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SRX6809268: GSM4064138: ATAC-seq Control 1; Mus musculus; ATAC-seq
1 ILLUMINA (NextSeq 500) run: 34.4M spots, 4.7G bases, 2.1Gb downloads

Submitted by: NCBI (GEO)
Study: Long-term programming of CD8 T cell immunity by perinatal exposure to stress hormone [ATAC-seq]
show Abstracthide Abstract
Early life environmental exposure, particularly during perinatal period, can have a lifelong impact on organismal development and physiology. The biological rationale for this phenomenon is to promote physiological adaptation to the anticipated environment based on early life experience. However, perinatal exposure to adverse environments can also be associated with adult-onset disorders. Multiple environmental stressors induce glucocorticoids, which prompted us to investigate their role in developmental programming. Here, we report that perinatal glucocorticoid exposure had long-term consequences and resulted in diminished CD8 T cell response in adulthood and impaired control of tumor growth and bacterial infection. We found that perinatal glucocorticoid exposure resulted in persistent alteration of the hypothalamic-pituitaryadrenal (HPA) axis. Consequently, the level of the hormone in adults was significantly reduced, resulting in decreased CD8 T cell function. Our study thus demonstrates that perinatal stress can have long-term consequences on CD8 T cell immunity by altering HPA axis activity. Overall design: Three replicates of naive CD8 T cells from Control and DEX mice, respectively.
Sample: ATAC-seq Control 1
SAMN12703125 • SRS5353457 • All experiments • All runs
Organism: Mus musculus
Library:
Instrument: NextSeq 500
Strategy: ATAC-seq
Source: GENOMIC
Selection: other
Layout: PAIRED
Construction protocol: Genomic DNAs were extracted by DNA Clean & Concentrator (Zymo). ATAC-seq libraries were constructed with 50K cells from each condition following Omni-ATAC protocol (Illumina FC-121-1031(Corces et al., 2017))
Experiment attributes:
GEO Accession: GSM4064138
Links:
Runs: 1 run, 34.4M spots, 4.7G bases, 2.1Gb
Run# of Spots# of BasesSizePublished
SRR1007588034,411,9914.7G2.1Gb2020-01-02

ID:
8967868

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