALLKAVLGYSSEPF-SAAVIMPNLSKPLIDTPTTLEYEEEILNhs---sNFKPLMSLYFNDglT 78  Helicobacter pylori
Feature 1                       #                                      #                        
1J79_A       86 PNELERGFNegvFTAAXLYPANATTNSSHGVTSv--DAIMPVLERMEKIGMPLLVHGEVTHad------idIFDREARFI 157 Escherichia coli
ZP_00018287  80 AQTLQALREh--IFAIKLYPEGVTTNSAGGVSDl--TAIEPTLAMMEELGIPLLVHGESHGf---------VLDREAEFL 146 Chloroflexus aur...
Q8K9L2       87 PEELQQGFFkkiFVGAKLYPHCSTTNSKYGIKNi--NNIYHLFNIMEKIKMPLLIHGEENNln------idIYDREAKFI 158 Buchnera aphidic...
NP_281453    78 EKFLYSAKDe--IFGIKLYPAGITTNSNGGVSSfdiEYLKPTLEAMSDLNIPLLVHGETNDf---------VMDRESNFA 146 Campylobacter je...
P31301       83 PAEIAEGAQn-gVRGVKSYPRGVTTNSDSGIEDy--ETYYPIFEEMQKHDMVLNLHGELPSnada---gicVLNAEEKFL 156 Ustilago maydis
NP_908104    82 LEELTLAQIe-gIRIIKLYPKGSTTGSEAGVAQiltPKTLQILETMQSLGLILSMHGESGGf---------VLEREFEFL 151 Wolinella succin...
Q9UTI0       80 PEVIYEAAKk-gIRGVKSYPKGATTNSESGVESy--EPFYPTFAAMQETGMILNIHGEVPPskd-----ntVFTAEPKFL 151 fission yeast
P20051       82 PDLIHEAAQqhaIRGVKCYPAGVTTNSAAGVDPndfSAFYPIFKAMQEENLVLNLHGEKPSvhdgdkepihVLNAEEAFL 161 baker's yeast
AAM46078    103 ADDLRQNAKmchVTGIKSYPKGVTTNSDQGVESy--EQYYGIFEAMQELGLTLHLHGEVPGv--------aPLDAEEAFI 172 Toxoplasma gondii
P56465       79 LEELQCAKEk-gVRFLKLYPKGMTTNAQNGTSDllgEKTLEVLENAQKLGFILCIHAEQTGf---------CLDKEFLCH 148 Helicobacter pylori
Feature 1                          #                                                            
1J79_A      158 eSVMEPLRQRLTALKVVFEHITTKDAADYVRDGne--------rLAATITPQHLMFNRNHmlvg---------------- 213 Escherichia coli
ZP_00018287 147 -PVYERWARTFPRLRIVMEHITTAAALDLLDRYp---------nLFATVTLHHLLITLDDvagg---------------- 200 Chloroflexus aur...
Q8K9L2      159 eNTLKPLRKKFPELKIILEHITTEEAISYIEECns-------syLAGTITPHHLMLNRNNmfid---------------- 215 Buchnera aphidic...
NP_281453   147 -KIYEKLAKHFPRLKIVMEHITTKTLCELLKDYe---------nLYATITLHHLIITLDDvigg---------------- 200 Campylobacter je...
P31301      157 -THLFKMHGEFPKLKIVLEHATTRKAVEAVKQCgd--------tVGCTITPHHLELIVDDwag----------------- 210 Ustilago maydis
NP_908104   152 -SVYEEIARTFPKLQIIIEHMSDARSLERIERFs---------nLYGTLTLHHLLYTLDDllgq---------------- 205 Wolinella succin...
Q9UTI0      152 -PTLLDLHQRFPKLKIVLEHCTTADAVEAVKACge--------sVAGTITAHHLYLTQKDwqd----------------- 205 fission yeast
P20051      162 -PALKKLHNDFPNLKIILEHCTSESAIKTIEDInknvkkatdvkVAATLTAHHLFLTIDDwag----------------- 223 baker's yeast
AAM46078    173 -PFFEQIHSRFPSLKIVLEHVSTAAAIQAVKRMpa--------nVAATITPHHLMLTVDDvvkpdaikrametaahrglc 243 Toxoplasma gondii
P56465      149 -SVLETFALSFPKLKIIIEHLSDWRSIALIEKHd---------nLYATLTLHHISMTLDDllgg---------------- 202 Helicobacter pylori
Feature 1                                               #                                       
1J79_A      214 ----gvrpHLYCLPILKRNIHQQALRELVASGFQRVFLGTDSAPHARHRKe--------------------------sSC 263 Escherichia coli
ZP_00018287 201 ----llqpHLFCKPIAKRPTDRDALLAAALAGHPKLMFGSDSAPHPIDRKe---------------------------AA 249 Chloroflexus aur...
