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SRX14313340: GSM5922041: C114_C7_L1_38w_RepI; Mus musculus; RNA-Seq
1 ILLUMINA (NextSeq 500) run: 233,928 spots, 17.8M bases, 8.1Mb downloads

External Id: GSM5922041_r1
Submitted by: Functional Genomics, Epigenomics - S. Oliviero, Life Sciences and Systems Biology, University of Turin
Study: Wound memory of epidermal stem cells [scRNAseq L1-aged]
show Abstracthide Abstract
Wound priming in epidermal Lrig1 stem cell progeny leads to a more efficient response to future injuries. To understand if primed progenitors maintain during aging the transcriptional program acquired during wound healing in young age, we performed single cell RNA-Seq of Lrig1 stem cell progeny 40 weeks after injury. Overall design: Single cell RNA-seq transcriptome profiling of epidermal Lrig1 stem cell progenies. After genetical labelling through tamoxifen application, tomato positive epidermal cells were sorted from repaired and age control skin.
Sample: C114_C7_L1_38w_RepI
SAMN26311484 • SRS12129486 • All experiments • All runs
Organism: Mus musculus
Library:
Name: GSM5922041
Instrument: NextSeq 500
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC
Selection: cDNA
Layout: SINGLE
Construction protocol: Flow citometry was used to sort tomato positive epidermal cells Full length single cell RNA-seq was performed using a modified version of the Smart-seq2 protocol. Briefly, individual cells are sorted into 96 well plates containing lysis buffer in presence of RNase inhibitor, dNTPs and OligodT. Reverse transcription of the polyadenylated RNA will be performed with SuperScriptII and Template Switching Oligos. The resulting cDNA will be amplified with 25 cycles of PCR and libraries will be prepared for sequencing with standard NexteraXT Illumina protocol. Libraries were sequenced on Illumina NextSeq 500 System (single-end 75bp reads).
Runs: 1 run, 233,928 spots, 17.8M bases, 8.1Mb
Run# of Spots# of BasesSizePublished
SRR18166099233,92817.8M8.1Mb2023-02-02

ID:
20286282

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