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SRX9491558: GSM4905066: TOX3_2; Homo sapiens; RNA-Seq
1 ILLUMINA (Illumina HiSeq 2000) run: 23.3M spots, 7G bases, 2.1Gb downloads

Submitted by: NCBI (GEO)
Study: The Breast Cancer Susceptibility Gene TOX3 Promotes Estrogen Synthesis: An RNA-sequencing and Network Study
show Abstracthide Abstract
We aimed to explore the effect of the breast cancer susceptibility gene TOX3 on estrogen synthesis from the perspective of estrogen production, in an attempt to link abnormalities in hormone production with the development of breast cancer. After overexpression of TOX3, several crucial key genes and pathways that contribute to estrogen production were upregulated. Forced expression of TOX3 also promotes proliferation and inhibits apoptosis of granulosa cells. These findings discuss the possible impact of susceptibility genes and steroid hormones on breast cancer from the perspective of extra-mammary tissues such as those in the ovary, thus providing new insights for early prevention and treatment of breast cancer. Overall design: KGN mRNA profiles of TOX3 overexpression and control group
Sample: TOX3_2
SAMN16779383 • SRS7700379 • All experiments • All runs
Organism: Homo sapiens
Library:
Instrument: Illumina HiSeq 2000
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC
Selection: cDNA
Layout: PAIRED
Construction protocol: Total RNA was extracted by removing the culture medium and lysing the remaining cells using TRIzol™ Reagent (Takara Bio, Beijing, CHN) according to the manufacturer's instructions. RNA concentration and integrity number were determined using the Agilent 2100 Bioanalyzer (Agilent Technologies, Santa Clara, CA, USA). RNA libraries were prepared for sequencing using standard Illumina protocols
Experiment attributes:
GEO Accession: GSM4905066
Links:
Runs: 1 run, 23.3M spots, 7G bases, 2.1Gb
Run# of Spots# of BasesSizePublished
SRR1304159223,255,5477G2.1Gb2021-02-04

ID:
12406678

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