Q8K9L2      216 ----giqpHLYCLPLLKRKKHQIALRNVISSGSKNFFLGSDTAPHFHKNKi--------------------------nTF 265 Buchnera aphidic...
NP_281453   201 ----kmnpHLFCKPIAKRYEDKEALCELAFSGYEKVMFGSDSAPHPKDTKe---------------------------CC 249 Campylobacter je...
P31301      211 ------kpLNFCKPVAKYPDDRQALRDVIRQGHPRFFLGSDSAPHPLANKypsavthgapgtkasdsgsdhleatgvvSC 284 Ustilago maydis
NP_908104   206 ----alnpHLFCKPVLKLPRDREALQKAALGAHPKISFGSDSAPHPKEAKe--------------------------sAK 255 Wolinella succin...
Q9UTI0      206 ------dpYCFCKPVAKTERDRRALIEAATSKNPKFFFGSDSAPHPRSSKl--------------------------kTP 253 fission yeast
P20051      224 ------npVNFCKPVAKLPNDKKALVKAAVSGKPYFFFGSDSAPHPVQNKan-------------------------yEG 272 baker's yeast
AAM46078    244 caeavekpHNFCKPLAKTKRDRDALRQVIQDGDTHFFLGSDSAPHPRLAKe--------------------------sSP 297 Toxoplasma gondii
P56465      203 ----slnpHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDSAPHFISKKh--------------------------sAN 252 Helicobacter pylori
Feature 1                                                                                       
1J79_A      264 GCA-GCFNAPTALGSYATVFEEmnalqHFEAFcSVNGPQFYG-----LPVNDTFIELvr---------------eeQQVA 322 Escherichia coli
ZP_00018287 250 FCAaGVFSAPVLLPMLVELFERhnaldRLPDFvSGNARRIHG-----LNPPPRTVRLve---------------dpWQVP 309 Chloroflexus aur...
Q8K9L2      266 GCA-GIFNAPSSLLCYVSVFEEmnalqHFQSFcSENGPNFYN-----MPINKETITLvk---------------kpHKIL 324 Buchnera aphidic...
NP_281453   250 GCAaGVFSAPVILPVLAELFKQnsseeNLQKFlSDNTCKIYD-----LKFKEDKILTlee--------------keWQVP 310 Campylobacter je...
P31301      285 GCAaAVYTSSILVPLWPTLLEAfgaldQLANYvSINGRNFYGyn-ddQHAKHGSIKLrkvrsrscispaaatvpavYVHP 363 Ustilago maydis
NP_908104   256 GAA-GIFSAPLLLPLLAELFERhgkleNLQAFvSDNAHRIYG-----IAPLGKRVTLlq---------------eeSLIE 314 Wolinella succin...
Q9UTI0      254 PAA-GVFTQPFAASYLAEVFDKegrldALKDFaCIFGRKFYC-----IPLDFKESNIvlk-------------kesFRVP 314 fission yeast
P20051      273 VCA-GVYSQSFAIPYIAQVFEEqnaleNLKGFvSDFGISFYEvkdseVASSDKAILFkk----------------eQVIP 335 baker's yeast
AAM46078    298 PAA-GVFTQPLLLAYLVSIFAElgcisKLREFaDGHAAAFFGfeaatLEENLECAVIqp---------------tpQRVP 361 Toxoplasma gondii
P56465      253 IPA-GIFSAPILLPALCELFEKhnaleNLQAFiSDNAKTIYGle--nLPSKKARLSKk-----------------pFMIP 312 Helicobacter pylori
Feature 1                                 
1J79_A      323 e--SIAlt---ddTLVPflaGETVRW 343 Escherichia coli
ZP_00018287 310 m--RYG-------DVVPfaaGQTLRW 326 Chloroflexus aurantiacus
Q8K9L2      325 e--KINig---knIIVPflaGKRLDW 345 Buchnera aphidicola (Schizaphis graminum)
NP_281453   311 n--VYEdk---ynQVVPymaGEILKF 331 Campylobacter jejuni subsp. jejuni NCTC 11168
P31301      364 efrEVPdsdrskvQVVPfwaVSAGIV 389 Ustilago maydis
NP_908104   315 e--DYS-------GFIPpeaGKRVRW 331 Wolinella succinogenes
Q9UTI0      315 e--SVAn------DLVPfhpNEVLQW 332 fission yeast
P20051      336 q--VISdgk--diSIIPfkaGDKLSW 357 baker's yeast
AAM46078    362 s--IFKfpgqeneGVVPfmaSLELPY 385 Toxoplasma gondii
P56465      313 t--HTLcl---neKIAIlrgGETLSW 333 Helicobacter pylori

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap