Jie Zheng, Ph.D.
Research Scientist
Computational Biology Branch
Bethesda, MD 20894-0001
Tel: (301)-496-3713
Email: zhengj at

I am a Research Scientist working with Dr. Teresa M. Przytycka at NCBI on Computational Genomics and Systems Biology. I received my Ph.D. degree under the joint supervision of Prof. Stefano Lonardi and Prof. Tao Jiang in Department of Computer Science and Engineering at University of California, Riverside.

Research Interests

Computational Biology and Bioinformatics
Genomics, Systems Biology, Molecular Evolution, Population Genetics
Algorithm Design, Scientific Data Mining and Knowledge Discovery


Ph.D. Computer Science, University of California, Riverside (2006)
B.E. Computer Science, Zhejiang University, China (2000)


J. Zheng, PP Khil, RD Camerini-Otero, TM Przytycka. Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome. Genome Biology, 11:R103. 2010 (Highlighted on daily news of GenomeWeb)

J. Zheng*, D. Zhang, PF Przytycki, R. Zielinski, J. Capala, TM Przytycka* (co-corresponding author). SimBoolNet - A Cytoscape plugin for dynamic simulation of signaling networks. Bioinformatics, 26(1): 141-142, 2010

R. Zielinski, PF Przytycki, J. Zheng, D. Zhang, TM Przytycka, J. Capala. The crosstalk between EGF, IGF, and Insulin cell signaling pathways ĘC computational and experimental analysis. BMC Systems Biology, 3(88), 2009

Y. Huang*, J. Zheng*, Teresa M. Przytycka (*co-first author). Discovery of regulatory mechanisms from gene expression variation by eQTL analysis. Biological Data Mining, Chapman and Hall/CRC Press, 2009

J. Zheng, IB Rogozin, EV Koonin, TM Przytycka. Support for the Coelomata Clade of animals from a rigorous analysis of the pattern of intron conservation. Molecular Biology and Evolution, 24(11):2583-92,2007
Conference version: RECOMB Comparative Genomics, LNCS 4751, pp. 177-192, 2007

J. Zheng. Efficient Algorithms for Identification and Analysis of Repetitive Patterns in Biological Sequences. Ph.D. Dissertation in Computer Science, University of California, Riverside, 2006

J. Zheng, J. Svensson, K. Madishetty, T. Close, T. Jiang, S. Lonardi. OligoSpawn: a software tool for the design of overgo probes from large unigene databases. BMC Bioinformatics, 7:7, 2006

X. Chen, J. Zheng, Z. Fu, P. Nan, Y. Zhong, S. Lonardi and T. Jiang. Assignment of orthologous genes via genome rearrangement. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2(4), 302-315, 2005
Conference version (invited): Proc. of Asia-Pacific Bioinformatics Conference (APBC), pp. 363-378, 2005

J. Zheng, S. Lonardi. Discovery of repetitive patterns in DNA with accurate boundaries. Proc. of IEEE International Symposium on BioInformatics and BioEngineering (BIBE), pp. 105-112, 2005

A. Goldstein, P. Kolman, J. Zheng (authors alphabetized). Minimum common string partition problem: hardness and approximation. Electronic Journal of Combinatorics, 12(1), 2005
Conference version: Proc. of International Symposium on Algorithms and Computation (ISAAC), pp. 484-495, LNCS 3341, 2004

J. Zheng, T. Close, T. Jiang, S. Lonardi. Efficient Selection of Unique and Popular Oligos for Large EST Databases. Bioinformatics, 20(13), 2101-2112, 2004
Conference version: Proc. of Symposium on Combinatorial Pattern Matching (CPM), pp. 384-401, LNCS 2676, 2003


LDsplit -- Detect genomic loci associated with recombination hotspots

OligoSpawn -- Design oligonucleotide probes from large EST/unigene databases

SimBoolNet -- Dynamic simulation and visualization of signaling networks

Last updated: 09 Dec. 2010