show Abstracthide AbstractBisulfite padlock probe technique was used to examine DNA modifications at the lactase gene region for human and mouse tissues Overall design: DNA modifications were investigated in human sperm, blood, jejunal enterocytes and jejunum lacking enterocytes, as well as mouse jejunal enterocytes and jejunum lacking enterocytes. For WGA samples, a genome devoid of DNA modifications was used to verify the efficiency of the bisulfite conversion reactions (the tissue sources were human or mouse intestine).